Abstract：
PURPOSE:The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). METHODS:We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes. RESULTS:During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women. CONCLUSIONS:We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Bork CS,Lasota AN,Lundbye-Christensen S,Jakobsen MU,Tjønneland A,Overvad K,Schmidt EBdoi
10.1007/s00394-019-02159-2subject
Has Abstractpub_date
2020-10-01 00:00:00pages
3191-3200issue
7eissn
1436-6207issn
1436-6215pii
10.1007/s00394-019-02159-2journal_volume
59pub_type
杂志文章abstract：PURPOSE:Walnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer. METHODS:COLO205 cells were pretreated with WPE and then stimulated with tu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1704-3
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. AIM OF THE STUDY:To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel t...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-003-0421-7
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:The secoiridoid oleuropein, as found in olives and olive leaves, modulates some biomarkers of diabetes risk in vivo. A possible mechanism may be to attenuate sugar digestion and absorption. METHODS:We explored the potential of oleuropein, prepared from olive leaves in a water soluble form (OLE), to inhibit dig...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-018-1662-9
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:Results from epidemiologic studies on coffee consumption and the risk of cutaneous melanoma are inconsistent. We conducted a meta-analysis to assess the associations between the consumption of total coffee, caffeinated coffee and decaffeinated coffee and the risk of cutaneous melanoma, respectively. METHODS:A ...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00394-015-1139-z
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:Several studies in recent years have investigated the relationship between alcohol intake and melanoma risk, with conflicting results. To help clarify this issue, we conducted a literature review and dose-response meta-analysis of studies published until June 30th, 2017, that examined the association between al...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析
doi：10.1007/s00394-018-1613-5
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Although research suggests that antioxidant supplementation can protect against exercise-induced muscle damage and oxidative stress, also delayed post-exercise muscle recovery and hindered adaptation to training were reported in the supplemented athletes. PURPOSE:The purpose of the study was to evaluate the...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-014-0757-1
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:The only effective and safe treatment of celiac disease (CD) continues being strict exclusion of gluten for life, the so-called gluten-free diet (GFD). Although this treatment is highly successful, following strict GFD poses difficulties to patients in family, social and working contexts, deteriorating his/her ...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-016-1238-5
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Glutathione peroxidase 1 (GPx1) is an antioxidant selenoenzyme that protects the cells against reactive oxygen species. Its activity depends on the concentration of selenium (Se) which is present in the active centre of the enzyme. The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the pro...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-009-0023-0
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Both hempseed oil (HO) and flaxseed oil (FO) contain high amounts of essential fatty acids (FAs); i.e. linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (ALA, 18:3n-3), but almost in opposite ratios. An excessive intake of one essential FA over the other may interfere with the metabolism of the other whil...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-006-0621-z
更新日期：2006-12-01 00:00:00
abstract：INTRODUCTION:The prevention of Alzheimer's disease (AD) has become a real challenge due to its rising prevalence and the lack of an effective cure. Diet and nutrients have gained significant interest as potentially modifiable protective factors. PURPOSE:The aim of this review is to provide an updated summary of eviden...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-013-0561-3
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:The potential association between endometriosis and coffee/caffeine consumption has been analysed in several epidemiological studies. In order to establish whether caffeine influences the risk of endometriosis, we provide to summarize the evidence from published studies on this issue. METHODS:We performed a me...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析
doi：10.1007/s00394-014-0662-7
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:We examined associations between substitution of red meat (total, processed and unprocessed, low fat and high fat) with poultry or fish and substitution of processed red meat with unprocessed red meat and the risk of type 2 diabetes. METHODS:A cohort of 53,163 participants from the Danish Diet, Cancer and Heal...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1820-0
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:Compared to a healthy population, the gut microbiota in type 2 diabetes presents with several unfavourable features that may impair glucose regulation. The aim of this study was to evaluate the prebiotic effect of inulin-type fructans on the faecal microbiota and short-chain fatty acids (SCFA) in patients with ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02282-5
