Abstract:
PURPOSE:Blueberries are a rich source of anthocyanins (ACNs) and phenolic acids (PA), which are hypothesized to protect against development of atherosclerosis. The present study examined the effect of an ACN- and PA-rich fractions, obtained from a wild blueberry powder, on the capacity to counteract lipid accumulation in macrophages derived from monocytic THP-1 cells. In addition, we tested the capacity of pure ACNs and their metabolites to alter lipid accumulation. METHODS:THP-1-derived macrophages were incubated with fatty acids (500 μM oleic/palmitic acid, 2:1 ratio) and different concentrations (from 0.05 to 10 μg mL(-1)) of ACN- and PA-rich fractions, pure ACN standards (malvidin, delphinidin and cyanidin 3-glucoside), and metabolites (syringic, gallic and protocatechuic acids). Lipid accumulation was quantified with the fluorescent dye Nile red. RESULTS:Lipid accumulation was reduced at all concentrations of the ACN-rich fraction tested with a maximum reduction at 10 μg mL(-1) (-27.4%; p < 0.0001). The PA-rich fraction significantly reduced the lipid accumulation only at the low concentrations from 0.05 µg mL(-1) to 0.3 µg mL(-1), with respect to the control with fatty acids. Supplementation with pure ACN compounds (malvidin and delphinidin-3-glucoside and its metabolic products (syringic and gallic acid)) reduced lipid accumulation especially at the low concentrations, while no significant effect was observed after cyanidin-3-glucoside and protocatechuic acid supplementation. CONCLUSIONS:The results demonstrated a potential role of both the ACN- and PA-rich fractions and single compounds in the lipid accumulation also at concentrations close to that achievable in vivo.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Del Bo' C,Cao Y,Roursgaard M,Riso P,Porrini M,Loft S,Møller Pdoi
10.1007/s00394-015-0835-zsubject
Has Abstractpub_date
2016-02-01 00:00:00pages
171-82issue
1eissn
1436-6207issn
1436-6215pii
10.1007/s00394-015-0835-zjournal_volume
55pub_type
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
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journal_title:European journal of nutrition
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pub_type: 杂志文章,多中心研究
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更新日期:2015-04-01 00:00:00
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-0982-2
更新日期:2016-06-01 00:00:00