Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells.

Abstract:

PURPOSE:Pomegranate fruit, Punica granatum L. (Punicaceae), and its constituents have been shown to inhibit inflammation. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. METHODS:An enzyme immunoassay (EIA) was used to measure prostaglandin E2 (PGE2) production from supernatants of IL-1β-stimulated SK-N-SH cells. Expression of COX-2, phospho-IκB, and phospho-IKK proteins was evaluated, while NF-κB reporter gene assay was carried out in TNFα-stimulated HEK293 cells to determine the effect of PWE on NF-κB transactivation. Levels of BACE-1 and Aβ in SK-N-SH cells stimulated with IL-1β were measured with an in cell ELISA. RESULTS:PWE (25-200 μg/ml) dose dependently reduced COX-2-dependent PGE2 production in SK-N-SH cells stimulated with IL-1β. Phosphorylation of IκB and IKK was significantly (p < 0.001) inhibited by PWE (50-200 μg/ml). Our studies also show that PWE (50-200 μg/ml) significantly (p < 0.01) inhibited NF-κB transactivation in TNFα-stimulated HEK293 cells. Furthermore, PWE inhibited BACE-1 and Aβ expression in SK-N-SH cells treated with IL-1β. CONCLUSIONS:Taken together, our study demonstrates that pomegranate inhibits inflammation, as well as amyloidogenesis in IL-1β-stimulated SK-N-SH cells. We propose that pomegranate is a potential nutritional strategy in slowing the progression of neurodegenerative disorders such as Alzheimer's disease.

journal_name

Eur J Nutr

authors

Velagapudi R,Baco G,Khela S,Okorji U,Olajide O

doi

10.1007/s00394-015-0984-0

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

1653-60

issue

4

eissn

1436-6207

issn

1436-6215

pii

10.1007/s00394-015-0984-0

journal_volume

55

pub_type

杂志文章
  • Anthocyanins and phenolic acids from a wild blueberry (Vaccinium angustifolium) powder counteract lipid accumulation in THP-1-derived macrophages.

    abstract:PURPOSE:Blueberries are a rich source of anthocyanins (ACNs) and phenolic acids (PA), which are hypothesized to protect against development of atherosclerosis. The present study examined the effect of an ACN- and PA-rich fractions, obtained from a wild blueberry powder, on the capacity to counteract lipid accumulation ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-015-0835-z

    authors: Del Bo' C,Cao Y,Roursgaard M,Riso P,Porrini M,Loft S,Møller P

    更新日期:2016-02-01 00:00:00

  • Inulin-enriched pasta affects lipid profile and Lp(a) concentrations in Italian young healthy male volunteers.

    abstract:BACKGROUND:Inulin has been suggested to have beneficial effects on lipids, especially on triglyceridemia. Few data are available about the effects of inulin on Lipoprotein(a), a low-density lipoprotein-like particle considered as an independent risk factor for atherosclerosis. Adding inulin to pasta could be a preventi...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-008-0748-1

    authors: Russo F,Chimienti G,Riezzo G,Pepe G,Petrosillo G,Chiloiro M,Marconi E

    更新日期:2008-12-01 00:00:00

  • The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study).

    abstract:PURPOSE:We examined whether high doses of folic acid and iron supplementation in early-to-mid pregnancy affect the risk of preterm birth, low birth weight, and small for gestational age neonates, in the mother-child cohort in Crete, Greece (Rhea study). METHODS:We included 1,279 women with singleton pregnancies with c...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-012-0339-z

    authors: Papadopoulou E,Stratakis N,Roumeliotaki T,Sarri K,Merlo DF,Kogevinas M,Chatzi L

    更新日期:2013-02-01 00:00:00

  • Impact of JNK1, JNK2, and ligase Itch on reactive oxygen species formation and survival of prostate cancer cells treated with diallyl trisulfide.

    abstract:PURPOSE:In our previous study, we demonstrated that diallyl trisulfide (DATS) induced iron-dependent G2-M arrest of prostate cancer cell cycle. Moreover, ferritin degradation and an increase of labile iron pool has been linked to the activation of the JNK signaling axis. In the present work, we extended this study to d...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-011-0241-0

    authors: Sielicka-Dudzin A,Borkowska A,Herman-Antosiewicz A,Wozniak M,Jozwik A,Fedeli D,Antosiewicz J

    更新日期:2012-08-01 00:00:00

  • Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions.

    abstract:PURPOSE:Ellagitannins are high molecular weight polyphenols present in high quantities in various food products. They are metabolized by human and animal gut microbiota to postbiotic metabolites-urolithins, bioavailable molecules of a low molecular weight. Following absorption in the gut, urolithins rapidly undergo pha...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-020-02386-y

    authors: Bobowska A,Granica S,Filipek A,Melzig MF,Moeslinger T,Zentek J,Kruk A,Piwowarski JP

