Abstract:
PURPOSE:Critically low skeletal muscle mass and strength, observed in 20% of people with chronic heart failure (CHF), reduces functional capacity, quality of life (QoL) and survival. Protein and essential amino acid (EAA) supplementation could be a viable treatment strategy to prevent declines in muscle strength and performance, and subsequently improve QoL and survival. This systematic review (PROSPERO: CRD42018103649) aimed to assess the effect of dietary protein and/or EAA supplementation on muscle strength and performance in people with CHF. METHODS:Searches of PubMed, MEDLINE and Embase identified studies that reported changes in strength or muscle performance following protein and/or EAA supplementation in patients with CHF. Following PRISMA guidelines and using predefined inclusion/exclusion criteria relating to participants, intervention, control, outcome and study design, two reviewers independently screened titles, abstracts and full manuscripts for eligibility. Risk of bias was assessed using Cochrane Risk of Bias Tool (RCTs) or Mixed Methods Appraisal Tool (cohort studies). Data were extracted for analysis using predefined criteria. RESULTS:Five randomised controlled trials (RCT) and one cohort study met our inclusion criteria. All RCTs had a high risk of bias. The methodological quality of the cohort study was moderate. Heterogeneity of extracted data prevented meta-analyses, qualitative synthesis was therefore performed. Data from 167 patients with CHF suggest that protein and/or EAA supplementation does not improve strength, but may increase six-minute walk test distance, muscle mass and QoL. CONCLUSIONS:The limited quality of the studies makes firm conclusions difficult, however protein and/or EAA supplementation may improve important outcome measures related to sarcopenia. High-quality randomised controlled studies are needed.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Nichols S,McGregor G,Al-Mohammad A,Ali AN,Tew G,O'Doherty AFdoi
10.1007/s00394-019-02108-zsubject
Has Abstractpub_date
2020-08-01 00:00:00pages
1785-1801issue
5eissn
1436-6207issn
1436-6215pii
10.1007/s00394-019-02108-zjournal_volume
59pub_type
杂志文章,评审abstract:PURPOSE:To investigate the longitudinal association between the macronutrient composition of the diet and frailty. METHODS:Data were obtained from 5205 Dutch middle-aged and older adults participating in the Rotterdam Study. Frailty was measured using a frailty index based on the accumulation of 38 health-related defi...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02131-0
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:Pomegranate fruit, Punica granatum L. (Punicaceae), and its constituents have been shown to inhibit inflammation. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. METHODS:An enzyme immunoassay (EIA) was used to measure prostag...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0984-0
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:While the prevalence of children on vegetarian diets is assumed to be on the rise in industrialized countries, there are hardly any representative data available. In general, vegetarian diets are presumed to be healthy; nevertheless, there are concerns as to whether the dietary specifications required during in...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-017-1416-0
更新日期:2017-08-01 00:00:00
abstract:PURPOSES:Hepatic lipid overloading induces lipotoxicity which can cause hepatocyte damage, fibrosis, and eventually progress to cirrhosis, which is associated with nonalcoholic fatty liver disease. Adiponectin receptors play important roles in regulating lipid metabolism. In this study, we used a lentivirus system to o...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0594-7
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Enhanced tryptophan degradation via the kynurenine pathway has been related to several pathological conditions. However, little is known about the effect of diet on individual metabolites of this pathway. We investigated cross-sectional associations between reported intake of fish and omega-3 (n-3) long-chain P...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1077-9
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify metabolomic signatures re...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02177-5
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disorder. Probiotics and synbiotics have been shown to improve symptoms of IBS, although mechanisms of action are currently not understood. METHODS:We investigated the effects of a 4-week oral synbiotic treatment (OMN...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1826-7
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Dietary polyphenols have been reported to have a variety of biological actions, including anticarcinogenic and antioxidant activities. AIM OF THE STUDY:In the present study we investigated the protective effect of dietary polyphenols against N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR) and ben...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-008-0751-6
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:Nicotinic acid is one of the older drugs used to treat hyperlipidemia, the greatest risk factor of coronary heart disease. Nicotinic acid is also a precursor of the coenzyme nicotinamide adenine dinucleotide (NAD). In mammals, α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) plays a key role in NA...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0547-1
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Phenolic acids are important phenolic compounds widespread in foods, contributing to nutritional and organoleptic properties. FACTORS AFFCETING INDIVIDUAL VARIABILITY:The bioavailability of these compounds depends on their free or conjugated presence in food matrices, which is also affected by food proces...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-019-01987-6
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Green tea is thought to possess many beneficial effects on human health. However, the extent of green tea polyphenol biotransformation may affect its proposed therapeutic effects. Catechol-O-methyltransferase (COMT), the enzyme responsible for polyphenolic methylation, has a common polymorphism in the genetic c...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
doi:10.1007/s00394-011-0189-0
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mec...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1275-0
