Choline and polyunsaturated fatty acids in preterm infants' maternal milk.

Abstract:

BACKGROUND:Choline, docosahexaenoic acid (DHA), and arachidonic acid (ARA) are essential to fetal development, particularly of the brain. These components are actively enriched in the fetus. Deprivation from placental supply may therefore result in impaired accretion in preterm infants. OBJECTIVE:To determine choline, choline metabolites, DHA, and ARA in human breast milk (BM) of preterm infants compared to BM of term born infants. DESIGN:We collected expressed BM samples from 34 mothers (N = 353; postnatal day 6-85), who had delivered 35 preterm infants undergoing neonatal intensive care (postmenstrual age 30 weeks, range 25.4-32.0), and from mothers after term delivery (N = 9; postnatal day 6-118). Target metabolites were analyzed using tandem mass spectrometry and gas chromatography and reported as medians and 25th/75th percentiles. RESULTS:In BM, choline was mainly present in the form of phosphocholine and glycerophosphocholine, followed by free choline, phosphatidylcholine, sphingomyelin, and lyso-phosphatidylcholine. In preterm infants' BM total choline ranged from 61 to 360 mg/L (median: 158 mg/L) and was decreased compared to term infants' BM (range 142-343 mg/L; median: 258 mg/L; p < 0.01). ARA and DHA comprised 0.81 (range: 0.46-1.60) and 0.43 (0.15-2.42) % of total preterm BM lipids, whereas term BM values were 0.68 (0.52-0.88) and 0.35 (0.18-0.75) %, respectively. Concentrations of all target parameters decreased after birth, and frequently 150 ml/kg/d BM did not meet the estimated fetal accretion rates. CONCLUSIONS:Following preterm delivery, BM choline concentrations are lower, whereas ARA and DHA levels are comparable versus term delivery. Based on these findings we suggest a combined supplementation of preterm infants' BM with choline, ARA and DHA combined to improve the nutritional status of preterm infants. STUDY REGISTRATION:This study was registered at www.clinicaltrials.gov. Identifier: NCT01773902.

journal_name

Eur J Nutr

authors

Maas C,Franz AR,Shunova A,Mathes M,Bleeker C,Poets CF,Schleicher E,Bernhard W

doi

10.1007/s00394-016-1220-2

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

1733-1742

issue

4

eissn

1436-6207

issn

1436-6215

pii

10.1007/s00394-016-1220-2

journal_volume

56

pub_type

杂志文章,随机对照试验
  • Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice.

    abstract:PURPOSE:Although several researches have demonstrated that rooibos extract has hypoglycemic effect, the role of aspalathin, a main polyphenol in the extract, remains unclear. Our aims were to find specific mechanisms for anti-diabetic action of aspalathin employing a rat skeletal muscle-derived cell line (L6 myocytes) ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-012-0466-6

    authors: Son MJ,Minakawa M,Miura Y,Yagasaki K

    更新日期:2013-09-01 00:00:00

  • Polyunsaturated fatty acids and risk of Alzheimer's disease: a Mendelian randomization study.

    abstract:PURPOSE:Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer's disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. METHODS:We used summary statistics data for single-nucleotide polymorphisms associated with plasm...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-019-02126-x

    authors: Tomata Y,Larsson SC,Hägg S

    更新日期:2020-06-01 00:00:00

  • Coffee consumption and the risk of cutaneous melanoma: a meta-analysis.

    abstract:PURPOSE:Results from epidemiologic studies on coffee consumption and the risk of cutaneous melanoma are inconsistent. We conducted a meta-analysis to assess the associations between the consumption of total coffee, caffeinated coffee and decaffeinated coffee and the risk of cutaneous melanoma, respectively. METHODS:A ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00394-015-1139-z

    authors: Wang J,Li X,Zhang D

    更新日期:2016-06-01 00:00:00

  • Does equol production determine soy endocrine effects?

