Abstract:
PURPOSE:Considerable variation in 25-hydroxyvitamin D (25(OH)D) in populations worldwide that seems to be independent of latitude has been reported. Therefore, we aimed to assess vitamin D status of a mid-aged German general population and to identify its dietary, lifestyle, anthropometric, and genetic determinants. METHODS:25(OH)D concentrations were measured by LC-MS/MS in plasma samples of a random subcohort of the German arm of the European Prospective Investigation into Cancer and Nutrition (EPIC) comprising 2,100 subjects aged 35-65 years. Associations between potential predictors and 25(OH)D were assessed by linear regression models. RESULTS:32.8% of the variance in 25(OH)D was explained by a multivariable regression model, with season being the by far strongest predictor (semi-partial R²: 14.6%). Sex, waist circumference, leisure time physical activity, smoking, polymorphisms in the GC, CYP2R1, and DHCR7 genes, supplement use, exogenous hormone use, alcohol consumption, egg consumption, and fish consumption were significantly associated with 25(OH)D concentrations as well. However, none of these factors explained >2.3% of the variance in 25(OH)D. CONCLUSION:Even with a comprehensive set of genetic, anthropometric, dietary, and lifestyle correlates, not more than 32.8% of the variation in 25(OH)D could be explained in the EPIC-Germany study, implying that vitamin D prediction scores may not provide an appropriate proxy for measured 25(OH)D. Food intake was only a weak predictor of 25(OH)D concentrations, while a strong seasonal fluctuation in 25(OH)D was shown.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Kühn T,Kaaks R,Teucher B,Hirche F,Dierkes J,Weikert C,Katzke V,Boeing H,Stangl GI,Buijsse Bdoi
10.1007/s00394-013-0577-8subject
Has Abstractpub_date
2014-04-01 00:00:00pages
731-41issue
3eissn
1436-6207issn
1436-6215journal_volume
53pub_type
杂志文章abstract:PURPOSE:Aim of this study was to identify a possible relationship among dietary fatty acids (FA) intake, FA adipose tissue (AT) profile and cancer condition in lean vs obese subjects affected or not by colorectal cancer (CRC). Actually, inadequate dietary habits together with physical inactivity are primary determinant...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02003-7
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Lutein is a carotenoid that may play a role in eye health. Human milk typically contains higher concentrations of lutein than infant formula. Preliminary data suggest there are differences in serum lutein concentrations between breastfed and formula-fed infants. AIM OF THE STUDY:To measure the serum lutein ...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-009-0047-5
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:Dietary polyphenols have been studied for their potential effects on metabolic disorders, but studies on risk of hypertension are scarce. This study aimed to test the association between total and individual classes of dietary polyphenols and incidence of hypertension in the Polish arm of the Health, Alcohol an...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1438-7
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). METHODS:We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,0...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02159-2
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:Impaired B vitamin status has been identified as a risk factor for major chronic diseases. This study aims at examining the determinants of plasma folate and vitamin B12 concentrations, considering lifestyle factors and MTHFR polymorphisms. METHODS:A total of 988 women aged 40-65 years from the French E3N coho...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1365-z
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:The relationship between 100% fruit juice (100%FJ) consumption and cardiovascular risk is object of debate: indeed, recently published investigations provided new but discrepant evidence on this important question and International dietary guidelines are not in agreement on recommendations about fruit juice con...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02426-7
更新日期:2020-11-04 00:00:00
abstract:PURPOSE:Uroguanylin (UGN) is a 16 amino acid peptide produced mainly by intestinal epithelial cells. Nutrients intake increases circulating levels of prouroguanylin that is processed and converted to UGN to activate the guanylyl cyclase 2C receptor (GUCY2C). Given that the UGN-GUCY2C system has been proposed as a novel...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0869-2
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Diet has an important role in host-microbiome interplay, which may result in intestinal permeability changes and physiopathological effects at a systemic level. Despite the importance of maternal microbiota as the main contributor to the initial microbial seeding, little is known about the effects of materna...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02337-7
更新日期:2020-07-29 00:00:00
abstract:PURPOSE:Walnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer. METHODS:COLO205 cells were pretreated with WPE and then stimulated with tu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1704-3
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mec...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1275-0
更新日期:2017-10-01 00:00:00
abstract::Carotenoids are important micronutrients in the human diet and are present in human serum at micromolar concentrations. In addition to their antioxidant potential, carotenoids obtain physiologically relevant properties such as influencing cellular signal pathways, gene expression or induction of detoxifying enzymes. I...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0475-1
更新日期:2004-12-01 00:00:00
abstract:PURPOSES:Hepatic lipid overloading induces lipotoxicity which can cause hepatocyte damage, fibrosis, and eventually progress to cirrhosis, which is associated with nonalcoholic fatty liver disease. Adiponectin receptors play important roles in regulating lipid metabolism. In this study, we used a lentivirus system to o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0594-7
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:A high intake of whole grains containing soluble fiber has been shown to lower glucose and insulin responses in overweight humans and humans with type 2 diabetes. AIM OF THE STUDY:We investigated the linearity of this response after consumption of 5 breakfast cereal test meals containing wheat and/or barley...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-009-0778-3
