Abstract：
BACKGROUND:Intraduodenal administration of peptone prepared from soybean beta-conglycinin (BconP) stimulates cholecystokinin (CCK) secretion from enteroendocrine cells, and suppresses food intake in rats. However, the sensing mechanism of BconP by CCK-producing cells is unknown. AIM OF THE STUDY:We investigated signal transduction pathways mediating CCK secretion in response to BconP in the murine CCK-producing cell line, STC-1. METHODS:STC-1 cells were seeded in 48-well culture plates until sub-confluent and CCK secretion was examined under various conditions. CCK concentration was determined by the enzyme immunoassay. RESULTS:BconP dose-dependently induced CCK secretion in STC-1 cells. Treatment with BAPTA-AM, an intracellular Ca2+ chelator, reduced BconP-induced CCK secretion, however, removal of extracellular Ca2+ did not affect the secretory response. Treatment with 2-amino borate (2-APB) reduced CCK releasing responses, suggesting the involvement of IP(3). In addition, BconP failed to induce CCK secretion after treatment with the Galphaq protein inhibitor (YM-254890). CONCLUSION:These results indicate that Galphaq pathway is responsible for BconP-induced CCK secretion in STC-1 cells, and suggest the involvement of a Galphaq-coupled GPCR(s) in dietary peptide sensing in enteroendocrine cells.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Hira T,Maekawa T,Asano K,Hara Hdoi
10.1007/s00394-008-0764-1subject
Has Abstractpub_date
2009-03-01 00:00:00pages
124-7issue
2eissn
1436-6207issn
1436-6215journal_volume
48pub_type
杂志文章abstract：PURPOSE:This study aimed to assess the dietary patterns of adolescents using a food-based diet quality index and their compliance with a healthy dietary guideline METHODS: Participants included 71,553 Brazilian adolescents (12-17 years old) from the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectiona...
journal_title：European journal of nutrition
pub_type： 杂志文章,多中心研究
doi：10.1007/s00394-019-01923-8
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abstract：BACKGROUND:Inulin-type fructans or chains with mainly beta[2-1] linked fructose molecules escape the ingestion procedure in the small intestine and are fermented by the microflora, and are known to increase colonic absorption of minerals in animals. The fermentation rate in the large bowel into short-chain fatty acids ...
journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章,多中心研究
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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更新日期：2018-04-01 00:00:00
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journal_title：European journal of nutrition
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更新日期：2009-09-01 00:00:00
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-02-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-003-0398-2
更新日期：2003-01-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1385-3
更新日期：2018-04-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：European journal of nutrition
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doi：10.1007/s00394-015-0906-1
更新日期：2016-04-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2007-03-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2017-03-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02003-7
更新日期：2020-06-01 00:00:00
