Abstract:
PURPOSE:The aim of this study was to determine whether grape polyphenols have a "second-meal effect", modulating glucose and lipid elevations in the postprandial period after two successive meals in subjects with obesity. METHODS:A randomized, double-blind, placebo-controlled, acute clinical trial was conducted. Twenty-five obese subjects (BMI = ≥ 30 and < 40 kg/m2) were randomly divided into two groups. At an initial visit, blood was collected in a fasting state and the subjects received breakfast and 46 g of either grape powder (equivalent to 252 g fresh grapes) or placebo, both solved in water. Lunch was provided 5 h later and then blood was collected after 0, 30, 60, 120, 180, 240, 300, 330, 360, and 420 min since arrival. Two weeks later, at a second visit, the subjects received the other powder. The following were determined: glucose, insulin, triglycerides, uric acid, blood count, hemoglobin, viscosity, antioxidant capacity, and satiety perception. RESULTS:Postprandial increases were observed as expected in, for example, glucose and triglycerides after breakfast and lunch. The grape powder supplementation did not cause any significant modification compared to placebo, in these parameters; nor did it significantly modify plasma antioxidant capacity in the 6 h postprandial period. DISCUSSION:Single grape powder supplementation did not modify postprandial responses in obese subjects, probably because the polyphenol dose was insufficient to induce such an effect. The result of a combination of grape with other polyphenol-rich products or chronic supplementation with grape powder on postprandial responses remains to be elucidated. TRIAL REGISTRATION NUMBER:www.clinicaltrials.gov , NCT03741218.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
García-Díez E,Cuesta-Hervás M,Veses-Alcobendas AM,Alonso-Gordo Ó,García-Maldonado E,Martínez-Suárez M,Herranz B,Vaquero MP,Álvarez MD,Pérez-Jiménez Jdoi
10.1007/s00394-020-02451-6subject
Has Abstractpub_date
2021-01-02 00:00:00eissn
1436-6207issn
1436-6215pii
10.1007/s00394-020-02451-6pub_type
杂志文章abstract:PURPOSE:The secoiridoid oleuropein, as found in olives and olive leaves, modulates some biomarkers of diabetes risk in vivo. A possible mechanism may be to attenuate sugar digestion and absorption. METHODS:We explored the potential of oleuropein, prepared from olive leaves in a water soluble form (OLE), to inhibit dig...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2019-04-01 00:00:00
abstract:PURPOSE:Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effe...
journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
pub_type: 杂志文章
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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更新日期:2020-09-10 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2016-09-01 00:00:00
abstract:PURPOSE:The relationship between 100% fruit juice (100%FJ) consumption and cardiovascular risk is object of debate: indeed, recently published investigations provided new but discrepant evidence on this important question and International dietary guidelines are not in agreement on recommendations about fruit juice con...
journal_title:European journal of nutrition
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更新日期:2020-11-04 00:00:00
abstract:PURPOSE:Quercetin is one of potential antidiabetic substances because of its powerful antioxidant and anti-inflammatory actions. The purpose of this study is to estimate daily quercetin intake and assess the relationship between dietary quercetin intake and the prevalence of type 2 diabetes mellitus (T2DM) in a Chinese...
journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-005-0556-9
更新日期:2006-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-018-1695-0
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Uroguanylin (UGN) is a 16 amino acid peptide produced mainly by intestinal epithelial cells. Nutrients intake increases circulating levels of prouroguanylin that is processed and converted to UGN to activate the guanylyl cyclase 2C receptor (GUCY2C). Given that the UGN-GUCY2C system has been proposed as a novel...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0869-2
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Epidemiological studies directly examining the association between habitual yoghurt consumption and mental health remain scarce. The aim of this study is to investigate the association of yoghurt consumption with depressive symptoms in adults. METHODS:This is a cross-sectional study of 19,596 Chinese adults (m...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0268-2
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Deficiency of micronutrients is common in refugee populations. OBJECTIVES:Identify deficiencies and whether provided supplements and wheat flour fortified with 10 micronutrients impacts upon status among breast-feeding women from Maela refugee camp. METHODS:Two sequential cross-sectional studies were condu...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
abstract:PURPOSE:To assess the effectiveness of a dietary intervention combined with fortified dairy products on bone metabolism and bone mass indices in postmenopausal women. METHODS:Forty postmenopausal women (55-65 years old) were equally randomized into a dietary group (DG), receiving daily and for 30 months, 1,200 mg of c...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2011-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2014-01-01 00:00:00