    更新日期:2020-09-22 00:00:00

  • Dietary supplementation with different vitamin C doses: no effect on oxidative DNA damage in healthy people.

    abstract:BACKGROUND:Antioxidants are believed to prevent many types of disease. Some previous studies suggest that dietary supplementation with vitamin C results in a decrease in the level of one of the markers of oxidative damage-8-oxoguanine in the DNA of peripheral blood mononuclear cells (PBMC). AIM OF TRIAL: To investigate...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-005-0569-4

    authors: Herbert KE,Fletcher S,Chauhan D,Ladapo A,Nirwan J,Munson S,Mistry P

    更新日期:2006-03-01 00:00:00

  • Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study.

    abstract:BACKGROUND:The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-019-02087-1

    authors: Cano-Ibáñez N,Bueno-Cavanillas A,Martínez-González MÁ,Salas-Salvadó J,Corella D,Freixer GL,Romaguera D,Vioque J,Alonso-Gómez ÁM,Wärnberg J,Martínez JA,Serra-Majem L,Estruch R,Tinahones FJ,Lapetra J,Pintó X,Tur JA,García

    更新日期:2020-09-01 00:00:00

  • Association between habitual dietary and lifestyle behaviours and skin autofluorescence (SAF), a marker of tissue accumulation of advanced glycation endproducts (AGEs), in healthy adults.

    abstract:PURPOSE:Advanced glycation endproducts (AGEs) are produced endogenously and also enter the body during the consumption of AGEs present in heat-processed food. It is unknown whether AGEs of dietary origin accumulate within the body of healthy individuals. AGEs can deposit within skin tissue long-term by crosslinking ext...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-017-1495-y

    authors: Kellow NJ,Coughlan MT,Reid CM

    更新日期:2018-09-01 00:00:00

  • Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans.

    abstract:BACKGROUND:Glutathione peroxidase 1 (GPx1) is an antioxidant selenoenzyme that protects the cells against reactive oxygen species. Its activity depends on the concentration of selenium (Se) which is present in the active centre of the enzyme. The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the pro...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-009-0023-0

    authors: Jablonska E,Gromadzinska J,Reszka E,Wasowicz W,Sobala W,Szeszenia-Dabrowska N,Boffetta P

    更新日期:2009-09-01 00:00:00

  • The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety.

    abstract:BACKGROUND:Addition of capsaicin to the diet has been shown to increase satiety and thermogenesis. The effects of capsaicin on ghrelin, peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), in relation to changes in hunger and satiety are unknown. AIM:To test the acute effects of a lunch containing capsaicin on gut de...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-009-0006-1

    authors: Smeets AJ,Westerterp-Plantenga MS

    更新日期:2009-06-01 00:00:00

  • The physiology of colonic metabolism. Possibilities for interventions with pre- and probiotics.

    abstract::The awareness is increasing that in the colon many metabolic processes take place in relation to the fermentation of our food, which might be relevant for health and disease. However, the relation between food, colon metabolism and health or disease is far from clear. In this overview, the physiology of colonic metabo...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,评审

    doi:10.1007/s00394-002-1101-8

    authors: Priebe MG,Vonk RJ,Sun X,He T,Harmsen HJ,Welling GW

    更新日期:2002-11-01 00:00:00

  • Coffee and caffeine intake and risk of endometriosis: a meta-analysis.

    abstract:PURPOSE:The potential association between endometriosis and coffee/caffeine consumption has been analysed in several epidemiological studies. In order to establish whether caffeine influences the risk of endometriosis, we provide to summarize the evidence from published studies on this issue. METHODS:We performed a me...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00394-014-0662-7

    authors: Chiaffarino F,Bravi F,Cipriani S,Parazzini F,Ricci E,Viganò P,La Vecchia C

    更新日期:2014-10-01 00:00:00

  • Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors.

    abstract:BACKGROUND:Both hempseed oil (HO) and flaxseed oil (FO) contain high amounts of essential fatty acids (FAs); i.e. linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (ALA, 18:3n-3), but almost in opposite ratios. An excessive intake of one essential FA over the other may interfere with the metabolism of the other whil...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-006-0621-z

    authors: Schwab US,Callaway JC,Erkkilä AT,Gynther J,Uusitupa MI,Järvinen T

    更新日期:2006-12-01 00:00:00

  • Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways.