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:Atherosclerosis is known to be an inflammatory disease. Dendritic cells (DCs) are essential for the regulation of the immune system. Up to 10% of the cells in atherosclerotic plaques are DCs. The cardiovascular protective effects of flavonoids (tea, wine) may be mediated by anti-inflammatory mechanisms that aff...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-010-0125-8
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily increase insulin secretio...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1644-y
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Manifestation of allergic disease depends on genetic predisposition, diet and commensal microbiota. Genetic polymorphism of mothers determines their breast milk glycan composition. One major determinant is the fucosyltransferase 2 (FUT2, secretor gene) that was shown to be linked to commensal microbiota establi...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-016-1180-6
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:Impaired B vitamin status has been identified as a risk factor for major chronic diseases. This study aims at examining the determinants of plasma folate and vitamin B12 concentrations, considering lifestyle factors and MTHFR polymorphisms. METHODS:A total of 988 women aged 40-65 years from the French E3N coho...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1365-z
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:It is thought that total energy intake in women is increased during the luteal versus follicular phase of the menstrual cycle; however, less is understood regarding changes in diet composition (i.e., macro- and micronutrient intakes) across the cycle. The aim of this study was to investigate changes in macronut...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0931-0
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Recent epidemiological studies have shown that habitual consumption of extra virgin olive oil (EVOO), the characteristic culinary fat of the Mediterranean area, is effective in the prevention of diverse types of digestive disorders such as inflammatory bowel disease. Many of these benefits are, in addition to i...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0235-y
更新日期:2012-06-01 00:00:00
abstract::The objective of this study was to assess the effect of conjugated linoleic acid isomers (CLAs) on the expression and activity of phospholipases A(2) (PLA(2)) in human macrophages. Macrophages were incubated with 30 microM cis-9, trans-11 and trans-10, cis-12 CLAs for 48 h. After incubation, the total activity of phos...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0626-7
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:The imbalance of n-6 and n-3 polyunsaturated fatty acids in the maternal diet impairs intestinal barrier development and sensitizes the colon response to inflammatory insults in the young rats. With a view to overcoming this issue, we designed this study to investigate the effect of maternal and neonatal int...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1004-0
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1793-z
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Amaranth is a crop that can be grown in different soils and climates, being resistant to high temperatures, drought, and some pests. The amaranth plant has nutritional qualities and desirable biological properties. AIM OF THE STUDY:The aim of the study is to investigate the potential antitumor properties of...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-009-0051-9
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Iodine fortification programs have been applied in many iodine deficient regions. Iodine excess is also unfavourable, and it is recommended to monitor iodine status by measuring urinary iodine concentration (UIC). The number of samples needed in such monitoring depends on the variation in UIC. However, it is...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0551-5
更新日期:2014-01-01 00:00:00
abstract::Low intracellular magnesium (Mg) contents may be observed in case of severe Mg insufficient intake or because of genetic regulation. This work was conducted to investigate the influence of intracellular Mg content on erythrocyte Mg(2+) influx and efflux in mice with low nutritionally and genetically (MGL and MGH mice)...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-005-0579-2
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Globally, around 20 million children suffer from severe acute malnutrition (SAM). Identifying a more economical treatment for those affected has the potential to make treatment more available and improve prognosis for recovery and future health. DESIGN/METHODS:The double-blind randomized study...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-019-01975-w
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Mediterranean diet (MED) is associated with health benefits, yet scarce data exist regarding the role of MED in inflammatory bowel diseases (IBD). Herein, we aimed to evaluate the association between MED and inflammatory markers in patients with IBD after pouch surgery. METHODS:Consecutive patients after po...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02158-3
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:The potential association between endometriosis and coffee/caffeine consumption has been analysed in several epidemiological studies. In order to establish whether caffeine influences the risk of endometriosis, we provide to summarize the evidence from published studies on this issue. METHODS:We performed a me...
journal_title:European journal of nutrition
pub_type: 杂志文章,meta分析
doi:10.1007/s00394-014-0662-7
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid ...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-0982-2
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:The relationship between 100% fruit juice (100%FJ) consumption and cardiovascular risk is object of debate: indeed, recently published investigations provided new but discrepant evidence on this important question and International dietary guidelines are not in agreement on recommendations about fruit juice con...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02426-7
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:A recent prospective cohort study revealed that moderate wine consumption but not consumption of other alcoholic beverages is associated with a decreased risk of common cold. In contrast, wine constituents such as ethanol and polyphenols are known to suppress immunity. AIM OF THE STUDY:We investigated wheth...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-002-0384-0
更新日期:2002-12-01 00:00:00