Abstract：
:Carotenoids are important micronutrients in the human diet and are present in human serum at micromolar concentrations. In addition to their antioxidant potential, carotenoids obtain physiologically relevant properties such as influencing cellular signal pathways, gene expression or induction of detoxifying enzymes. In this study, we determined the transactivation of PXR by cotransfection with the full-length receptor and a PXR-responsive reporter gene. Carotenoids and retinol revealed a 5-6 fold reporter gene activity in HepG2 cells in comparison to a 7-fold induction by the well-known PXR agonist rifampicin, whereas apo-carotenals and lycopene exerted less or no activation potential. The inductive efficacy was hereby concentration-dependent. In addition, carotenoid- or retinol-mediated gene expression of PXR-responsive genes like CYP3A4/CYP3A7, CYP3A5, MDR-1 and MRP-2 has been determined in HepG2 cells by RT-PCR with up-regulative properties of beta-carotene or retinol being comparable to or even higher than that of rifampicin. In conclusion, PXR-mediated up-regulation of CYP3A4/CYP3A7 and CYP3A5 as well as MDR1 and MRP2 by carotenoids points to a potential interference on the metabolism of xenobiotic and endogenous relevant compounds.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Rühl R,Sczech R,Landes N,Pfluger P,Kluth D,Schweigert FJdoi
10.1007/s00394-004-0475-1keywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
336-43issue
6eissn
1436-6207issn
1436-6215journal_volume
43pub_type
杂志文章abstract：PURPOSE:Several studies in recent years have investigated the relationship between alcohol intake and melanoma risk, with conflicting results. To help clarify this issue, we conducted a literature review and dose-response meta-analysis of studies published until June 30th, 2017, that examined the association between al...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析
doi：10.1007/s00394-018-1613-5
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Experimentally imposed dietary restriction is known to extend the lifespan of rodents, perhaps by slowing the accumulation of oxidative damage that is thought to be one of the causes of aging. AIM OF THE STUDY:We examined the effects of restricted total food intake, and protein and calorie restriction, on D...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-004-0520-0
更新日期：2005-08-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0047-5
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:Excessive consumption of soft drinks is associated with nonalcoholic fatty liver disease (NAFLD). However, the association between soft drinks consumption and NAFLD is unclear in non-Caucasian adults with relatively low soft drinks consumption. The aim of this study was to assess the association between soft dr...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1485-0
更新日期：2018-09-01 00:00:00
abstract：:Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, ...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-012-0331-7
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:The objective of this paper was to evaluate the relationship between urinary concentrations of InsP6, bone mass loss and risk fracture in postmenopausal women. MATERIALS AND METHODS:A total of 157 postmenopausal women were included in the study: 70 had low (≤0.76 μM), 42 intermediate (0.76-1.42 μM) and 45...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章
doi：10.1007/s00394-012-0377-6
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:Adipose tissue-associated chronic inflammation is involved in the pathogenesis of obesity-related diseases. Dietary fatty acids are known to influence inflammatory processes. The aim of this study was to investigate, whether diets with regular fat contents but variable fat qualities affect adipose tissue-associ...
journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Nut consumption is associated with a protective effect against coronary heart disease, partly due to its high antioxidant content. It is hypothesized that the inclusion of nuts in the diet will improve the antioxidant status of subjects with metabolic syndrome who may be vulnerable to impaired antioxidant st...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-007-0647-x
更新日期：2007-04-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-009-0051-9
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Mediterranean diet (MED) is associated with health benefits, yet scarce data exist regarding the role of MED in inflammatory bowel diseases (IBD). Herein, we aimed to evaluate the association between MED and inflammatory markers in patients with IBD after pouch surgery. METHODS:Consecutive patients after po...
