Abstract：
PURPOSE:Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer's disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. METHODS:We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of n-6 PUFAs (linoleic acid, arachidonic acid) and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid), and the corresponding data for AD from a genome-wide association meta-analysis of 63,926 individuals (21,982 diagnosed AD cases, 41,944 controls). RESULTS:None of the genetically predicted PUFAs was significantly associated with AD risk; odds ratios (95% confidence interval) per 1 SD increase in PUFA levels were 0.98 (0.93, 1.03) for linoleic acid, 1.01 (0.98, 1.05) for arachidonic acid, 0.96 (0.88, 1.06) for alpha-linolenic acid, 1.03 (0.93, 1.13) for eicosapentaenoic acid, 1.03 (0.97, 1.09) for docosapentaenoic acid, and 1.01 (0.81, 1.25) for docosahexaenoic acid. CONCLUSIONS:This study did not support the hypothesis that PUFAs decrease AD risk.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Tomata Y,Larsson SC,Hägg Sdoi
10.1007/s00394-019-02126-xsubject
Has Abstractpub_date
2020-06-01 00:00:00pages
1763-1766issue
4eissn
1436-6207issn
1436-6215pii
10.1007/s00394-019-02126-xjournal_volume
59pub_type
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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更新日期：2012-06-01 00:00:00
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journal_title：European journal of nutrition
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