    abstract::Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,评审

    doi:10.1007/s00394-012-0331-7

    authors: Shor D,Sathyapalan T,Atkin SL,Thatcher NJ

    更新日期:2012-06-01 00:00:00

  • Alcohol consumption and the risk of coronary heart disease in postmenopausal women with diabetes: Women's Health Initiative Observational Study.

    abstract:BACKGROUND:Although several observational studies have consistently reported an inverse association between moderate alcohol consumption and risk of coronary heart disease (CHD), it is yet not well established if this association also exists among people with type 2 diabetes. The aim of this study is to evaluate the as...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-009-0065-3

    authors: Rajpathak SN,Freiberg MS,Wang C,Wylie-Rosett J,Wildman RP,Rohan TE,Robinson JG,Liu S,Wassertheil-Smoller S

    更新日期:2010-06-01 00:00:00

  • Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor.

    abstract::Carotenoids are important micronutrients in the human diet and are present in human serum at micromolar concentrations. In addition to their antioxidant potential, carotenoids obtain physiologically relevant properties such as influencing cellular signal pathways, gene expression or induction of detoxifying enzymes. I...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-004-0475-1

    authors: Rühl R,Sczech R,Landes N,Pfluger P,Kluth D,Schweigert FJ

    更新日期:2004-12-01 00:00:00

  • Alpha-lipoic acid preserves the structural and functional integrity of red blood cells by adjusting the redox disturbance and decreasing O-GlcNAc modifications of antioxidant enzymes and heat shock proteins in diabetic rats.

    abstract:PURPOSE:The aim of this study was to investigate whether the daily administration of α-lipoic acid (LA) during 4 weeks prevents the redox disturbance in red blood cells (RBC) described in diabetes METHODS:Multiple low-dose streptozotocin (STZ) diabetes was induced in rats by the administration of 40 mg/kg STZ intraper...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-011-0275-3

    authors: Mirjana M,Jelena A,Aleksandra U,Svetlana D,Nevena G,Jelena M,Goran P,Melita V

    更新日期:2012-12-01 00:00:00

  • Lack of oxidative stress in a selenium deficient area in Ivory Coast--potential nutritional antioxidant role of crude palm oil.

    abstract:BACKGROUND:Previous studies have described an important selenium deficiency in a mountain region (Glanle) in the west of Ivory Coast. AIM OF THE STUDY:To assess the antioxidant capacity of subjects from a selenium deficient area in Ivory Coast (Glanle region). METHODS:This study involved 57 subjects, 18 to 69 years o...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-004-0484-0

    authors: Tiahou G,Maire B,Dupuy A,Delage M,Vernet MH,Mathieu-Daudé JC,Michel F,Sess ED,Cristol JP

    更新日期:2004-12-01 00:00:00

  • Chronic treatment with prebiotics, probiotics and synbiotics attenuated cardiac dysfunction by improving cardiac mitochondrial dysfunction in male obese insulin-resistant rats.

    abstract:PURPOSE:In metabolic syndrome, the composition of gut microbiota has been disrupted, and is associated with left ventricular (LV) dysfunction. Several types of prebiotics, probiotics, and synbiotics have been shown to exert cardioprotection by restoring gut microbiota from dysbiosis and reducing systemic inflammation. ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-017-1482-3

    authors: Tunapong W,Apaijai N,Yasom S,Tanajak P,Wanchai K,Chunchai T,Kerdphoo S,Eaimworawuthikul S,Thiennimitr P,Pongchaidecha A,Lungkaphin A,Pratchayasakul W,Chattipakorn SC,Chattipakorn N

    更新日期:2018-09-01 00:00:00

  • Integrity of erythrocytes of hypercholesterolemic and normocholesterolemic rats during ingestion of different structured lipids.

