Low FODMAP diet significantly improves IBS symptoms: an Irish retrospective cohort study.

Abstract:

INTRODUCTION:There is growing evidence that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) improves symptoms in irritable bowel syndrome (IBS) patients. We aimed to retrospectively investigate the effects of this diet in Irish IBS cohort over a 12-month follow-up period, including after re-introduction of the high FODMAP foods. METHODS:All the tertiary referrals seen by an FODMAP-trained dietician were reviewed (2013-2016). Patients were evaluated for IBS symptoms by a questionnaire (four-point Likert scale). Subsequently, advice regarding the low FODMAP diet was given. Symptoms' response was assessed at 3-, 6-, and 12-month follow-up, by use of the same questionnaire. Re-introduction of high FODMAP foods was aimed to commence at the subsequent follow-up. RESULTS:A total of 164 patients were identified. Thirty-seven patients were excluded due to failure to attend for follow-up. Hundred and twenty-seven patients (77% patients, of which 85% were female) completed the initial 3-month follow-up. Forty-five percent (74/164) and twenty-five percent (41/164) of the patients had continued follow-up at 6 and 12 months, respectively. Of the 127 patients who returned for follow-up, their commonest baseline symptoms were lethargy (92%), bloating (91%), flatulence (91%), and abdominal pain (89%). All symptoms were significantly improved at the initial follow-up (p < 0.0001 for all). Most patients (66%) were satisfied with their overall symptoms control. In patients who had a longer follow-up duration, all symptoms remained significantly improved compared to the baseline (p < 0.0001 for combined symptoms at 6 and 12 months). After re-introduction of the high FODMAP foods, all patients maintained their symptomatic response (n = 14/14 and n = 7/7 at 6- and 12-month follow-up, respectively). The best symptoms' improvement was seen in those who were fully adherent to the FODMAP diet. CONCLUSION:In this Irish retrospective cohort study, the low FODMAP diet significantly improved all IBS symptoms at 3-, 6-, and 12-month follow-up. Following the re-introduction of the high FODMAP foods in a subgroup of patients, they were able to maintain their long-term symptomatic response up to 9 months. The low FODMAP diet might be continued for longer than 3 months; however, further studies are needed to assess the long-term safety of this diet.

journal_name

Eur J Nutr

authors

Nawawi KNM,Belov M,Goulding C

doi

10.1007/s00394-019-02074-6

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

2237-2248

issue

5

eissn

1436-6207

issn

1436-6215

pii

10.1007/s00394-019-02074-6

journal_volume

59

pub_type

杂志文章
  • Can changes in hydrophobicity increase the bioavailability of alpha-tocopherol?

    abstract:BACKGROUND:Bioavailability of fat-soluble vitamins from conventional oral supplements is insufficient in some conditions in which fat digestion and absorption are chronically impaired (e. g. cystic fibrosis). AIM OF THE STUDY:We used a water-soluble form of fatsoluble vitamin E (AQUANOVA solubilisate) to create a nutr...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-005-0556-9

    authors: Back EI,Frindt C,Oćenásková E,Nohr D,Stern M,Biesalski HK

    更新日期:2006-02-01 00:00:00

  • Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats.

    abstract:AIM:To evaluate the preventive and therapeutic effects of Lactobacilluscasei Zhang on impaired glucose tolerance (IGT) by using fructose-induced hyperinsulinemia rats. METHODS:Rats were fed 25 % fructose solution for hyperinsulinemia with L.casei Zhang for prevention or therapy. Serum levels of insulin, glucagon-like ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-013-0519-5

    authors: Zhang Y,Wang L,Zhang J,Li Y,He Q,Li H,Guo X,Guo J,Zhang H

    更新日期:2014-02-01 00:00:00

  • Alcohol, alcoholic beverages, and melanoma risk: a systematic literature review and dose-response meta-analysis.

    abstract:PURPOSE:Several studies in recent years have investigated the relationship between alcohol intake and melanoma risk, with conflicting results. To help clarify this issue, we conducted a literature review and dose-response meta-analysis of studies published until June 30th, 2017, that examined the association between al...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00394-018-1613-5

    authors: Gandini S,Masala G,Palli D,Cavicchi B,Saieva C,Ermini I,Baldini F,Gnagnarella P,Caini S

    更新日期:2018-10-01 00:00:00

  • Meal replacement based on Human Ration modulates metabolic risk factors during body weight loss: a randomized controlled trial.

    abstract:PURPOSE:A meal replacement may be an effective strategy in the management of obesity to increase antioxidant intake, attenuating oxidative stress and inflammation. In the present study, we investigated the efficacy of a new nutritional supplement to reduce metabolic risk parameters in obese women. METHODS:In a randomi...

    journal_title:European journal of nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00394-013-0598-3

    authors: Alves NE,Enes BN,Martino HS,Alfenas Rde C,Ribeiro SM

    更新日期:2014-04-01 00:00:00

  • A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached.

