Abstract:
PURPOSE:Resveratrol is a polyphenol present in red wine for which the capability of directly interfering with the hallmark of Alzheimer's disease (AD), i.e. toxic β-amyloid protein (Aβ) aggregation, has been shown recently. Since the stimulation of proteostasis could explain reduced Aβ-aggregation, we searched for proteostasis targets of resveratrol. METHODS:The transgenic Caenorhabditis elegans strain CL2006, expressing Aβ1-42 under control of a muscle-specific promoter and responding to Aβ-toxicity with paralysis, was used as a model. Target identification was accomplished through specific knockdowns of proteostasis genes by RNA interference. Effects of resveratrol on protein aggregation were identified using ProteoStat(®) Detection Reagent, and activation of proteasomal degradation by resveratrol was finally proven using a specific fluorogenic peptide substrate. RESULTS:Resveratrol at a concentration of 100 µM caused a 40 % decrease in paralysis. UBL-5 involved in unfolded protein response (UPR) in mitochondria proved to be necessary for the prevention of Aβ-toxicity by resveratrol. Also XBP-1, which represents an endoplasmic reticulum-resident factor involved in UPR, was identified to be necessary for the effects of resveratrol. Regarding protein degradation pathways, the inhibition of macroautophagy and chaperone-mediated autophagy prevented resveratrol from reducing paralysis as did the inhibition of proteasomal degradation. Finally, resveratrol reduced the amount of lysosomes, suggesting increased flux of proteins through the autophagy pathways and activated proteasomal degradation. CONCLUSIONS:Resveratrol reduces the Aβ-induced toxicity in a C. elegans model of AD by targeting specific proteins involved in proteostasis and thereby reduces the amount of aggregated Aβ.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Regitz C,Fitzenberger E,Mahn FL,Dußling LM,Wenzel Udoi
10.1007/s00394-015-0894-1subject
Has Abstractpub_date
2016-03-01 00:00:00pages
741-747issue
2eissn
1436-6207issn
1436-6215pii
10.1007/s00394-015-0894-1journal_volume
55pub_type
杂志文章abstract:BACKGROUND:Low birth weight (LBW) associates with increased risk of developing type 2 diabetes. LBW individuals exhibit disproportionately reduced peripheral insulin action and increased fat oxidation after a 5-day high-fat overfeeding (HFO) challenge. Furthermore, LBW men exhibit increased nocturnal fat oxidation duri...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-1018-7
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Rooibos tea (Aspalathus linearis) is commonly used for hyperactive gastrointestinal, respiratory and cardiovascular disorders. AIM OF STUDY:The aqueous extract of Rooibos tea (RT) was studied for the possible bronchodilator, antispasmodic and blood pressure lowering activities in an attempt to rationalize s...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0620-0
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:At the present time the recommended daily intake or allowance (RDA) and the safe upper level (UL) of intake of micronutrients are given as single values. The recommended daily intake is considered to cover the requirements of 97.5% of the population while the safe upper level is a value for the whole populat...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-007-0691-6
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:Experimental investigations in rodents have contributed significantly to our current understanding of the potential importance of the gut microbiome and brain interactions for neurotransmitter expression, neurodevelopment, and behaviour. However, clinical evidence to support such interactions is still scarce. T...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-018-1732-z
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat's pups; on yield, cytokines and milk composition was studied. METHODS:Lactobacillus plantarum L...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1628-y
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To investigate whether early introduction of complementary foods (CF) is associated with an increased risk of overweight during childhood, and whether this association differs between formula-fed and breastfed infants. METHODS:We included 2611 participants that were born at term from a Dutch population-based b...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1639-8
更新日期:2018-08-01 00:00:00
abstract::In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected. ...
