Abstract：
PURPOSE:Indirect effects of a high-protein maternal diet are not well understood. In this study, we analyzed short-term and sustainable effects of a prenatal versus early postnatal maternal high-protein diet on growth and hepatic gene expression in mouse offspring. METHODS:Dams were exposed to an isoenergetic high-protein (HP, 40 % w/w) diet during pregnancy or lactation. Growth and hepatic expression profiles of male offspring were evaluated directly after weaning and 150 days after birth. Offspring from two dietary groups, high-protein diet during pregnancy and control diet during lactation (HPC), and control diet during pregnancy and high-protein diet during lactation (CHP), were compared with offspring (CC) from control-fed dams. RESULTS:Maternal CHP treatment was associated with sustained offspring growth retardation, but decreased numbers of affected hepatic genes in adults compared to weanlings. In contrast, offspring of the HPC group did not show persistent effects on growth parameters, but the number of affected hepatic genes was even increased at adult age. In both dietary groups, however, only a small subset of genes was affected in weanlings as well as in adults. CONCLUSIONS:We conclude that (1) prenatal and early postnatal maternal HP diet caused persistent, but (2) different effects and partially complementary trends on growth characteristics and on the hepatic transcriptome and associated pathways and that (3) only a small number of genes and associated upstream regulators might be involved in passing early diet-induced imprints to adulthood.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Vanselow J,Kucia M,Langhammer M,Koczan D,Metges CCdoi
10.1007/s00394-015-0906-1subject
Has Abstractpub_date
2016-04-01 00:00:00pages
917-30issue
3eissn
1436-6207issn
1436-6215pii
10.1007/s00394-015-0906-1journal_volume
55pub_type
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journal_title：European journal of nutrition
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pub_type： 临床试验,杂志文章,随机对照试验
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