Abstract:
PURPOSE:In this study, we sought to find the effects and mechanisms of probiotic Lactobacillus casei Zhang (L. casei Zhang) on the pro-inflammatory cytokine production and hepatic inflammatory response in a rat model of acute liver failure induced by lipopolysaccharide (LPS) and d-galactosamine (GalN). METHODS:Male Wistar rats were orally administrated with or without L. casei Zhang for 30 days prior to challenge with LPS and GalN. Dexamethasone administrated group serving as a positive anti-inflammation control. Serum, intestinal and liver samples were collected 8 h after LPS/GalN challenge for histological, molecular and biochemical analysis. RESULTS:LPS/GalN challenge alone resulted in significantly increased production of endotoxin, tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β) and nitric oxide as compared to the normal control rats. Pretreatment with L. casei Zhang not only reduced these changes, but also attenuated hepatic inflammation as shown by improved histological assessment, decreased myeloperoxidase activity and reduced expression of IL-1β and inducible nitric oxide synthase in the liver. L. casei Zhang supplementation significantly inhibited LPS/GalN-triggered phosphorylation of ERK, JNK and p-38 MAPK, but increased the expression of TLR2, TLR9 and PPAR-γ. Moreover, L. casei Zhang treatment prevented intestinal injury and modulated the intestinal ecology by increasing the fecal Lactobacillus and Bifidobacterium levels. CONCLUSIONS:Probiotic L. casei Zhang reduces LPS/GalN-induced pro-inflammatory cytokine and hepatic inflammation through modulating the TLR-MAPK-PPAR-γ signaling pathways and intestinal microbiota.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Wang Y,Xie J,Li Y,Dong S,Liu H,Chen J,Wang Y,Zhao S,Zhang Y,Zhang Hdoi
10.1007/s00394-015-0904-3subject
Has Abstractpub_date
2016-03-01 00:00:00pages
821-831issue
2eissn
1436-6207issn
1436-6215pii
10.1007/s00394-015-0904-3journal_volume
55pub_type
杂志文章abstract:PURPOSE:It is believed that breakfast is an important meal due to its effect on appetite control and cognitive performance, yet little evidence exists to support this hypothesis. METHODS:Using a crossover design, 33 healthy undergraduates (aged 22 ± 2 years with a BMI of 23.5 ± 1.7 kg/m2) were randomized one of four b...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2020-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:European journal of nutrition
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pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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更新日期:2020-08-17 00:00:00
abstract:PURPOSE:Iodine deficiency affects 30% of populations worldwide. The amount of thyroglobulin (Tg) in blood increases in iodine deficiency and also in iodine excess. Tg is considered as a sensitive index of iodine status in groups of children and adults, but its usefulness for individuals is unknown. The aim of this stud...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2020-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-04-01 00:00:00
abstract:PURPOSE:This study aimed to assess the effects of folic acid (FA) combined with a docosahexaenoic acid (DHA) intervention on the cognitive function and inflammatory cytokines in elderly subjects with mild cognitive impairment (MCI). METHODS:This randomized, double-blind, placebo-controlled trial recruited 240 individu...
journal_title:European journal of nutrition
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更新日期:2020-08-28 00:00:00
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00