当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NUTRITION期刊下所有文献 > Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity.

Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity.

Abstract：

PURPOSE:Aim of this study was to identify a possible relationship among dietary fatty acids (FA) intake, FA adipose tissue (AT) profile and cancer condition in lean vs obese subjects affected or not by colorectal cancer (CRC). Actually, inadequate dietary habits together with physical inactivity are primary determinants of obesity and cancer risk. Changes in lipid metabolism play a crucial role in different types of cancer and key enzymes involved in lipid-metabolic pathways, such as stearoyl-coA-desaturase 1 (SCD-1), are differentially expressed in normal and cancer tissues. METHODS:Food frequency questionnaires (FFQ) were analyzed by Winfood software. FA were assessed by gas-liquid chromatography in visceral AT samples. Estimated desaturase activities were calculated as precursor FA/product FA ratio. Desaturase gene expressions were evaluated by RT-qPCR. RESULTS:Lean and obese CRC subjects showed inadequate dietary habits. In particular, lean CRC subjects showed increase in the intake of saturated FA, specifically palmitic (p = 0.0042) and stearic acid (p = 0.0091), and a corresponding reduction of monounsaturated FA consumption, in particular oleic acid (p = 0.002) with respect to lean without CRC. Estimated SCD-1 activity in AT was increased in all the groups vs lean without CRC (pANOVA = 0.029). CONCLUSIONS:Unhealthy eating habits, characterizing obese and CRC subjects, may influence the visceral AT profile and contribute to the alteration of the metabolic pathways. The quality of the diet, other than the quantity, can have a main role in the establishment of inflammatory microenvironment and in metabolic changes favouring CRC.

journal_name

Eur J Nutr

journal_title

European journal of nutrition

authors

Scazzocchio B,Varì R,Silenzi A,Giammarioli S,Masotti A,Baldassarre A,Santangelo C,D'Archivio M,Giovannini C,Del Cornò M,Conti L,Gessani S,Masella R

doi

10.1007/s00394-019-02003-7

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1463-1472

issue

4

eissn

1436-6207

issn

1436-6215

pii

10.1007/s00394-019-02003-7

journal_volume

59

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF NUTRITION文献大全
  • Low FODMAP diet significantly improves IBS symptoms: an Irish retrospective cohort study.

    abstract：INTRODUCTION:There is growing evidence that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) improves symptoms in irritable bowel syndrome (IBS) patients. We aimed to retrospectively investigate the effects of this diet in Irish IBS cohort over a 12-month follow-up period...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02074-6

    authors： Nawawi KNM,Belov M,Goulding C

    更新日期：2020-08-01 00:00:00

  • Diet-related inflammation and oesophageal cancer by histological type: a nationwide case-control study in Sweden.

    abstract：PURPOSE:This project sought to test the role of diet-related inflammation in modulating the risk of oesophageal cancer. METHODS:A nationwide population-based case-control study was conducted from 1 December 1994 through 31 December 1997 in Sweden. All newly diagnosed patients with adenocarcinoma of the oesophagus or g...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0987-x

    authors： Lu Y,Shivappa N,Lin Y,Lagergren J,Hébert JR

    更新日期：2016-06-01 00:00:00

  • Dietary fat differentially influences the lipids storage on the adipose tissue in metabolic syndrome patients.

    abstract：PURPOSE:Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Our aim was to investigate the effect of the dietary fat on the two main adipose tissue functions, endocrine and lipid store, by analyzing the adipose tissue gene expression from metabolic syndrome patients. METHODS:A randomized...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-013-0570-2

    authors： Camargo A,Meneses ME,Perez-Martinez P,Delgado-Lista J,Jimenez-Gomez Y,Cruz-Teno C,Tinahones FJ,Paniagua JA,Perez-Jimenez F,Roche HM,Malagon MM,Lopez-Miranda J

    更新日期：2014-01-01 00:00:00

  • N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis.

    abstract：PURPOSE:The objective of the present study was to test the hypothesis that N-acetylcysteine (NAC) may play beneficial roles against intrauterine growth retardation (IUGR)-induced hepatic damage in suckling piglets. METHODS:Fourteen IUGR and seven normal birth weight (NBW) neonatal male piglets were selected. Piglets w...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-016-1322-x

    authors： Zhang H,Su W,Ying Z,Chen Y,Zhou L,Li Y,Zhang J,Zhang L,Wang T

    更新日期：2018-02-01 00:00:00

  • Do European people with type 1 diabetes consume a high atherogenic diet? 7-year follow-up of the EURODIAB Prospective Complications Study.

    abstract：BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00394-012-0473-7

    authors： Soedamah-Muthu SS,Chaturvedi N,Fuller JH,Toeller M,EURODIAB Prospective Complications Study Group.