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The best nutritional option for newborn infants is mother's milk. However, some newborn babies may not be exclusively breastfed during the first months of life, potentially leading to reduced overall health status and the early onset of allergic diseases in some infants. Considerable research has been devote...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
doi:10.1007/s003940070024
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:High added sugar consumption has been associated with the development of metabolic syndrome (MetS). The American Heart Association (AHA) diet is designed to prevent and treat MetS; however, it remains unclear whether the AHA diet is effective on decreasing added sugar consumption. The aim of our study was to...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-017-1390-6
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Hepatic fatty acid synthesis is influenced by several nutritional and hormonal factors. In this study, we have investigated the effects of distinct experimental diets enriched in carbohydrate or in fat on hepatic lipogenesis. METHODS:Male Wistar rats were divided into four groups and fed distinct experimental ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0613-8
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Advanced glycation end products (AGEs) formed in food during high-heat cooking may induce overeating and inflammation. We investigated whether AGE contents in a single meal affect postprandial appetite and markers of inflammation, endothelial activation, and oxidative stress. METHODS:In total, 19 healthy overw...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-013-0574-y
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Coffee is known to contain phytochemicals with antioxidant potential. The aim of this study was to investigate possible antioxidant effects of coffee in healthy human volunteers. METHODS:A placebo-controlled intervention trial was carried out on 160 healthy human subjects, randomised into three groups, receivi...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-016-1336-4
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Advanced glycation endproducts (AGEs) are produced endogenously and also enter the body during the consumption of AGEs present in heat-processed food. It is unknown whether AGEs of dietary origin accumulate within the body of healthy individuals. AGEs can deposit within skin tissue long-term by crosslinking ext...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1495-y
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:These days, obesity threatens the health for which one of the main interventions is calorie restriction (CR). Due to the difficulty of compliance with this treatment, CR mimetics such as resveratrol (RSV) have been considered. The present study compared the effects of RSV and CR on hypothalamic remodeling in a ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1715-0
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Osteoporosis is associated with both lower health-related quality of life and depression in older people. We examined the independent and combined effects of a multi-component exercise program and calcium-vitamin D3 fortified milk on health-related quality of life (HR-QoL) and depression in older men. METHODS:...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-019-01969-8
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders. The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can i...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02382-2
更新日期:2020-09-10 00:00:00
abstract::Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases. Nutrition is likely the most important environmental factor that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-014-0654-7
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Although research suggests that antioxidant supplementation can protect against exercise-induced muscle damage and oxidative stress, also delayed post-exercise muscle recovery and hindered adaptation to training were reported in the supplemented athletes. PURPOSE:The purpose of the study was to evaluate the...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-014-0757-1
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:Compared to a healthy population, the gut microbiota in type 2 diabetes presents with several unfavourable features that may impair glucose regulation. The aim of this study was to evaluate the prebiotic effect of inulin-type fructans on the faecal microbiota and short-chain fatty acids (SCFA) in patients with ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02282-5
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:The prevention of Alzheimer's disease (AD) has become a real challenge due to its rising prevalence and the lack of an effective cure. Diet and nutrients have gained significant interest as potentially modifiable protective factors. PURPOSE:The aim of this review is to provide an updated summary of eviden...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-013-0561-3
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The primary role of polymorphonuclear neutrophils (PMNs) is to destroy pathogenic microorganisms after phagocytosis by producing reactive oxygen species (ROS) and toxic molecules. However, PMNs produce sufficient amounts of ROS during an oxidative burst to be autotoxic and detrimental to their own functions ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-004-0501-3
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:It is unclear if midlife consumption of dairy and soy food intake, and their components of calcium and isoflavones (in soy), is related to cognitive impairment in elderly. METHODS:We used baseline data on lifestyle and habitual diet of 16,948 participants collected during their recruitment into the Singapore C...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02010-8
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Both hempseed oil (HO) and flaxseed oil (FO) contain high amounts of essential fatty acids (FAs); i.e. linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (ALA, 18:3n-3), but almost in opposite ratios. An excessive intake of one essential FA over the other may interfere with the metabolism of the other whil...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-006-0621-z
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose i...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1456-5
更新日期:2018-08-01 00:00:00