    abstract:PURPOSE:This study was aimed to determine the impact of hydroxytyrosol (HT), a minor compound found in olive oil, on breast cancer stem cells (BCSCs) and the migration capacity of triple-negative breast cancer (TNBC) cell lines through the alteration of epithelial-to-mesenchymal transition (EMT) and embryonic signaling...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-018-1864-1

    authors: Cruz-Lozano M,González-González A,Marchal JA,Muñoz-Muela E,Molina MP,Cara FE,Brown AM,García-Rivas G,Hernández-Brenes C,Lorente JA,Sanchez-Rovira P,Chang JC,Granados-Principal S

    更新日期:2019-12-01 00:00:00

  • Effect of AHA dietary counselling on added sugar intake among participants with metabolic syndrome.

    abstract:BACKGROUND:High added sugar consumption has been associated with the development of metabolic syndrome (MetS). The American Heart Association (AHA) diet is designed to prevent and treat MetS; however, it remains unclear whether the AHA diet is effective on decreasing added sugar consumption. The aim of our study was to...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-017-1390-6

    authors: Zhang L,Pagoto S,May C,Olendzki B,L Tucker K,Ruiz C,Cao Y,Ma Y

    更新日期:2018-04-01 00:00:00

  • Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women.

    abstract:INTRODUCTION:The objective of this paper was to evaluate the relationship between urinary concentrations of InsP6, bone mass loss and risk fracture in postmenopausal women. MATERIALS AND METHODS:A total of 157 postmenopausal women were included in the study: 70 had low (≤0.76 μM), 42 intermediate (0.76-1.42 μM) and 45...

    journal_title:European journal of nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00394-012-0377-6

    authors: López-González AA,Grases F,Monroy N,Marí B,Vicente-Herrero MT,Tur F,Perelló J

    更新日期:2013-03-01 00:00:00

  • Ultra-processed food consumption patterns among older adults in the Netherlands and the role of the food environment.

    abstract:PURPOSE:To describe the patterns of ultra-processed foods (UPFs) consumption in the Netherlands; to test if exposure to the food environment is associated with UPFs consumption; and if this association differed across educational levels and neighbourhood urbanisation. METHODS:Cross-sectional study using 2015-data of 8...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-020-02436-5

    authors: Pinho MGM,Lakerveld J,Harbers MC,Sluijs I,Vermeulen R,Huss A,Boer JMA,Verschuren WMM,Brug J,Beulens JWJ,Mackenbach JD

    更新日期:2020-11-24 00:00:00

  • Maternal and neonatal dietary intake of balanced n-6/n-3 fatty acids modulates experimental colitis in young adult rats.

    abstract:BACKGROUND:The imbalance of n-6 and n-3 polyunsaturated fatty acids in the maternal diet impairs intestinal barrier development and sensitizes the colon response to inflammatory insults in the young rats. With a view to overcoming this issue, we designed this study to investigate the effect of maternal and neonatal int...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-015-1004-0

    authors: Reddy KV,Naidu KA

    更新日期:2016-08-01 00:00:00

  • Coffee consumption and the risk of cutaneous melanoma: a meta-analysis.

    abstract:PURPOSE:Results from epidemiologic studies on coffee consumption and the risk of cutaneous melanoma are inconsistent. We conducted a meta-analysis to assess the associations between the consumption of total coffee, caffeinated coffee and decaffeinated coffee and the risk of cutaneous melanoma, respectively. METHODS:A ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00394-015-1139-z

    authors: Wang J,Li X,Zhang D

    更新日期:2016-06-01 00:00:00

  • Changes in the serum metabolite profile in obese children with weight loss.

    abstract:PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher conce...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-014-0698-8

    authors: Reinehr T,Wolters B,Knop C,Lass N,Hellmuth C,Harder U,Peissner W,Wahl S,Grallert H,Adamski J,Illig T,Prehn C,Yu Z,Wang-Sattler R,Koletzko B

    更新日期:2015-03-01 00:00:00

  • Resveratrol reduces amyloid-beta (Aβ₁₋₄₂)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans.

    abstract:PURPOSE:Resveratrol is a polyphenol present in red wine for which the capability of directly interfering with the hallmark of Alzheimer's disease (AD), i.e. toxic β-amyloid protein (Aβ) aggregation, has been shown recently. Since the stimulation of proteostasis could explain reduced Aβ-aggregation, we searched for prot...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-015-0894-1

    authors: Regitz C,Fitzenberger E,Mahn FL,Dußling LM,Wenzel U

    更新日期:2016-03-01 00:00:00

  • Low FODMAP diet significantly improves IBS symptoms: an Irish retrospective cohort study.

