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Dietary fat quality in regular fat diets has minor effects on biomarkers of inflammation in obese Zucker rats.

Abstract：

PURPOSE:Adipose tissue-associated chronic inflammation is involved in the pathogenesis of obesity-related diseases. Dietary fatty acids are known to influence inflammatory processes. The aim of this study was to investigate, whether diets with regular fat contents but variable fat qualities affect adipose tissue-associated inflammation through the fatty acid composition of mesenteric adipose tissue (MAT). METHODS:Obese Zucker rats were fed diets containing 7 % wt:wt rapeseed oil, corn oil, or lard for 10 weeks. Fatty acid composition and endocrine function regarding adipokines and cytokines of MAT, number of total CD3(+) T cells, and cytokine secretion of mesenteric lymph node (MLN)-derived lymphocytes were determined. Local effects in MAT and MLN were compared to systemic effects assessed in serum and peripheral blood mononuclear cells. RESULTS:Fatty acid composition of MAT reflected dietary fatty acid intake, without affecting endocrine function. Feeding the lard diet for 10 weeks increased the serum adiponectin and TNF-α secretion of blood lymphocytes, whereas CD3(+) T cells in blood were decreased. No effects were seen for the secretion of adipokines and cytokines from MAT, the amount of T cells in MLN, and cytokine secretion of MLN lymphocytes. CONCLUSIONS:In conclusion, feeding obese rats a diet with regular fat content but variable fat sources for 10 weeks, changed the fatty acid composition of MAT but not its secretory properties or MLN functions. Although the local immune system was not influenced, lard-feeding induced minor changes in systemic immune function.

journal_name

Eur J Nutr

journal_title

European journal of nutrition

authors

Graf D,Barth SW,Bub A,Narr J,Rüfer CE,Watzl B,Seifert S

doi

10.1007/s00394-013-0518-6

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

211-9

issue

1

eissn

1436-6207

issn

1436-6215

journal_volume

53

pub_type

杂志文章

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