    abstract:PURPOSE:Higher long-chain polyunsaturated fatty acids (LCP) in infant compared with maternal lipids at delivery is named biomagnification. The decline of infant and maternal docosahexaenoic acid (DHA) status during lactation in Western countries suggests maternal depletion. We investigated whether biomagnification pers...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-011-0245-9

    authors: Luxwolda MF,Kuipers RS,Sango WS,Kwesigabo G,Dijck-Brouwer DA,Muskiet FA

    更新日期:2012-09-01 00:00:00

  • Alpha-lipoic acid preserves the structural and functional integrity of red blood cells by adjusting the redox disturbance and decreasing O-GlcNAc modifications of antioxidant enzymes and heat shock proteins in diabetic rats.

    abstract:PURPOSE:The aim of this study was to investigate whether the daily administration of α-lipoic acid (LA) during 4 weeks prevents the redox disturbance in red blood cells (RBC) described in diabetes METHODS:Multiple low-dose streptozotocin (STZ) diabetes was induced in rats by the administration of 40 mg/kg STZ intraper...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-011-0275-3

    authors: Mirjana M,Jelena A,Aleksandra U,Svetlana D,Nevena G,Jelena M,Goran P,Melita V

    更新日期:2012-12-01 00:00:00

  • Correction to: Large artery stiffness is associated with salt intake in young healthy black but not white adults: the African-PREDICT study.

    abstract::In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected. ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00394-018-1800-4

    authors: Strauss M,Smith W,Kruger R,van der Westhuizen B,Schutte AE

    更新日期:2018-10-01 00:00:00

  • Antiproliferative effect of antioxidant polyphenols from grape in murine Hepa-1c1c7.

    abstract:BACKGROUND:Grapes and wine contain high concentrations of polyphenolic compounds. Although their cancer protective effect has been well documented, their activity as anticarcinogens should be cautiously considered since the molecular bases of action and their applicability to human cancer prevention are still unclear. ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-003-0398-2

    authors: Matito C,Mastorakou F,Centelles JJ,Torres JL,Cascante M

    更新日期:2003-01-01 00:00:00

  • A lavatory urine color (LUC) chart method can identify hypohydration in a physically active population.

    abstract:PURPOSE:To provide a new and efficient at-the-toilet-bowl method of self-assessing urine concentration via urine color (Uc) to identify hypohydration. METHODS:A large athletic population (n = 189) delivered a urine sample, then chose a color panel that was displayed on the back wall of the lavatory stall. Selection wa...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-020-02460-5

    authors: Wardenaar FC,Thompsett D,Vento KA,Bacalzo D

    更新日期:2021-01-08 00:00:00

  • Cognitive performance in relation to hydration status and water intake among older adults, NHANES 2011-2014.

    abstract:PURPOSE:Risks of dehydration and cognitive decline increase with advancing age, yet the relation between dehydration, water intake, and cognitive performance among older adults remains understudied. METHODS:Using data from the 2011-2014 cycles of the Nutrition and Health Examination Survey (NHANES), we tested if calcu...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-019-02152-9

    authors: Bethancourt HJ,Kenney WL,Almeida DM,Rosinger AY

    更新日期:2020-10-01 00:00:00

  • Longitudinal changes in body weight and body composition among women previously treated for breast cancer consuming a high-vegetable, fruit and fiber, low-fat diet.

    abstract:BACKGROUND:Excess adiposity has been shown to be associated with increased risk for breast cancer recurrence, and a plant-based eating pattern has been hypothesized to be protective. Whether a plant-based diet without specific energy goals will result in weight loss or changes in body composition in women who have been...

    journal_title:European journal of nutrition

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00394-004-0487-x

    authors: Thomson CA,Rock CL,Giuliano AR,Newton TR,Cui H,Reid PM,Green TL,Alberts DS,Women's Healthy Eating & Living Study Group.

    更新日期:2005-02-01 00:00:00

  • The effect of three different ad libitum diets for weight loss maintenance: a randomized 18-month trial.

    abstract:PURPOSE:To test the effect of three diets in their ability to sustain weight loss and improve type 2 diabetes (T2D) and cardiovascular disease (CVD) risk markers after 18-month intervention. METHODS:Following a ≥8 % weight loss, 131 healthy, overweight/obese (BMI ± SD 31.5 ± 2.6 kg/m2) men (n = 55) and women (n = 76) ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-015-1116-6

    authors: Due A,Larsen TM,Mu H,Hermansen K,Stender S,Toubro S,Allison DB,Astrup A

    更新日期:2017-03-01 00:00:00

  • Multinational study of major breast milk carotenoids of healthy mothers.

    abstract:BACKGROUND:Carotenoids in serum vary between countries and within populations with evidence suggesting a qualitative relationship to diet. Breast milk carotenoids furnish a source of vitamin A and potentially provide immunoprotection and other health benefits for infants. There have been numerous studies of milk carote...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-003-0403-9

    authors: Canfield LM,Clandinin MT,Davies DP,Fernandez MC,Jackson J,Hawkes J,Goldman WJ,Pramuk K,Reyes H,Sablan B,Sonobe T,Bo X

