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Dietary supplementation with different vitamin C doses: no effect on oxidative DNA damage in healthy people.

Abstract：

BACKGROUND:Antioxidants are believed to prevent many types of disease. Some previous studies suggest that dietary supplementation with vitamin C results in a decrease in the level of one of the markers of oxidative damage-8-oxoguanine in the DNA of peripheral blood mononuclear cells (PBMC). AIM OF TRIAL: To investigate the effect of different dose levels of dietary supplementation with vitamin C on oxidative DNA damage. METHODS:A randomised double-blind placebo-controlled trial was carried out using three different levels (80, 200 and 400 mg) of dietary vitamin C supplementation in a healthy population of 160 volunteers; supplementation was for a period of 15 weeks followed by a 10 week washout period. Peripheral blood samples were obtained every 5 weeks from baseline to 25 weeks. RESULTS:An increase in PBMC vitamin C levels was not observed following supplementation in healthy volunteers. There was no effect found on 8-oxoguanine measured using HPLC with electrochemical detection for any of the three supplemented groups compared to placebo. 8-oxoadenine levels were below the limit of detection of the HPLC system used here. CONCLUSIONS:Supplementation with vitamin C had little effect on cellular levels in this group of healthy individuals, suggesting their diets were replete in vitamin C. The dose range of vitamin C used did not affect oxidative damage in PBMC DNA.

journal_name

Eur J Nutr

journal_title

European journal of nutrition

authors

Herbert KE,Fletcher S,Chauhan D,Ladapo A,Nirwan J,Munson S,Mistry P

doi

10.1007/s00394-005-0569-4

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

97-104

issue

2

eissn

1436-6207

issn

1436-6215

journal_volume

45

pub_type

杂志文章,随机对照试验

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