Abstract：
OBJECTIVE:Impaired insulin sensitivity (SI) and β-cell function are the two main causes of type 2 diabetes (T2D) and are related to low-grade inflammation status. Trivalent chromium has shown to improve SI in our previous study. This might be due to the ability of decreasing interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) shown in animal studies. In the current study, we measured SI, β-cell function, and plasma levels of IL-6 and TNF-α after treatment of chromium chloride (GaCr) in T2D. RESEARCH DESIGN AND METHODS:Sixty-six patients were randomly assigned to the 20 g of GaCr milk powder studying group or the milk powder placebo group. Oral glucose tolerance test was performed before and after the treatment. The SI and the β-cell function were measured as well. RESULTS:The SI was significantly improved. At the same time, the static insulin responsivity index (Φs) was significantly higher after the treatment (p = 0.003). On the other hand, the dynamic insulin responsivity index (Φd) remained unchanged. Interestingly, a significant decrease in the IL-6 level after the treatment (p = 0.015) was noted. Although there was a trend of decreasing in TNF-α, it was not statistically significant. Finally, there was no significant correlation between the δ-IL-6, SI, and Φd after GaCr treatment. CONCLUSIONS:In conclusion, other than the improvement of SI, GaCr could also improve the second phase of insulin responsivity (Φs) and IL-6. However, δ-IL-6 was correlated with neither δ-SI nor δ-Φs which indicated that the improvement of SI and Φs might involve mechanisms other than lower inflammatory effect.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Chen YL,Lin JD,Hsia TL,Mao FC,Hsu CH,Pei Ddoi
10.1007/s00394-013-0508-8subject
Has Abstractpub_date
2014-02-01 00:00:00pages
127-33issue
1eissn
1436-6207issn
1436-6215journal_volume
53pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Flavonoids have physiological activity and a variety of pharmacological properties, including anticancer activity in vitro, but structure-anticancer activity relationships are unclear. AIM:The objectives of this work were to investigate the activity of dietary flavonol congeners against cell lines derived f...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0204-5
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:We examined whether high doses of folic acid and iron supplementation in early-to-mid pregnancy affect the risk of preterm birth, low birth weight, and small for gestational age neonates, in the mother-child cohort in Crete, Greece (Rhea study). METHODS:We included 1,279 women with singleton pregnancies with c...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-012-0339-z
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Although several observational studies have consistently reported an inverse association between moderate alcohol consumption and risk of coronary heart disease (CHD), it is yet not well established if this association also exists among people with type 2 diabetes. The aim of this study is to evaluate the as...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-009-0065-3
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Diet has an important role in host-microbiome interplay, which may result in intestinal permeability changes and physiopathological effects at a systemic level. Despite the importance of maternal microbiota as the main contributor to the initial microbial seeding, little is known about the effects of materna...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02337-7
更新日期：2020-07-29 00:00:00
abstract：PURPOSE:Sesamin, a polyphenolic compound found in sesame seeds, has been reported to exert a variety of beneficial health effects. We have previously reported that sesamin increases the lifespan of Caenorhabditis elegans. In this study, we investigated the molecular mechanisms underlying the longevity effect of sesamin...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1396-0
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:Advanced glycation endproducts (AGEs) are produced endogenously and also enter the body during the consumption of AGEs present in heat-processed food. It is unknown whether AGEs of dietary origin accumulate within the body of healthy individuals. AGEs can deposit within skin tissue long-term by crosslinking ext...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1495-y
更新日期：2018-09-01 00:00:00
abstract：:Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, ...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-012-0331-7
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:Critically low skeletal muscle mass and strength, observed in 20% of people with chronic heart failure (CHF), reduces functional capacity, quality of life (QoL) and survival. Protein and essential amino acid (EAA) supplementation could be a viable treatment strategy to prevent declines in muscle strength and pe...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-019-02108-z
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:While a relationship between alcohol and cardiovascular risk factors is well established, data suggest that the type of alcoholic beverage could modulate this relationship. AIM OF THE STUDY:To determine whether drinking patterns modulate the relationship between alcohol and cardiovascular risk factors. MET...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-005-0567-6
更新日期：2006-03-01 00:00:00
abstract：BACKGOUND:Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE:To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postpr...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-018-1612-6
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:Nicotinic acid is one of the older drugs used to treat hyperlipidemia, the greatest risk factor of coronary heart disease. Nicotinic acid is also a precursor of the coenzyme nicotinamide adenine dinucleotide (NAD). In mammals, α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) plays a key role in NA...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0547-1
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. AIM OF THE STUDY:To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel t...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-003-0421-7
