Abstract:
BACKGROUND:Although several observational studies have consistently reported an inverse association between moderate alcohol consumption and risk of coronary heart disease (CHD), it is yet not well established if this association also exists among people with type 2 diabetes. The aim of this study is to evaluate the association between the frequency and quantity of alcohol intake and the risk of developing CHD among postmenopausal women with diabetes.
METHODS:We conducted a prospective cohort study, which included 3,198 women with self-reported diabetes and without any history of cardiovascular disease at baseline, in the Women's Health Initiative Observational Study. Alcohol intake was assessed by a semiquantitative food frequency questionnaire. The primary outcome of this study was CHD, which was validated by medical record review. Cox proportional hazards regression was used to estimate the hazard ratio (HR) for the association of alcohol intake and risk of incident CHD while adjusting for several potential confounders.
RESULTS:During the 22,546 person-years of follow-up, there were 336 incident cases of CHD. Both frequency and quantity of alcohol intake were inversely associated with the risk of developing CHD. Compared to nondrinkers, the multivariable HRs across categories of frequency of alcohol consumption (
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Rajpathak SN,Freiberg MS,Wang C,Wylie-Rosett J,Wildman RP,Rohan TE,Robinson JG,Liu S,Wassertheil-Smoller Sdoi
10.1007/s00394-009-0065-3subject
Has Abstractpub_date
2010-06-01 00:00:00pages
211-8issue
4eissn
1436-6207issn
1436-6215journal_volume
49pub_type
杂志文章abstract:BACKGROUND:The best nutritional option for newborn infants is mother's milk. However, some newborn babies may not be exclusively breastfed during the first months of life, potentially leading to reduced overall health status and the early onset of allergic diseases in some infants. Considerable research has been devote...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
doi:10.1007/s003940070024
更新日期:2000-06-01 00:00:00
abstract:PURPOSE:Glucosinolates/isothiocyanates are an established class of naturally occurring chemopreventive agents, a principal mechanism of action being to limit the generation of genotoxic metabolites of chemical carcinogens, as a result of modulation of cytochrome P450 and phase II detoxification enzymes. The objective o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0397-2
更新日期:2013-04-01 00:00:00
abstract::Carotenoids are important micronutrients in the human diet and are present in human serum at micromolar concentrations. In addition to their antioxidant potential, carotenoids obtain physiologically relevant properties such as influencing cellular signal pathways, gene expression or induction of detoxifying enzymes. I...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0475-1
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:Our aim was to characterize the effect of an unfamiliar high-fat diet (HFD) on circadian feeding behaviour, plasma parameters, body weight (BW), and gene expression in the prefrontal cortex (PFC) of adolescent male mice. To this end, mice were allowed to consume a HFD during 48 h, but one group was allowed a fr...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1225-x
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1687-0
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Faster eating is positively associated with body mass index in apparently healthy Japanese populations. In the present study, we examined the associations between self-reported rate of eating and visceral and subcutaneous fat areas in apparently healthy middle-aged Japanese men. METHODS:We conducted a cross-se...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0619-2
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:To describe total fluid intake (TFI) and types of fluid consumed in urban China by age, gender, regions and city socioeconomic status relative to the adequate intakes (AI) set by the Chinese Nutrition Society. METHODS:In 2016, participants aged 4-9, 10-17 and 18-55 years were recruited via a door-to-door appro...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1755-5
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02395-x
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:Although several researches have demonstrated that rooibos extract has hypoglycemic effect, the role of aspalathin, a main polyphenol in the extract, remains unclear. Our aims were to find specific mechanisms for anti-diabetic action of aspalathin employing a rat skeletal muscle-derived cell line (L6 myocytes) ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0466-6
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:Blueberries are a rich source of anthocyanins (ACNs) and phenolic acids (PA), which are hypothesized to protect against development of atherosclerosis. The present study examined the effect of an ACN- and PA-rich fractions, obtained from a wild blueberry powder, on the capacity to counteract lipid accumulation ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0835-z
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat's pups; on yield, cytokines and milk composition was studied. METHODS:Lactobacillus plantarum L...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1628-y
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:While the prevalence of children on vegetarian diets is assumed to be on the rise in industrialized countries, there are hardly any representative data available. In general, vegetarian diets are presumed to be healthy; nevertheless, there are concerns as to whether the dietary specifications required during in...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-017-1416-0
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:Previous studies have shown that high-dose supplementation with n-3 polyunsaturated fatty acids (PUFAs) may benefit patients with nonalcoholic fatty liver disease (NAFLD), but the association of n-3 PUFAs with NAFLD among individuals with normal diets is only speculative. We investigated the cross-sectional and...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-01953-2