    更新日期：2013-10-01 00:00:00

  • Anthocyanins and phenolic acids from a wild blueberry (Vaccinium angustifolium) powder counteract lipid accumulation in THP-1-derived macrophages.

    abstract：PURPOSE:Blueberries are a rich source of anthocyanins (ACNs) and phenolic acids (PA), which are hypothesized to protect against development of atherosclerosis. The present study examined the effect of an ACN- and PA-rich fractions, obtained from a wild blueberry powder, on the capacity to counteract lipid accumulation ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0835-z

    authors： Del Bo' C,Cao Y,Roursgaard M,Riso P,Porrini M,Loft S,Møller P

    更新日期：2016-02-01 00:00:00

  • Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways.

    abstract：PURPOSE:This study was aimed to determine the impact of hydroxytyrosol (HT), a minor compound found in olive oil, on breast cancer stem cells (BCSCs) and the migration capacity of triple-negative breast cancer (TNBC) cell lines through the alteration of epithelial-to-mesenchymal transition (EMT) and embryonic signaling...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-018-1864-1

    authors： Cruz-Lozano M,González-González A,Marchal JA,Muñoz-Muela E,Molina MP,Cara FE,Brown AM,García-Rivas G,Hernández-Brenes C,Lorente JA,Sanchez-Rovira P,Chang JC,Granados-Principal S

    更新日期：2019-12-01 00:00:00

  • The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome.

    abstract：BACKGROUND:Nut consumption is associated with a protective effect against coronary heart disease, partly due to its high antioxidant content. It is hypothesized that the inclusion of nuts in the diet will improve the antioxidant status of subjects with metabolic syndrome who may be vulnerable to impaired antioxidant st...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-007-0647-x

    authors： Davis L,Stonehouse W,Loots du T,Mukuddem-Petersen J,van der Westhuizen FH,Hanekom SM,Jerling JC

    更新日期：2007-04-01 00:00:00

  • Fish consumption, intake of fats and cognitive decline at middle and older age: the Doetinchem Cohort Study.

    abstract：PURPOSE:To get insight in the impact of fish and fat intake in the prevention of accelerated cognitive decline with ageing, we tested associations between fish and different fat intakes and 5-year change in cognitive functions. METHODS:In 2612 men and women of the Doetinchem Cohort Study, aged 43-70 years at baseline,...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-017-1453-8

    authors： Nooyens ACJ,van Gelder BM,Bueno-de-Mesquita HB,van Boxtel MPJ,Verschuren WMM

    更新日期：2018-06-01 00:00:00

  • Disparate metabolic effects of blackcurrant seed oil in rats fed a basal and obesogenic diet.

    abstract：PURPOSE:It was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine. METHODS:Male Wistar rats were randomly assigned to four groups o...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-014-0775-z

    authors： Jurgoński A,Fotschki B,Juśkiewicz J

    更新日期：2015-09-01 00:00:00

  • Drinking patterns are associated with variations in atherosclerotic risk factors in French men.

    abstract：BACKGROUND:While a relationship between alcohol and cardiovascular risk factors is well established, data suggest that the type of alcoholic beverage could modulate this relationship. AIM OF THE STUDY:To determine whether drinking patterns modulate the relationship between alcohol and cardiovascular risk factors. MET...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-005-0567-6

    authors： Rouillier P,Bertrais S,Daudin JJ,Bacro JN,Hercberg S,Boutron-Ruault MC

    更新日期：2006-03-01 00:00:00

  • FUT2-dependent breast milk oligosaccharides and allergy at 2 and 5 years of age in infants with high hereditary allergy risk.

    abstract：PURPOSE:Manifestation of allergic disease depends on genetic predisposition, diet and commensal microbiota. Genetic polymorphism of mothers determines their breast milk glycan composition. One major determinant is the fucosyltransferase 2 (FUT2, secretor gene) that was shown to be linked to commensal microbiota establi...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-016-1180-6

    authors： Sprenger N,Odenwald H,Kukkonen AK,Kuitunen M,Savilahti E,Kunz C

    更新日期：2017-04-01 00:00:00

  • Acute supplementation with grapes in obese subjects did not affect postprandial metabolism: a randomized, double-blind, crossover clinical trial.