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Although research suggests that antioxidant supplementation can protect against exercise-induced muscle damage and oxidative stress, also delayed post-exercise muscle recovery and hindered adaptation to training were reported in the supplemented athletes. PURPOSE:The purpose of the study was to evaluate the...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-014-0757-1
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:Choline-containing dietary phospholipids, including phosphatidylcholine (PC), may function as anti-inflammatory substances, but the mechanism remains largely unknown. We investigated the effects of L-alpha-glycerylphosphorylcholine (GPC), a deacylated PC derivative, in a rodent model of small intestinal ischaem...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0691-2
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine whether grape polyphenols have a "second-meal effect", modulating glucose and lipid elevations in the postprandial period after two successive meals in subjects with obesity. METHODS:A randomized, double-blind, placebo-controlled, acute clinical trial was conducted. Twent...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02451-6
更新日期：2021-01-02 00:00:00
abstract：PURPOSE:Telomere length is a biomarker for aging. It is known that oxidative stress can accelerate telomere shortening, whereas antioxidants can delay their shortening. Carotenoids as antioxidants are favorably associated with health- and aging-related diseases caused by oxidative stress, but their association with tel...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-016-1152-x
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:The goals of this study were to monitor the effect of drinking of herbal tea from Sideritis clandestina subsp. clandestina for 6 weeks on behavioral and oxidant/antioxidant parameters of adult male mice and also to evaluate its phytochemical composition. METHODS:The phytochemical profile of the Sideritis tea w...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0292-2
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:To describe the patterns of ultra-processed foods (UPFs) consumption in the Netherlands; to test if exposure to the food environment is associated with UPFs consumption; and if this association differed across educational levels and neighbourhood urbanisation. METHODS:Cross-sectional study using 2015-data of 8...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02436-5
更新日期：2020-11-24 00:00:00
abstract：BACKGROUND:Addition of capsaicin to the diet has been shown to increase satiety and thermogenesis. The effects of capsaicin on ghrelin, peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), in relation to changes in hunger and satiety are unknown. AIM:To test the acute effects of a lunch containing capsaicin on gut de...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0006-1
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Inulin has been suggested to have beneficial effects on lipids, especially on triglyceridemia. Few data are available about the effects of inulin on Lipoprotein(a), a low-density lipoprotein-like particle considered as an independent risk factor for atherosclerosis. Adding inulin to pasta could be a preventi...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-008-0748-1
更新日期：2008-12-01 00:00:00
abstract：PURPOSE:It was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine. METHODS:Male Wistar rats were randomly assigned to four groups o...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0775-z
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:The study of vitamin D status at population level gained relevance since vitamin D deficiency was recently suggested to trigger chronic disease. AIM OF THE STUDY:We aimed to describe vitamin D status, its association with bone and mineral metabolism and risk factors for deficiency in adults over 40 years in...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-008-0756-1
更新日期：2009-02-01 00:00:00
abstract：:In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected. ...
journal_title：European journal of nutrition
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00394-018-1800-4
更新日期：2018-10-01 00:00:00
abstract：:Previous studies have demonstrated the anti-inflammatory effect of fructooligosaccharides (FOS) on intestinal inflammation. The aim of the present study was to elucidate whether the colonic fermentation of these carbohydrates is a pre-requisite for this anti-inflammatory activity.With this aim short chain-FOS (SC-FOS)...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-006-0610-2
更新日期：2006-10-01 00:00:00
abstract：:Low intracellular magnesium (Mg) contents may be observed in case of severe Mg insufficient intake or because of genetic regulation. This work was conducted to investigate the influence of intracellular Mg content on erythrocyte Mg(2+) influx and efflux in mice with low nutritionally and genetically (MGL and MGH mice)...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-005-0579-2
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:Our aim was to characterize the effect of an unfamiliar high-fat diet (HFD) on circadian feeding behaviour, plasma parameters, body weight (BW), and gene expression in the prefrontal cortex (PFC) of adolescent male mice. To this end, mice were allowed to consume a HFD during 48 h, but one group was allowed a fr...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-016-1225-x
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:Chronic sugar-sweetened beverage (SSB) consumption is associated with obesity and type 2 diabetes mellitus (T2DM). Hyperglycaemia contributes to metabolic alterations observed in T2DM, such as reduced oxidative capacity and elevated glycolytic and lipogenic enzyme expressions in skeletal muscle tissue. We aimed...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章
doi：10.1007/s00394-012-0401-x
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:It is unclear if midlife consumption of dairy and soy food intake, and their components of calcium and isoflavones (in soy), is related to cognitive impairment in elderly. METHODS:We used baseline data on lifestyle and habitual diet of 16,948 participants collected during their recruitment into the Singapore C...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02010-8
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effe...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1385-3
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...
journal_title：European journal of nutrition
pub_type： 杂志文章,多中心研究
doi：10.1007/s00394-012-0473-7
更新日期：2013-10-01 00:00:00