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Uroguanylin (UGN) is a 16 amino acid peptide produced mainly by intestinal epithelial cells. Nutrients intake increases circulating levels of prouroguanylin that is processed and converted to UGN to activate the guanylyl cyclase 2C receptor (GUCY2C). Given that the UGN-GUCY2C system has been proposed as a novel...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0869-2
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Anemia and vitamin D deficiency are both frequent in adult patients. Whether low vitamin D metabolite levels are an independent risk factor for different subtypes of anemia remains to be studied in detail. METHODS:In 3299 patients referred for coronary angiography, we investigated the association of 25-hydroxy...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1149-x
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association bet...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02331-z
更新日期:2020-07-18 00:00:00
abstract:PURPOSE:Epidemiological studies directly examining the association between habitual yoghurt consumption and mental health remain scarce. The aim of this study is to investigate the association of yoghurt consumption with depressive symptoms in adults. METHODS:This is a cross-sectional study of 19,596 Chinese adults (m...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1532-x
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To investigate whether age influences colonic polyphenol metabolism. METHODS:Healthy participants, younger (n = 8; 23-43 years) and older (n = 13; 51-76 years), followed a 3-day low-polyphenol diet (LPD) and a 3-day high-polyphenol diet (HPD). Urinary phenolic acids (PA), short chain fatty acids (SCFA), pH and...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1625-1
更新日期:2019-04-01 00:00:00
abstract::The objective of this study was to assess the effect of conjugated linoleic acid isomers (CLAs) on the expression and activity of phospholipases A(2) (PLA(2)) in human macrophages. Macrophages were incubated with 30 microM cis-9, trans-11 and trans-10, cis-12 CLAs for 48 h. After incubation, the total activity of phos...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0626-7
更新日期:2007-02-01 00:00:00
abstract:PURPOSE:Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily increase insulin secretio...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1644-y
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Excessive consumption of soft drinks is associated with nonalcoholic fatty liver disease (NAFLD). However, the association between soft drinks consumption and NAFLD is unclear in non-Caucasian adults with relatively low soft drinks consumption. The aim of this study was to assess the association between soft dr...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1485-0
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:The combined hyperglycemia lowering and antioxidant actions of α-lipoic acid (LA) contribute to its usefulness in preventing renal injury and other diabetic complications. The precise mechanisms by which LA alters diabetic oxidative renal injury are not known. We hypothesized that LA through its hypoglycemic ef...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0452-z
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Exposure to breastfeeding improves the survival, health, and development of children; therefore, breast milk is recommended as the exclusive nutrient source for feeding term infants during the first 6 months. This cross-sectional study aimed to determine the possible association between exposure to exclusive br...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1337-3
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Tryptophan is an essential amino acid, precursor of serotonin. Serotonin (5HT) regulates the secretion of pituitary growth hormone (GH), which in turn stimulates the liver to produce insulin-like growth factor-I (IGF-I) that is necessary for development and growth. The aim of our study was to investigate the ef...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0528-4
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:Accumulating evidence suggests that inhibitors of aldose reductase (AR) may prevent hyperglycemia-induced long-term complications in diabetes mellitus. In the present study, we evaluated the AR inhibitory potential of ethanolic (EtOH) extracts from 22 seaweed species. METHODS:AR inhibitory activities of the se...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0521-y
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:Polydextrose is a low-calorie highly branched-chain glucose polymer that is poorly digested in the upper gastrointestinal tract and therefore demonstrates fibre-like properties. Fibre has been shown to increase satiety and possibly reduce food intake. Therefore, the objective of the current study was to examine...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-012-0395-4
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Diet has an important role in host-microbiome interplay, which may result in intestinal permeability changes and physiopathological effects at a systemic level. Despite the importance of maternal microbiota as the main contributor to the initial microbial seeding, little is known about the effects of materna...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02337-7
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Dietary polyphenols have been reported to have a variety of biological actions, including anticarcinogenic and antioxidant activities. AIM OF THE STUDY:In the present study we investigated the protective effect of dietary polyphenols against N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR) and ben...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-008-0751-6
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Carotenoids in serum vary between countries and within populations with evidence suggesting a qualitative relationship to diet. Breast milk carotenoids furnish a source of vitamin A and potentially provide immunoprotection and other health benefits for infants. There have been numerous studies of milk carote...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-003-0403-9
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. AIM OF THE STUDY:To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel t...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-003-0421-7
更新日期:2003-10-01 00:00:00