Abstract：
PURPOSE:To test the effect of three diets in their ability to sustain weight loss and improve type 2 diabetes (T2D) and cardiovascular disease (CVD) risk markers after 18-month intervention. METHODS:Following a ≥8 % weight loss, 131 healthy, overweight/obese (BMI ± SD 31.5 ± 2.6 kg/m2) men (n = 55) and women (n = 76) aged 28.2 ± 4.8 years were randomized to either 1. Moderate fat (40 E%) with 20 E% MUFA and low in glycemic index (GI) (MUFA, n = 54), 2. Low fat (25 E%) and medium in GI (LF, n = 51) or 3. Control (35 E% fat) and high in GI (CTR, n = 26) all with similar protein content, and all provided ad libitum. First 6-month intervention with 100 % food provision (previously reported) following 12 months of moderately intensive intervention with 20 % food provision now reported. RESULTS:Attrition rate was higher in MUFA (63 %) than in LF (37 %, P = 0.019) and CTR (42 %, P = 0.09) group. Weight regain in completers was not different between groups (mean ± SEM), MUFA 7.1 ± 2.1 % versus LF 5.6 ± 1.3 % versus CTR 7.2 ± 1.5 %, nor was body fat regain, MUFA 4.8 ± 1.0 % versus LF 4.7 ± 0.8 % versus CTR 5.7 ± 0.6 %. The MUFA group reduced LDL/HDL ratio by -0.47 ± 0.09 compared with -0.23 ± 0.11 in LF (P < 0.05) and 0.06 ± 0.14 (P < 0.005) in CTR groups. CONCLUSIONS:Weight regain or body composition did not differ between diets over 18 months. No effects on risk markers for T2D or CVD were found, with the exception of an improvement in the LDL/HDL ratio by the MUFA diet compared to the CTR diet. The LF diet was generally more satisfactory and the MUFA diet seemed more difficult to follow.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Due A,Larsen TM,Mu H,Hermansen K,Stender S,Toubro S,Allison DB,Astrup Adoi
10.1007/s00394-015-1116-6subject
Has Abstractpub_date
2017-03-01 00:00:00pages
727-738issue
2eissn
1436-6207issn
1436-6215pii
10.1007/s00394-015-1116-6journal_volume
56pub_type
杂志文章,随机对照试验abstract：PURPOSE:Reports on the protective effect of a Mediterranean diet on mortality usually refer to populations from Mediterranean countries, leaving uncertain whether really diet is the fundamental cause. Our aim was to examine the effect of a Mediterranean diet on mortality in Switzerland, a country combining cultural inf...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0695-y
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:Walnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer. METHODS:COLO205 cells were pretreated with WPE and then stimulated with tu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1704-3
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:Previous studies have shown that high-dose supplementation with n-3 polyunsaturated fatty acids (PUFAs) may benefit patients with nonalcoholic fatty liver disease (NAFLD), but the association of n-3 PUFAs with NAFLD among individuals with normal diets is only speculative. We investigated the cross-sectional and...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-01953-2
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:Anemia and vitamin D deficiency are both frequent in adult patients. Whether low vitamin D metabolite levels are an independent risk factor for different subtypes of anemia remains to be studied in detail. METHODS:In 3299 patients referred for coronary angiography, we investigated the association of 25-hydroxy...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1149-x
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:The associations between specific carotenoid intake and colorectal cancer risk remain inconsistent. The aim of this study was to examine the association between specific dietary carotenoid intake with colorectal cancer risk in Chinese adults. METHOD:From July 2010 to October 2013, 845 eligible colorectal cance...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0743-7
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Rebalancing the contribution of animal- and plant-based foods is needed to achieve sustainable diet. However, little is known concerning individual characteristics that may influence intake of plant-based foods and their changes over time. We aimed to assess changes in the contribution of plant-based foods to d...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1752-8
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:At the present time the recommended daily intake or allowance (RDA) and the safe upper level (UL) of intake of micronutrients are given as single values. The recommended daily intake is considered to cover the requirements of 97.5% of the population while the safe upper level is a value for the whole populat...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-007-0691-6
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:Constitutive activation of the Wnt signaling pathway and its downstream effectors plays a key role in neoplastic transformation. The objective of this study was to investigate the effect of ellagic acid, a plant-derived polyphenol on Wnt/β-catenin signaling and its downstream circuits- NF-κB and mitochondrial a...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0288-y
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association bet...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02331-z
更新日期：2020-07-18 00:00:00
abstract：INTRODUCTION:Bioavailability is a critical feature in the assessment of the role of micronutrients in human health. Poorly bioavailable micronutrients like carotenoids may reach significant concentrations in the gastrointestinal tract where they may exert biological actions. PURPOSE:We evaluated a simple collection pr...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-015-0939-5
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:To investigate whether early introduction of complementary foods (CF) is associated with an increased risk of overweight during childhood, and whether this association differs between formula-fed and breastfed infants. METHODS:We included 2611 participants that were born at term from a Dutch population-based b...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1639-8
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher conce...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0698-8
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Dietary polyphenols have been reported to have a variety of biological actions, including anticarcinogenic and antioxidant activities. AIM OF THE STUDY:In the present study we investigated the protective effect of dietary polyphenols against N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR) and ben...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-008-0751-6
更新日期：2008-12-01 00:00:00