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Tryptophan is an essential amino acid, precursor of serotonin. Serotonin (5HT) regulates the secretion of pituitary growth hormone (GH), which in turn stimulates the liver to produce insulin-like growth factor-I (IGF-I) that is necessary for development and growth. The aim of our study was to investigate the ef...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0528-4
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND AND AIM:Breast cancer remains a leading cause of mortality among women. In metastasis, cascade migration of cancer cells and invasion of extracellular matrix (ECM) represent critical steps. Urokinase-type plasminogen activator (uPA), as well as metalloproteinases MMP-2 and MMP-9, strongly contribute to ECM r...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0542-6
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Due to their lower glycaemic index, leguminous seeds affect human carbohydrate metabolism lesser than do cereals. Problems, however, could arise from side effects, e.g., increasing flatulence. AIM OF THE STUDY AND METHODS:In 26 healthy subjects, metabolic and symptomatic responses following acute ingestion ...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s003940050060
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02087-1
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Bet...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02362-6
更新日期：2020-08-17 00:00:00
abstract：PURPOSE:Previously, anthocyanin-rich blueberry treatments have shown positive effects on cognition in both animals and human adults. However, little research has considered whether these benefits transfer to children. Here we describe an acute time-course and dose-response investigation considering whether these cognit...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-015-1029-4
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:The contribution of extra virgin olive oil (EVOO) macro- and micro-constituents in heart oxidative and inflammatory status in a hypercholesterolemic rat model was evaluated. Fatty acid profile as well as α-tocopherol, sterol, and squalene content was identified directly in rat hearts to distinguish the effect o...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0947-5
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:Reports on the protective effect of a Mediterranean diet on mortality usually refer to populations from Mediterranean countries, leaving uncertain whether really diet is the fundamental cause. Our aim was to examine the effect of a Mediterranean diet on mortality in Switzerland, a country combining cultural inf...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0695-y
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02395-x
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Although several observational studies have consistently reported an inverse association between moderate alcohol consumption and risk of coronary heart disease (CHD), it is yet not well established if this association also exists among people with type 2 diabetes. The aim of this study is to evaluate the as...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-009-0065-3
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To assess the effect of medium-chain fatty acid (MCFA)-rich mustard oil and polyunsaturated fatty acid (PUFA)-rich mustard oil on erythrocyte membrane composition and osmotic fragility in normal and hypercholesterolemic rats. METHOD:Membrane composition was analyzed using standard kits. Osmotic fragility was d...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-010-0150-7
更新日期：2011-09-01 00:00:00
abstract：PURPOSE:Several epidemiological studies have demonstrated the health benefits of polyphenols, but the associations between polyphenol intake and mortality including total and major causes of death remain unclear. We investigated the associations between subjects' total polyphenol intake and their mortality from all cau...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02136-9
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:While a relationship between alcohol and cardiovascular risk factors is well established, data suggest that the type of alcoholic beverage could modulate this relationship. AIM OF THE STUDY:To determine whether drinking patterns modulate the relationship between alcohol and cardiovascular risk factors. MET...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-005-0567-6
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:Recent epidemiological studies have shown that habitual consumption of extra virgin olive oil (EVOO), the characteristic culinary fat of the Mediterranean area, is effective in the prevention of diverse types of digestive disorders such as inflammatory bowel disease. Many of these benefits are, in addition to i...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0235-y
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:A meal replacement may be an effective strategy in the management of obesity to increase antioxidant intake, attenuating oxidative stress and inflammation. In the present study, we investigated the efficacy of a new nutritional supplement to reduce metabolic risk parameters in obese women. METHODS:In a randomi...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-013-0598-3
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:To compare the glycaemic response of whole grain oat kernels and pearled oats cooked under normal pressure or higher pressure and examine whether replacing half of the rice in a given meal with either of the two oat grains could make a difference in acute glycaemic responses. METHODS:In a randomised crossover ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02083-5
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1793-z
更新日期：2019-09-01 00:00:00