    abstract:INTRODUCTION:There is growing evidence that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) improves symptoms in irritable bowel syndrome (IBS) patients. We aimed to retrospectively investigate the effects of this diet in Irish IBS cohort over a 12-month follow-up period...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-019-02074-6

    authors: Nawawi KNM,Belov M,Goulding C

    更新日期:2020-08-01 00:00:00

  • Choline and polyunsaturated fatty acids in preterm infants' maternal milk.

    abstract:BACKGROUND:Choline, docosahexaenoic acid (DHA), and arachidonic acid (ARA) are essential to fetal development, particularly of the brain. These components are actively enriched in the fetus. Deprivation from placental supply may therefore result in impaired accretion in preterm infants. OBJECTIVE:To determine choline,...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-016-1220-2

    authors: Maas C,Franz AR,Shunova A,Mathes M,Bleeker C,Poets CF,Schleicher E,Bernhard W

    更新日期:2017-06-01 00:00:00

  • Untargeted plasma metabolomic profiles associated with overall diet in women from the SU.VI.MAX cohort.

    abstract:PURPOSE:Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify metabolomic signatures re...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-020-02177-5

    authors: Lécuyer L,Dalle C,Micheau P,Pétéra M,Centeno D,Lyan B,Lagree M,Galan P,Hercberg S,Rossary A,Demidem A,Vasson MP,Partula V,Deschasaux M,Srour B,Latino-Martel P,Druesne-Pecollo N,Kesse-Guyot E,Durand S,Pujos-Guillot E

    更新日期:2020-12-01 00:00:00

  • Can changes in hydrophobicity increase the bioavailability of alpha-tocopherol?

    abstract:BACKGROUND:Bioavailability of fat-soluble vitamins from conventional oral supplements is insufficient in some conditions in which fat digestion and absorption are chronically impaired (e. g. cystic fibrosis). AIM OF THE STUDY:We used a water-soluble form of fatsoluble vitamin E (AQUANOVA solubilisate) to create a nutr...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-005-0556-9

    authors: Back EI,Frindt C,Oćenásková E,Nohr D,Stern M,Biesalski HK

    更新日期:2006-02-01 00:00:00

  • Adaptation of Sprague Dawley rats to long-term feeding of high fat or high fructose diets.

    abstract:BACKGROUND:Present animal models used to emulate type 2 diabetes may not accurately reflect the metabolic changes that occur in humans. AIM OF THE STUDY:The purpose of this research was to evaluate diets reported to induce insulin resistance and impaired glucose metabolism in rats as a potentially useful model for stu...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s003940070016

    authors: Stark AH,Timar B,Madar Z

    更新日期:2000-10-01 00:00:00

  • The role of fortified foods and nutritional supplements in increasing vitamin D intake in Irish preschool children.

    abstract:PURPOSE:There are limited data on the contribution of fortified foods and nutritional supplements to intakes of vitamin D in young children. Our objective was to examine the intake, adequacy, risk of excessive intake and sources of dietary vitamin D. METHODS:The nationally representative cross-sectional dietary survey...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-016-1171-7

    authors: Hennessy Á,Browne F,Kiely M,Walton J,Flynn A

    更新日期:2017-04-01 00:00:00

  • Consumption of wheat bran modified by autoclaving reduces fat mass in hamsters.

    abstract:PURPOSE:To investigate the effect that wheat bran modified by autoclaving (MWB) had on reducing fat accumulation in hamsters fed a hypercholesterolemia- and obesity-inducing diet. METHODS:Male hamsters (n = 45) were randomized into 3 groups and fed a hypercholesterolemia- and obesity-inducing diet with or without 10% ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-013-0583-x

    authors: Harding SV,Sapirstein HD,Rideout TC,Marinangeli CP,Dona AK,Jones PJ

    更新日期:2014-04-01 00:00:00

  • Switching from high-fat diet to foods containing resveratrol as a calorie restriction mimetic changes the architecture of arcuate nucleus to produce more newborn anorexigenic neurons.

    abstract:PURPOSE:These days, obesity threatens the health for which one of the main interventions is calorie restriction (CR). Due to the difficulty of compliance with this treatment, CR mimetics such as resveratrol (RSV) have been considered. The present study compared the effects of RSV and CR on hypothalamic remodeling in a ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-018-1715-0

    authors: Safahani M,Aligholi H,Noorbakhsh F,Djalali M,Pishva H,Modarres Mousavi SM,Alizadeh L,Gorji A,Koohdani F

    更新日期:2019-06-01 00:00:00

  • A cross-sectional study of fatty acids and brain-derived neurotrophic factor (BDNF) in human milk from lactating women following vegan, vegetarian, and omnivore diets.

    abstract:PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-018-1793-z

    authors: Perrin MT,Pawlak R,Dean LL,Christis A,Friend L

    更新日期:2019-09-01 00:00:00