    abstract:PURPOSE:To assess the effect of medium-chain fatty acid (MCFA)-rich mustard oil and polyunsaturated fatty acid (PUFA)-rich mustard oil on erythrocyte membrane composition and osmotic fragility in normal and hypercholesterolemic rats. METHOD:Membrane composition was analyzed using standard kits. Osmotic fragility was d...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-010-0150-7

    authors: Sengupta A,Ghosh M

    更新日期:2011-09-01 00:00:00

  • Association between erythrocyte fatty acids in de novo lipogenesis pathway and DXA-derived body fat and trunk fat distribution in Chinese adults: a prospective study.

    abstract:PURPOSE:Higher levels of fatty acids (FAs) in the de novo lipogenesis (DNL) pathway might be associated with higher levels of fat mass (FM), while limited evidence is available from the general population. We aimed to examine the associations between DNL-FAs and body fat and fat distribution in a general population of ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-018-1866-z

    authors: Zeng FF,Chen ZY,Zheng JS,Lin JS,Li YH,Qiu R,Wang C,Sun LL,Chen YM

    更新日期:2019-12-01 00:00:00

  • Implication of vitamin A deficiency on vascular injury related to inflammation and oxidative stress. Effects on the ultrastructure of rat aorta.

    abstract:BACKGROUND:Vitamin A deficiency induces activation of NF-kB and impairs activities of antioxidant enzymes in aorta. AIM OF THE STUDY:We study the effect of vitamin A deficiency on the aorta histoarchitecture and the possibly contribution of its prooxidant and inflammatory effects to artery alterations. METHODS:Twenty...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-011-0198-z

    authors: Gatica LV,Oliveros LB,Pérez Díaz MF,Domínguez NS,Fornes MW,Gimenez MS

    更新日期:2012-02-01 00:00:00

  • Early introduction of complementary foods and childhood overweight in breastfed and formula-fed infants in the Netherlands: the PIAMA birth cohort study.

    abstract:PURPOSE:To investigate whether early introduction of complementary foods (CF) is associated with an increased risk of overweight during childhood, and whether this association differs between formula-fed and breastfed infants. METHODS:We included 2611 participants that were born at term from a Dutch population-based b...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-018-1639-8

    authors: Pluymen LPM,Wijga AH,Gehring U,Koppelman GH,Smit HA,van Rossem L

    更新日期:2018-08-01 00:00:00

  • Neuroprotection by extract of Petasites japonicus leaves, a traditional vegetable, against oxidative stress in brain of mice challenged with kainic acid.

    abstract:BACKGROUND:Reactive oxygen radicals have been implicated in the pathophysiology of many neurologic disorders and brain dysfunctions. Kainic acid has been used as a model agent for the study of neurotoxicity of various excitatory amino acids, since it induces neuronal damage through excessive production of reactive oxyg...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-005-0565-8

    authors: Sok DE,Oh SH,Kim YB,Kang HG,Kim MR

    更新日期:2006-03-01 00:00:00

  • The effect of three different ad libitum diets for weight loss maintenance: a randomized 18-month trial.

    abstract:PURPOSE:To test the effect of three diets in their ability to sustain weight loss and improve type 2 diabetes (T2D) and cardiovascular disease (CVD) risk markers after 18-month intervention. METHODS:Following a ≥8 % weight loss, 131 healthy, overweight/obese (BMI ± SD 31.5 ± 2.6 kg/m2) men (n = 55) and women (n = 76) ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-015-1116-6

    authors: Due A,Larsen TM,Mu H,Hermansen K,Stender S,Toubro S,Allison DB,Astrup A

    更新日期:2017-03-01 00:00:00

  • No difference in platelet activation or inflammation markers after diets rich or poor in vegetables, berries and apple in healthy subjects.

    abstract:BACKGROUND:High intake of vegetables and fruits is associated with decreased risk of coronary heart disease. Part of these cardioprotective effects may be mediated via the antithrombotic effects of compounds found in vegetables and fruits, such as flavonoids. AIM OF THE STUDY:To study the effects of high and low intak...

