Abstract:
PURPOSES:Hepatic lipid overloading induces lipotoxicity which can cause hepatocyte damage, fibrosis, and eventually progress to cirrhosis, which is associated with nonalcoholic fatty liver disease. Adiponectin receptors play important roles in regulating lipid metabolism. In this study, we used a lentivirus system to overexpress the adiponectin receptor 1 (AdipoR1) in HepG2 cells to define the role of adiponectin and its receptor 1 in the development of fatty liver syndrome. METHODS AND RESULTS:Exposure of human hepatocytes, HepG2 cells, to palmitate (0.2 or 0.4 mM) for 16 h resulted in elevated apoptosis, whereas AdipoR1 decreased the palmitate-induced apoptosis. Transgene AdipoR1 increased the expression of FATP2, acyl-coA oxidase, and carnitine palmitoyltransferase I in palmitate-treated HepG2 cells. The transcript level of acetyl-CoA carboxylase and fatty acid synthase was upregulated by palmitate treatment, while AdipoR1 reversed the effect induced by palmitate. AdipoR1 increased the gene expression of cytochrome C oxidase, peroxisome proliferator-activated receptor α, and decreased the gene expression of PGC1α and AMPKα in HepG2 cells under palmitate treatment. Palmitate suppressed ATP production, while transgene AdipoR1 reversed the decreased ATP production by palmitate. Transgene AdipoR1 enhanced AKT phosphorylation in HepG2 cells both with and without palmitate treatment. When PI3 kinase inhibitor was applied, the protective effect of AdipoR1 was absent, such that palmitate again decreased ATP production while also reducing cell viability. CONCLUSION:AdipoR1 enhances fatty acid metabolism and cell viability in palmitate-treated HepG2 cells partially by activating AKT signaling. Therefore, AdipoR1 has therapeutic potential in the treatment of nonalcoholic fatty liver disease.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Chou IP,Lin YY,Ding ST,Chen CYdoi
10.1007/s00394-013-0594-7subject
Has Abstractpub_date
2014-04-01 00:00:00pages
907-17issue
3eissn
1436-6207issn
1436-6215journal_volume
53pub_type
杂志文章abstract:PURPOSE:Results from epidemiologic studies on coffee consumption and the risk of cutaneous melanoma are inconsistent. We conducted a meta-analysis to assess the associations between the consumption of total coffee, caffeinated coffee and decaffeinated coffee and the risk of cutaneous melanoma, respectively. METHODS:A ...
journal_title:European journal of nutrition
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00394-015-1139-z
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Inulin-type fructans or chains with mainly beta[2-1] linked fructose molecules escape the ingestion procedure in the small intestine and are fermented by the microflora, and are known to increase colonic absorption of minerals in animals. The fermentation rate in the large bowel into short-chain fatty acids ...
journal_title:European journal of nutrition
pub_type: 杂志文章
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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abstract:: ...
journal_title:European journal of nutrition
pub_type: 信件
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章
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journal_title:European journal of nutrition
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pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
pub_type: 杂志文章
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Rooibos tea (Aspalathus linearis) is commonly used for hyperactive gastrointestinal, respiratory and cardiovascular disorders. AIM OF STUDY:The aqueous extract of Rooibos tea (RT) was studied for the possible bronchodilator, antispasmodic and blood pressure lowering activities in an attempt to rationalize s...
journal_title:European journal of nutrition
pub_type: 杂志文章
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