abstract：PURPOSE:The objective of the present study was to test the hypothesis that N-acetylcysteine (NAC) may play beneficial roles against intrauterine growth retardation (IUGR)-induced hepatic damage in suckling piglets. METHODS:Fourteen IUGR and seven normal birth weight (NBW) neonatal male piglets were selected. Piglets w...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-016-1322-x
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The transcription factor NF-kappaB is suggested to play a pivotal role in atherogenesis by regulating the expression of proinflammatory gene products such as adhesion molecules. Garlic is consumed as food or dietary supplement in order to benefit from its antiatherogenic effect. AIM OF THE STUDY:This study ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-004-0437-7
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:Considerable variation in 25-hydroxyvitamin D (25(OH)D) in populations worldwide that seems to be independent of latitude has been reported. Therefore, we aimed to assess vitamin D status of a mid-aged German general population and to identify its dietary, lifestyle, anthropometric, and genetic determinants. M...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0577-8
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:The fat mass and obesity-associated gene (FTO) is related to obesity and coronary heart disease (CHD). We studied interaction between macronutrient intake and FTO in association with CHD risk or body mass index (BMI). METHODS:The pooled population-based case-control studies, SHEEP and INTERGENE, included 1,381...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0842-0
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:To investigate the longitudinal association between the macronutrient composition of the diet and frailty. METHODS:Data were obtained from 5205 Dutch middle-aged and older adults participating in the Rotterdam Study. Frailty was measured using a frailty index based on the accumulation of 38 health-related defi...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02131-0
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Although research suggests that antioxidant supplementation can protect against exercise-induced muscle damage and oxidative stress, also delayed post-exercise muscle recovery and hindered adaptation to training were reported in the supplemented athletes. PURPOSE:The purpose of the study was to evaluate the...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-014-0757-1
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:The aims of this study were to evaluate the antihypertensive effectiveness of different doses of grape seed polyphenols in cafeteria diet-fed hypertensive rats (CHRs) and to establish the mechanism involved in the blood pressure (BP) lowering effect of these compounds in this experimental model of metabolic syn...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0895-0
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:Organic acids from plant food have been shown to play an important role in the prevention of chronic diseases (osteoporosis, obesity), inherent to western diets, but little is known about their bioavailability in the small intestine, information that needs to be determined in order to quantify likely effec...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-010-0112-0
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:To compare the glycaemic response of whole grain oat kernels and pearled oats cooked under normal pressure or higher pressure and examine whether replacing half of the rice in a given meal with either of the two oat grains could make a difference in acute glycaemic responses. METHODS:In a randomised crossover ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02083-5
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula. METHODS:A nested case-control study was ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1668-3
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:Heme iron may contribute to the development of atherosclerosis by catalyzing production of hydroxyl-free radicals and promoting low-density lipoprotein oxidation. However, epidemiologic findings regarding the association between heme iron intake and risk of coronary heart disease (CHD) are inconsistent. We aime...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析
doi：10.1007/s00394-013-0535-5
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:The aim of the present study was to assess whether the effects of acute consumption of stout or pilsner beer on the liver differ from those of plain ethanol in a mouse model. METHODS:Seven-week-old female C57BL/6J mice received either ethanol, stout or pilsner beer (ethanol content: 6 g/kg body weight) or isoc...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0730-z
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:This study assessed the association between animal source foods (ASF) consumption and hypertension, a recognised risk factor for cardiovascular disease. Adverse effects of red and processed meat (RPM) consumption and beneficial effects of the consumption of dairy products and other ASF have been discovered sepa...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02423-w
更新日期：2020-11-05 00:00:00
abstract：PURPOSES:Hepatic lipid overloading induces lipotoxicity which can cause hepatocyte damage, fibrosis, and eventually progress to cirrhosis, which is associated with nonalcoholic fatty liver disease. Adiponectin receptors play important roles in regulating lipid metabolism. In this study, we used a lentivirus system to o...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0594-7
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:Impaired insulin sensitivity (SI) and β-cell function are the two main causes of type 2 diabetes (T2D) and are related to low-grade inflammation status. Trivalent chromium has shown to improve SI in our previous study. This might be due to the ability of decreasing interleukin-6 (IL-6) and tumor necrosis fact...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-013-0508-8
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:Non-alcoholic fatty liver disease (NAFLD), known to be related to insulin resistance, has been the focus of intensive research efforts due to its increasing prevalence and clinical significance. Rapid eating behavior is another emerging health issue associated with insulin resistance. We aimed to clarify the co...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0851-z
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Our aim was to investigate the effect of the dietary fat on the two main adipose tissue functions, endocrine and lipid store, by analyzing the adipose tissue gene expression from metabolic syndrome patients. METHODS:A randomized...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-013-0570-2
更新日期：2014-01-01 00:00:00