    journal_title:European journal of nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00394-004-0456-4

    authors: Freese R,Vaarala O,Turpeinen AM,Mutanen M

    更新日期:2004-06-01 00:00:00

  • Low FODMAP diet significantly improves IBS symptoms: an Irish retrospective cohort study.

    abstract:INTRODUCTION:There is growing evidence that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) improves symptoms in irritable bowel syndrome (IBS) patients. We aimed to retrospectively investigate the effects of this diet in Irish IBS cohort over a 12-month follow-up period...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-019-02074-6

    authors: Nawawi KNM,Belov M,Goulding C

    更新日期:2020-08-01 00:00:00

  • Cognitive effects following acute wild blueberry supplementation in 7- to 10-year-old children.

    abstract:PURPOSE:Previously, anthocyanin-rich blueberry treatments have shown positive effects on cognition in both animals and human adults. However, little research has considered whether these benefits transfer to children. Here we describe an acute time-course and dose-response investigation considering whether these cognit...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-015-1029-4

    authors: Whyte AR,Schafer G,Williams CM

    更新日期:2016-09-01 00:00:00

  • Dietary glycemic index, glycemic load and risk of age-related cataract extraction: a case-control study in Italy.

    abstract:PURPOSE:Although a role of glycemic index (GI) and glycemic load (GL) in age-related cataract development is plausible, a few studies, all conducted in USA or Australia, provided results on this issue. The aim of the present study was to provide new original data from a Mediterranean population. METHODS:We analyzed da...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00394-014-0731-y

    authors: Turati F,Filomeno M,Galeone C,Serraino D,Bidoli E,La Vecchia C

    更新日期:2015-04-01 00:00:00

  • Water intake and post-exercise cognitive performance: an observational study of long-distance walkers and runners.

    abstract:PURPOSE:The impact of diet on endurance performance and cognitive function has been extensively researched in controlled settings, but there are limited observational data in field situations. This study examines relationships between nutrient intake and cognitive function following endurance exercise amongst a group o...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-012-0364-y

    authors: Benefer MD,Corfe BM,Russell JM,Short R,Barker ME

    更新日期:2013-03-01 00:00:00

  • Micronutrient status and intake in omnivores, vegetarians and vegans in Switzerland.

    abstract:PURPOSE:Vegetarian and vegan diets have gained popularity in Switzerland. The nutritional status of individuals who have adopted such diets, however, has not been investigated. The aim of this study was to assess the intake and status of selected vitamins and minerals among vegetarian and vegan adults living in Switzer...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-015-1079-7

    authors: Schüpbach R,Wegmüller R,Berguerand C,Bui M,Herter-Aeberli I

    更新日期:2017-02-01 00:00:00

  • Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota.

    abstract:BACKGROUND:Diet has an important role in host-microbiome interplay, which may result in intestinal permeability changes and physiopathological effects at a systemic level. Despite the importance of maternal microbiota as the main contributor to the initial microbial seeding, little is known about the effects of materna...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-020-02337-7

    authors: Selma-Royo M,García-Mantrana I,Calatayud M,Parra-Llorca A,Martínez-Costa C,Collado MC

    更新日期:2020-07-29 00:00:00

  • Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways.

    abstract:PURPOSE:This study was aimed to determine the impact of hydroxytyrosol (HT), a minor compound found in olive oil, on breast cancer stem cells (BCSCs) and the migration capacity of triple-negative breast cancer (TNBC) cell lines through the alteration of epithelial-to-mesenchymal transition (EMT) and embryonic signaling...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-018-1864-1

    authors: Cruz-Lozano M,González-González A,Marchal JA,Muñoz-Muela E,Molina MP,Cara FE,Brown AM,García-Rivas G,Hernández-Brenes C,Lorente JA,Sanchez-Rovira P,Chang JC,Granados-Principal S

    更新日期:2019-12-01 00:00:00

  • Inulin-enriched pasta affects lipid profile and Lp(a) concentrations in Italian young healthy male volunteers.

