Abstract:
:The potential impact on health of diets rich in free sugars, and particularly fructose, is of major concern. The focus of this review is the impact of these sugars on insulin resistance and obesity, and the associated risk of developing type 2 diabetes. Much of the concern is focussed on specific metabolic effects of fructose, which are argued to lead to increased fat deposition in the liver and skeletal muscle with subsequent insulin resistance and increased risk of diabetes. However, much of the evidence underpinning these arguments is based on animal studies involving very large intakes of the free sugars. Recent human studies, in the past 5 years, provide a rather different picture, with a clear dose response link between fructose intake and metabolic changes. In particular, the most marked effects are observed when a high sugars intake is accompanied by an excess energy intake. This does not mean that a high intake of free sugars does not have any detrimental impact on health, but rather that such an effect seems more likely to be a result of the high sugars intake increasing the chances of an excessive energy intake rather than it leading to a direct detrimental effect on metabolism.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Macdonald IAdoi
10.1007/s00394-016-1340-8subject
Has Abstractpub_date
2016-11-01 00:00:00pages
17-23issue
Suppl 2eissn
1436-6207issn
1436-6215pii
10.1007/s00394-016-1340-8journal_volume
55pub_type
杂志文章,评审abstract::Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases. Nutrition is likely the most important environmental factor that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-014-0654-7
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula. METHODS:A nested case-control study was ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1668-3
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:High added sugar consumption has been associated with the development of metabolic syndrome (MetS). The American Heart Association (AHA) diet is designed to prevent and treat MetS; however, it remains unclear whether the AHA diet is effective on decreasing added sugar consumption. The aim of our study was to...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-017-1390-6
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION:Breast cancer prevalence is growing worldwide. Many factors, such as diet and lifestyle could be determinants of the incidence of breast cancer. Coffee has been extensively studied in relation to several chronic diseases because of its multiple effects in health maintenance and its elevated consumption. We...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02180-w
更新日期:2020-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-012-0461-y
更新日期:2013-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-013-0574-y
更新日期:2014-01-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-007-0691-6
更新日期:2008-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1251-8
更新日期:2017-09-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-017-1529-5
更新日期:2018-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-013-0508-8
更新日期:2014-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1628-y
更新日期:2019-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-012-0331-7
更新日期:2012-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1237-6
更新日期:2017-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1152-x
更新日期:2017-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-008-0764-1
更新日期:2009-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0842-0
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer's disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. METHODS:We used summary statistics data for single-nucleotide polymorphisms associated with plasm...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02126-x
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To estimate total sodium (Na) and potassium (K) intake using non-fasting morning urine specimens among Lebanese elementary (6-10 year old) schoolchildren. METHOD:A national cross-sectional study was conducted. A multistage cluster sampling procedure was used to select a representative sample of 1403 healthy ch...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1164-6
更新日期:2017-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0542-6
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Anemia and vitamin D deficiency are both frequent in adult patients. Whether low vitamin D metabolite levels are an independent risk factor for different subtypes of anemia remains to be studied in detail. METHODS:In 3299 patients referred for coronary angiography, we investigated the association of 25-hydroxy...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1149-x
更新日期:2017-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0452-z
更新日期:2013-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1225-x
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Bet...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02362-6
更新日期:2020-08-17 00:00:00
abstract:PURPOSE:The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-016-1376-9
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Antioxidant defence has been reported to decrease, and oxidative stress to increase, after oral glucose loading in both normal and diabetic subjects. If confirmed in normal subjects, glucose-induced antioxidant depletion has important implications for health in relation to the modern, sugar-rich diet. AIM O...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-004-0518-7
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:Fruit and vegetable (FV) consumption and salt intake are known dietary influences on blood pressure (BP) in adults, but data on their long-term relevance during growth for later BP are rare. We aimed to examine the independent and concomitant influences of adolescent FV and salt intakes on BP in young adulthood...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0804-y
更新日期:2015-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1752-8
更新日期:2019-08-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1883-y
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Fish and fish oils are rich in the two long-chain polyunsaturated fatty acids (LCPUFAs) eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). The n-3 LCPUFAs have been reported to have beneficial effects on cardiovascular functions, but their role in relation to immune functions is st...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s003940170016
更新日期:2001-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-0939-5
更新日期:2015-12-01 00:00:00