journal_title:European journal of nutrition
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00394-018-1800-4
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Manifestation of allergic disease depends on genetic predisposition, diet and commensal microbiota. Genetic polymorphism of mothers determines their breast milk glycan composition. One major determinant is the fucosyltransferase 2 (FUT2, secretor gene) that was shown to be linked to commensal microbiota establi...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-016-1180-6
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Our aim was to investigate the effect of the dietary fat on the two main adipose tissue functions, endocrine and lipid store, by analyzing the adipose tissue gene expression from metabolic syndrome patients. METHODS:A randomized...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-013-0570-2
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Current evidence accounts for the role of (poly)phenolic compounds in the prevention of non-communicable diseases. Detailed information on population-level intakes is required to translate these findings into recommendations. This work aimed to estimate (poly)phenol intake in the UK population using data from a...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1862-3
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:A recent prospective cohort study revealed that moderate wine consumption but not consumption of other alcoholic beverages is associated with a decreased risk of common cold. In contrast, wine constituents such as ethanol and polyphenols are known to suppress immunity. AIM OF THE STUDY:We investigated wheth...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-002-0384-0
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Mediterranean diet (MED) is associated with health benefits, yet scarce data exist regarding the role of MED in inflammatory bowel diseases (IBD). Herein, we aimed to evaluate the association between MED and inflammatory markers in patients with IBD after pouch surgery. METHODS:Consecutive patients after po...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02158-3
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:Individuals with favorable levels of readily measured cardiovascular disease (CVD) risk factors (low risk, LR) experience low long-term rates of CVD mortality and greater longevity. The purpose of the current study was to compare nutrient/food intakes of LR participants with participants not LR in the INTERMAP ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0268-2
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:In metabolic syndrome, the composition of gut microbiota has been disrupted, and is associated with left ventricular (LV) dysfunction. Several types of prebiotics, probiotics, and synbiotics have been shown to exert cardioprotection by restoring gut microbiota from dysbiosis and reducing systemic inflammation. ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1482-3
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:Tryptophan is an essential amino acid, precursor of serotonin. Serotonin (5HT) regulates the secretion of pituitary growth hormone (GH), which in turn stimulates the liver to produce insulin-like growth factor-I (IGF-I) that is necessary for development and growth. The aim of our study was to investigate the ef...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0528-4
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:Epidemiologic evidence on the potential effects of dietary acid load on frailty is lacking. This cross-sectional study examined the association between dietary acid load and frailty. METHODS:This study was based on self-reported data obtained from 2176 Japanese women aged 65-94 years. Dietary acid load was c...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1449-4
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:It is thought that total energy intake in women is increased during the luteal versus follicular phase of the menstrual cycle; however, less is understood regarding changes in diet composition (i.e., macro- and micronutrient intakes) across the cycle. The aim of this study was to investigate changes in macronut...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0931-0
更新日期:2016-04-01 00:00:00
abstract:AIM OF THIS STUDY:was to assess the validity of a 3-day estimated dietary record, especially developed for the longitudinal study on nutrition and health status in an aging population (aged > or = 60 years) in Giessen, Germany. METHODS:The dietary record comprises 146 food items. Portion sizes of the foods consumed we...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s003940050066
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...
journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
doi:10.1007/s00394-012-0473-7
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:To estimate total sodium (Na) and potassium (K) intake using non-fasting morning urine specimens among Lebanese elementary (6-10 year old) schoolchildren. METHOD:A national cross-sectional study was conducted. A multistage cluster sampling procedure was used to select a representative sample of 1403 healthy ch...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1164-6
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To investigate whether age influences colonic polyphenol metabolism. METHODS:Healthy participants, younger (n = 8; 23-43 years) and older (n = 13; 51-76 years), followed a 3-day low-polyphenol diet (LPD) and a 3-day high-polyphenol diet (HPD). Urinary phenolic acids (PA), short chain fatty acids (SCFA), pH and...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1625-1
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To assess the effect of medium-chain fatty acid (MCFA)-rich mustard oil and polyunsaturated fatty acid (PUFA)-rich mustard oil on erythrocyte membrane composition and osmotic fragility in normal and hypercholesterolemic rats. METHOD:Membrane composition was analyzed using standard kits. Osmotic fragility was d...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-010-0150-7
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:Fruit and vegetable (FV) consumption and salt intake are known dietary influences on blood pressure (BP) in adults, but data on their long-term relevance during growth for later BP are rare. We aimed to examine the independent and concomitant influences of adolescent FV and salt intakes on BP in young adulthood...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0804-y
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders. The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can i...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02382-2
更新日期:2020-09-10 00:00:00
abstract:PURPOSES:Hepatic lipid overloading induces lipotoxicity which can cause hepatocyte damage, fibrosis, and eventually progress to cirrhosis, which is associated with nonalcoholic fatty liver disease. Adiponectin receptors play important roles in regulating lipid metabolism. In this study, we used a lentivirus system to o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0594-7
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Reducing postprandial hyperglycemia has beneficial effects on diabetes-related risk factors, but the magnitude of the reduction needed to achieve such an effect is unknown. The purpose of the study was to quantify the relationship of acute glucose and insulin postprandial responses with longer-term effects on d...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02240-1
更新日期:2020-04-10 00:00:00
abstract:BACKGROUND:Choline, docosahexaenoic acid (DHA), and arachidonic acid (ARA) are essential to fetal development, particularly of the brain. These components are actively enriched in the fetus. Deprivation from placental supply may therefore result in impaired accretion in preterm infants. OBJECTIVE:To determine choline,...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-016-1220-2
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Adherence to Mediterranean diet has been shown to be associated with a better health and greater survival. The aim of the present study was to identify change-points in the relationship between food groups composing Mediterranean diet and overall mortality. METHODS:The population of the Greek EPIC prospecti...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0202-7
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Due to their lower glycaemic index, leguminous seeds affect human carbohydrate metabolism lesser than do cereals. Problems, however, could arise from side effects, e.g., increasing flatulence. AIM OF THE STUDY AND METHODS:In 26 healthy subjects, metabolic and symptomatic responses following acute ingestion ...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s003940050060
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify metabolomic signatures re...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02177-5
更新日期:2020-12-01 00:00:00