    abstract:BACKGROUND:Inulin has been suggested to have beneficial effects on lipids, especially on triglyceridemia. Few data are available about the effects of inulin on Lipoprotein(a), a low-density lipoprotein-like particle considered as an independent risk factor for atherosclerosis. Adding inulin to pasta could be a preventi...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-008-0748-1

    authors: Russo F,Chimienti G,Riezzo G,Pepe G,Petrosillo G,Chiloiro M,Marconi E

    更新日期:2008-12-01 00:00:00

  • Vitamin E supplementation does not increase the vitamin C radical concentration at rest and after exhaustive exercise in healthy male subjects.

    abstract:BACKGROUND:Extensive exercise may promote the formation of reactive oxygen species and subsequently contribute to tissue damage. A compound which can protect cells and tissues is vitamin E. The vitamin E radical, formed during the radical scavenging process, can be reduced by vitamin C resulting in a higher level of th...

    journal_title:European journal of nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00394-003-0414-6

    authors: Schneider M,Niess AM,Rozario F,Angres C,Tschositsch K,Golly I,Battenfeld N,Schäffer M,Northoff H,Dickhuth HH,Fehrenbach E,Trommer WE,Biesalski HK

    更新日期:2003-08-01 00:00:00

  • Maternal diet, bioactive molecules, and exercising as reprogramming tools of metabolic programming.

    abstract::Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases. Nutrition is likely the most important environmental factor that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,评审

    doi:10.1007/s00394-014-0654-7

    authors: Mathias PC,Elmhiri G,de Oliveira JC,Delayre-Orthez C,Barella LF,Tófolo LP,Fabricio GS,Chango A,Abdennebi-Najar L

    更新日期:2014-04-01 00:00:00

  • Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial.

    abstract:PURPOSE:Observational studies have frequently reported that low blood folate concentrations are associated with poor cognitive performance. Our previous studies have shown the potential beneficial effect on the metabolite levels of methionine cycle and peripheral blood inflammatory cytokines from 6- and 12-month folic ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-017-1598-5

    authors: Ma F,Li Q,Zhou X,Zhao J,Song A,Li W,Liu H,Xu W,Huang G

    更新日期:2019-02-01 00:00:00

  • Nutrient and food intakes of middle-aged adults at low risk of cardiovascular disease: the international study of macro-/micronutrients and blood pressure (INTERMAP).

    abstract:PURPOSE:Individuals with favorable levels of readily measured cardiovascular disease (CVD) risk factors (low risk, LR) experience low long-term rates of CVD mortality and greater longevity. The purpose of the current study was to compare nutrient/food intakes of LR participants with participants not LR in the INTERMAP ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-011-0268-2

    authors: Shay CM,Stamler J,Dyer AR,Brown IJ,Chan Q,Elliott P,Zhao L,Okuda N,Miura K,Daviglus ML,Van Horn L

    更新日期:2012-12-01 00:00:00

  • Validation of a self-administered 3-day estimated dietary record for use in the elderly.

    abstract:AIM OF THIS STUDY:was to assess the validity of a 3-day estimated dietary record, especially developed for the longitudinal study on nutrition and health status in an aging population (aged > or = 60 years) in Giessen, Germany. METHODS:The dietary record comprises 146 food items. Portion sizes of the foods consumed we...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s003940050066

    authors: Lührmann PM,Herbert BM,Gaster C,Neuhäuser-Berthold M

    更新日期:1999-10-01 00:00:00

  • Vitamin E reduces lipid peroxidation in experimental hepatotoxicity in rats.

    abstract:BACKGROUND AND AIMS:Lipid peroxidation is believed to be involved in the pathophysiology of a number of diseases and in the process of aging. This study investigates the effects of dietary supplementation with vitamin E (20 g/kg diet of all-rac-alpha-tocopheryl succinate for 3 weeks) on both non-enzymatic and enzymatic...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/pl00007381

    authors: Södergren E,Cederberg J,Vessby B,Basu S

    更新日期:2001-02-01 00:00:00