Abstract：
BACKGROUND:Present animal models used to emulate type 2 diabetes may not accurately reflect the metabolic changes that occur in humans. AIM OF THE STUDY:The purpose of this research was to evaluate diets reported to induce insulin resistance and impaired glucose metabolism in rats as a potentially useful model for studying type 2 diabetes. METHODS:Three groups of male Sprague Dawley rats (n=7) were fed either a control diet, based on AIN recommendations (53% cornstarch, 10% sucrose and 7% soybean oil), a high fat diet (25% soybean oil, 35% cornstarch) or a high fructose diet (53% fructose, 10% sucrose) for a 3 month period. Glucose tolerance tests were carried out in week 3 and week 9 of the experiment. At the termination of the experiment, serum insulin, glucose, cholesterol and triacylglycerols were measured. Glucose incorporation into glycogen and glycogen synthase activity were measured in soleus muscles. RESULTS:Similar weight gain was observed for all three groups of rats. Glucose tolerance curves and fasting glucose levels were not significantly different at any time point in the experiment. Insulin levels were unchanged for the controls (171+/-21 pM), high fructose (164+/-16 pM) and high fat (181+/-30 pM) diets. Fasting serum triacylglycerols and cholesterol levels were not significantly elevated by dietary treatment. In soleus muscles, rats on all three diets had a significant increase in glycogen synthesis in response to insulin, but synthesis was similar in all three groups. Glycogen synthase activity was also not significantly affected by long-term dietary intervention. CONCLUSIONS:In this study, healthy Sprague Dawley rats fed high fat or high fructose diets for 3 months adapted to the nutritional intervention without developing classical signs of insulin resistance and impaired glucose tolerance.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Stark AH,Timar B,Madar Zdoi
10.1007/s003940070016keywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
229-34issue
5eissn
1436-6207issn
1436-6215journal_volume
39pub_type
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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更新日期：2013-10-01 00:00:00
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更新日期：2018-04-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2017-09-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0778-3
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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更新日期：2001-12-01 00:00:00
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journal_title：European journal of nutrition
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更新日期：2020-06-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1793-z
更新日期：2019-09-01 00:00:00
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-017-1476-1
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:Pomegranate fruit, Punica granatum L. (Punicaceae), and its constituents have been shown to inhibit inflammation. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. METHODS:An enzyme immunoassay (EIA) was used to measure prostag...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0984-0
更新日期：2016-06-01 00:00:00