journal_title：European journal of nutrition
pub_type： 杂志文章
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abstract：PURPOSE:Manifestation of allergic disease depends on genetic predisposition, diet and commensal microbiota. Genetic polymorphism of mothers determines their breast milk glycan composition. One major determinant is the fucosyltransferase 2 (FUT2, secretor gene) that was shown to be linked to commensal microbiota establi...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2017-04-01 00:00:00
abstract：PURPOSE:The associations between specific carotenoid intake and colorectal cancer risk remain inconsistent. The aim of this study was to examine the association between specific dietary carotenoid intake with colorectal cancer risk in Chinese adults. METHOD:From July 2010 to October 2013, 845 eligible colorectal cance...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0743-7
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid ...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-015-0982-2
更新日期：2016-06-01 00:00:00
abstract：:Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases. Nutrition is likely the most important environmental factor that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-014-0654-7
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine whether grape polyphenols have a "second-meal effect", modulating glucose and lipid elevations in the postprandial period after two successive meals in subjects with obesity. METHODS:A randomized, double-blind, placebo-controlled, acute clinical trial was conducted. Twent...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02451-6
更新日期：2021-01-02 00:00:00
abstract：BACKGROUND:The imbalance of n-6 and n-3 polyunsaturated fatty acids in the maternal diet impairs intestinal barrier development and sensitizes the colon response to inflammatory insults in the young rats. With a view to overcoming this issue, we designed this study to investigate the effect of maternal and neonatal int...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1004-0
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:A recent prospective cohort study revealed that moderate wine consumption but not consumption of other alcoholic beverages is associated with a decreased risk of common cold. In contrast, wine constituents such as ethanol and polyphenols are known to suppress immunity. AIM OF THE STUDY:We investigated wheth...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-002-0384-0
更新日期：2002-12-01 00:00:00
abstract：PURPOSE:Diabetes is a chronic inflammatory disorder resulting in endothelial dysfunction which contributes to peripheral arterial disease and limb ischemia. Leukocytes play critical roles in vascular and tissue remodelling after ischemia. This study investigated the effects of dietary glutamine (GLN) supplementation on...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-01951-4
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:Previous studies have shown that high-dose supplementation with n-3 polyunsaturated fatty acids (PUFAs) may benefit patients with nonalcoholic fatty liver disease (NAFLD), but the association of n-3 PUFAs with NAFLD among individuals with normal diets is only speculative. We investigated the cross-sectional and...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-01953-2
更新日期：2020-04-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02423-w
更新日期：2020-11-05 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02282-5
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Inadequate iodine intake may result in iodine deficiency disorders (IDD). Thus, for more than 50 years, policies for the regulation of salt fortification with iodine have existed in Brazil. In 2003, a study on 6-14-year-old schoolchildren from regions of the state of São Paulo showed a median urinary iodine con...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0239-7
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:In this study, we sought to find the effects and mechanisms of probiotic Lactobacillus casei Zhang (L. casei Zhang) on the pro-inflammatory cytokine production and hepatic inflammatory response in a rat model of acute liver failure induced by lipopolysaccharide (LPS) and d-galactosamine (GalN). METHODS:Male Wi...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0904-3
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:There is considerable variation in incremental circulating 25-hydroxyvitamin D (25OHD) levels on vitamin D supplements, even when similar age groups and identical vitamin D doses are compared. We therefore aimed to investigate the importance of body weight for the dose-response relation in circulating 25OHD. M...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-013-0634-3
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Several epidemiological studies have demonstrated the health benefits of polyphenols, but the associations between polyphenol intake and mortality including total and major causes of death remain unclear. We investigated the associations between subjects' total polyphenol intake and their mortality from all cau...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02136-9
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:Ageing is associated with loss of cognitive function and an increased risk of dementia which is expected to place growing demands on health and long-term care providers. Among multiple causative factors, evidence suggests that cognitive impairment in older subjects may be influenced by diet. The objective of th...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0737-5
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:In obesity and diabetes the liver is highly susceptible to abnormal uptake and storage of fat. In certain individuals hepatic steatosis predisposes to the development of non-alcoholic steatohepatitis (NASH), a disease marked by hepatic inflammation and fibrosis. Although the precise pathophysiology of NASH is u...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-018-1721-2
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Present animal models used to emulate type 2 diabetes may not accurately reflect the metabolic changes that occur in humans. AIM OF THE STUDY:The purpose of this research was to evaluate diets reported to induce insulin resistance and impaired glucose metabolism in rats as a potentially useful model for stu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s003940070016
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1793-z
更新日期：2019-09-01 00:00:00
abstract：BACKGOUND:Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE:To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postpr...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-018-1612-6
更新日期：2019-04-01 00:00:00