    abstract：PURPOSE:The aim of this study was to determine whether grape polyphenols have a "second-meal effect", modulating glucose and lipid elevations in the postprandial period after two successive meals in subjects with obesity. METHODS:A randomized, double-blind, placebo-controlled, acute clinical trial was conducted. Twent...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-020-02451-6

    authors： García-Díez E,Cuesta-Hervás M,Veses-Alcobendas AM,Alonso-Gordo Ó,García-Maldonado E,Martínez-Suárez M,Herranz B,Vaquero MP,Álvarez MD,Pérez-Jiménez J

    更新日期：2021-01-02 00:00:00

  • Vitamin D deficiency and hyperparathyroidism in relation to ethnicity: a cross-sectional survey in healthy adults.

    abstract：BACKGROUND:The study of vitamin D status at population level gained relevance since vitamin D deficiency was recently suggested to trigger chronic disease. AIM OF THE STUDY:We aimed to describe vitamin D status, its association with bone and mineral metabolism and risk factors for deficiency in adults over 40 years in...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-008-0756-1

    authors： Moreno-Reyes R,Carpentier YA,Boelaert M,El Moumni K,Dufourny G,Bazelmans C,Levêque A,Gervy C,Goldman S

    更新日期：2009-02-01 00:00:00

  • The urinary phenolic acid profile varies between younger and older adults after a polyphenol-rich meal despite limited differences in in vitro colonic catabolism.

    abstract：PURPOSE:To investigate whether age influences colonic polyphenol metabolism. METHODS:Healthy participants, younger (n = 8; 23-43 years) and older (n = 13; 51-76 years), followed a 3-day low-polyphenol diet (LPD) and a 3-day high-polyphenol diet (HPD). Urinary phenolic acids (PA), short chain fatty acids (SCFA), pH and...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-018-1625-1

    authors： Alkhaldy A,Edwards CA,Combet E

    更新日期：2019-04-01 00:00:00

  • Fruit and vegetable intake and pre-diabetes: a case-control study.

    abstract：PURPOSE:Few studies have evaluated the association of fruit and vegetable (FV) intake and pre-diabetes. However, these studies are very limited and incomplete. Therefore, the aim of our study was to compare FV consumption and their subgroups between pre-diabetic and control subjects. METHODS:This case-control study in...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-017-1569-x

    authors： Safabakhsh M,Koohdani F,Bagheri F,Siassi F,Khajehnasiri F,Sotoudeh G

    更新日期：2018-12-01 00:00:00

  • Ultra-processed food consumption patterns among older adults in the Netherlands and the role of the food environment.

    abstract：PURPOSE:To describe the patterns of ultra-processed foods (UPFs) consumption in the Netherlands; to test if exposure to the food environment is associated with UPFs consumption; and if this association differed across educational levels and neighbourhood urbanisation. METHODS:Cross-sectional study using 2015-data of 8...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-020-02436-5

    authors： Pinho MGM,Lakerveld J,Harbers MC,Sluijs I,Vermeulen R,Huss A,Boer JMA,Verschuren WMM,Brug J,Beulens JWJ,Mackenbach JD

    更新日期：2020-11-24 00:00:00

  • Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects.

    abstract：BACKGOUND:Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE:To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postpr...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-018-1612-6

    authors： Smolders L,Mensink RP,van den Driessche JJ,Joris PJ,Plat J

    更新日期：2019-04-01 00:00:00

  • Meal replacement based on Human Ration modulates metabolic risk factors during body weight loss: a randomized controlled trial.

    abstract：PURPOSE:A meal replacement may be an effective strategy in the management of obesity to increase antioxidant intake, attenuating oxidative stress and inflammation. In the present study, we investigated the efficacy of a new nutritional supplement to reduce metabolic risk parameters in obese women. METHODS:In a randomi...

    journal_title：European journal of nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00394-013-0598-3

    authors： Alves NE,Enes BN,Martino HS,Alfenas Rde C,Ribeiro SM

    更新日期：2014-04-01 00:00:00

  • Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study.

    abstract：BACKGROUND:The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02087-1

    authors： Cano-Ibáñez N,Bueno-Cavanillas A,Martínez-González MÁ,Salas-Salvadó J,Corella D,Freixer GL,Romaguera D,Vioque J,Alonso-Gómez ÁM,Wärnberg J,Martínez JA,Serra-Majem L,Estruch R,Tinahones FJ,Lapetra J,Pintó X,Tur JA,García

    更新日期：2020-09-01 00:00:00

  • Complementary food with low (8%) or high (12%) meat content as source of dietary iron: a double-blinded randomized controlled trial.

    abstract：BACKGROUND:To investigate whether a low meat content of complementary food as accepted by EU law increases the risk of well-nourished infants to develop iron deficiency during the complementary feeding period. METHODS:Term born, healthy infants were randomized into a 'High Meat' Group (HM, n = 48) receiving commercial...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-009-0043-9

    authors： Dube K,Schwartz J,Mueller MJ,Kalhoff H,Kersting M

    更新日期：2010-02-01 00:00:00

  • Short-chain fructooligosaccharides, in spite of being fermented in the upper part of the large intestine, have anti-inflammatory activity in the TNBS model of colitis.

    abstract：:Previous studies have demonstrated the anti-inflammatory effect of fructooligosaccharides (FOS) on intestinal inflammation. The aim of the present study was to elucidate whether the colonic fermentation of these carbohydrates is a pre-requisite for this anti-inflammatory activity.With this aim short chain-FOS (SC-FOS)...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-006-0610-2

    authors： Lara-Villoslada F,de Haro O,Camuesco D,Comalada M,Velasco J,Zarzuelo A,Xaus J,Galvez J

    更新日期：2006-10-01 00:00:00

  • Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells.

    abstract：PURPOSE:Pomegranate fruit, Punica granatum L. (Punicaceae), and its constituents have been shown to inhibit inflammation. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. METHODS:An enzyme immunoassay (EIA) was used to measure prostag...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0984-0

    authors： Velagapudi R,Baco G,Khela S,Okorji U,Olajide O

    更新日期：2016-06-01 00:00:00

  • Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice.

    abstract：PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Bet...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-020-02362-6

    authors： Chen W,Zhang X,Xu M,Jiang L,Zhou M,Liu W,Chen Z,Wang Y,Zou Q,Wang L

    更新日期：2020-08-17 00:00:00

  • Acceptability and efficacy of ready-to-use therapeutic food using soy protein isolate in under-5 children suffering from severe acute malnutrition in Bangladesh: a double-blind randomized non-inferiority trial.

    abstract：BACKGROUND AND OBJECTIVE:Globally, around 20 million children suffer from severe acute malnutrition (SAM). Identifying a more economical treatment for those affected has the potential to make treatment more available and improve prognosis for recovery and future health. DESIGN/METHODS:The double-blind randomized study...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-019-01975-w

    authors： Hossain MI,Huq S,Islam MM,Ahmed T

    更新日期：2020-04-01 00:00:00

  • Micronutrient status and intake in omnivores, vegetarians and vegans in Switzerland.

    abstract：PURPOSE:Vegetarian and vegan diets have gained popularity in Switzerland. The nutritional status of individuals who have adopted such diets, however, has not been investigated. The aim of this study was to assess the intake and status of selected vitamins and minerals among vegetarian and vegan adults living in Switzer...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-1079-7

    authors： Schüpbach R,Wegmüller R,Berguerand C,Bui M,Herter-Aeberli I

    更新日期：2017-02-01 00:00:00

  • In vitro activity of dietary flavonol congeners against human cancer cell lines.

    abstract：BACKGROUND:Flavonoids have physiological activity and a variety of pharmacological properties, including anticancer activity in vitro, but structure-anticancer activity relationships are unclear. AIM:The objectives of this work were to investigate the activity of dietary flavonol congeners against cell lines derived f...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-011-0204-5

    authors： Tsimplouli C,Demetzos C,Hadzopoulou-Cladaras M,Pantazis P,Dimas K

    更新日期：2012-03-01 00:00:00

  • Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice.

    abstract：PURPOSE:Although several researches have demonstrated that rooibos extract has hypoglycemic effect, the role of aspalathin, a main polyphenol in the extract, remains unclear. Our aims were to find specific mechanisms for anti-diabetic action of aspalathin employing a rat skeletal muscle-derived cell line (L6 myocytes) ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-012-0466-6

    authors： Son MJ,Minakawa M,Miura Y,Yagasaki K

    更新日期：2013-09-01 00:00:00

  • Vegetarian diets in children: a systematic review.

    abstract：PURPOSE:While the prevalence of children on vegetarian diets is assumed to be on the rise in industrialized countries, there are hardly any representative data available. In general, vegetarian diets are presumed to be healthy; nevertheless, there are concerns as to whether the dietary specifications required during in...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,评审

    doi：10.1007/s00394-017-1416-0

    authors： Schürmann S,Kersting M,Alexy U

    更新日期：2017-08-01 00:00:00

  • Maternal diet, bioactive molecules, and exercising as reprogramming tools of metabolic programming.

    abstract：:Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases. Nutrition is likely the most important environmental factor that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,评审

    doi：10.1007/s00394-014-0654-7

    authors： Mathias PC,Elmhiri G,de Oliveira JC,Delayre-Orthez C,Barella LF,Tófolo LP,Fabricio GS,Chango A,Abdennebi-Najar L

    更新日期：2014-04-01 00:00:00