    更新日期:2003-06-01 00:00:00

  • Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice.

    abstract:PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Bet...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-020-02362-6

    authors: Chen W,Zhang X,Xu M,Jiang L,Zhou M,Liu W,Chen Z,Wang Y,Zou Q,Wang L

    更新日期:2020-08-17 00:00:00

  • Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacyclin.

    abstract:PURPOSE:The aims of this study were to evaluate the antihypertensive effectiveness of different doses of grape seed polyphenols in cafeteria diet-fed hypertensive rats (CHRs) and to establish the mechanism involved in the blood pressure (BP) lowering effect of these compounds in this experimental model of metabolic syn...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-015-0895-0

    authors: Pons Z,Margalef M,Bravo FI,Arola-Arnal A,Muguerza B

    更新日期:2016-03-01 00:00:00

  • Dietary glycaemic load associated with cognitive performance in elderly subjects.

    abstract:PURPOSE:Ageing is associated with loss of cognitive function and an increased risk of dementia which is expected to place growing demands on health and long-term care providers. Among multiple causative factors, evidence suggests that cognitive impairment in older subjects may be influenced by diet. The objective of th...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-014-0737-5

    authors: Power SE,O'Connor EM,Ross RP,Stanton C,O'Toole PW,Fitzgerald GF,Jeffery IB

    更新日期:2015-06-01 00:00:00

  • Associations between serum concentration of flavonoids and breast cancer risk among Chinese women.

    abstract:PURPOSE:In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association bet...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-020-02331-z

    authors: Feng XL,Zhan XX,Zuo LS,Mo XF,Zhang X,Liu KY,Li L,Zhang CX

    更新日期:2020-07-18 00:00:00

  • Macronutrient intake and frailty: the Rotterdam Study.

    abstract:PURPOSE:To investigate the longitudinal association between the macronutrient composition of the diet and frailty. METHODS:Data were obtained from 5205 Dutch middle-aged and older adults participating in the Rotterdam Study. Frailty was measured using a frailty index based on the accumulation of 38 health-related defi...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-019-02131-0

    authors: Verspoor E,Voortman T,van Rooij FJA,Rivadeneira F,Franco OH,Kiefte-de Jong JC,Schoufour JD

    更新日期:2020-10-01 00:00:00

  • Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease: a Danish case-cohort study.

    abstract:PURPOSE:The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). METHODS:We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,0...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-019-02159-2

    authors: Bork CS,Lasota AN,Lundbye-Christensen S,Jakobsen MU,Tjønneland A,Overvad K,Schmidt EB

    更新日期:2020-10-01 00:00:00

  • A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins.

    abstract:PURPOSE:Green tea is thought to possess many beneficial effects on human health. However, the extent of green tea polyphenol biotransformation may affect its proposed therapeutic effects. Catechol-O-methyltransferase (COMT), the enzyme responsible for polyphenolic methylation, has a common polymorphism in the genetic c...

    journal_title:European journal of nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00394-011-0189-0

    authors: Miller RJ,Jackson KG,Dadd T,Nicol B,Dick JL,Mayes AE,Brown AL,Minihane AM

    更新日期:2012-02-01 00:00:00

  • Vegetarian diets in children: a systematic review.

    abstract:PURPOSE:While the prevalence of children on vegetarian diets is assumed to be on the rise in industrialized countries, there are hardly any representative data available. In general, vegetarian diets are presumed to be healthy; nevertheless, there are concerns as to whether the dietary specifications required during in...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,评审

    doi:10.1007/s00394-017-1416-0

    authors: Schürmann S,Kersting M,Alexy U

    更新日期:2017-08-01 00:00:00

  • A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial.

    abstract:PURPOSE:To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. METHODS:In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. S...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-015-0859-4

    authors: Yao P,Lu L,Hu Y,Liu G,Chen X,Sun L,Ye X,Zheng H,Chen Y,Hu FB,Li H,Lin X

    更新日期:2016-02-01 00:00:00

  • Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet.

    abstract:BACKGROUND:While naturally occurring inulin has anti-hyperlipidemic effects in animals and humans, health effects of synthetic inulin with different degrees of fructose polymerization remain poorly understood. AIM OF THE STUDY:Our study aimed at distinguishing health effects of synthetic inulin with different degrees ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-008-0713-z

    authors: Sugatani J,Osabe M,Wada T,Yamakawa K,Yamazaki Y,Takahashi T,Ikari A,Miwa M

    更新日期:2008-06-01 00:00:00

  • Iodine status from childhood to adulthood in females living in North-East Italy: Iodine deficiency is still an issue.

    abstract:PURPOSE:This survey aimed to assess iodine status in a female population at different ages, also investigating their eating habits. METHODS:We measured urinary iodine concentrations (UIC) in: 634 females at puberty and 361 fertile women in 246 of whom were considered also their children (134 daughters and 120 sons). A...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-015-0853-x

    authors: Watutantrige Fernando S,Cavedon E,Nacamulli D,Pozza D,Ermolao A,Zaccaria M,Girelli ME,Bertazza L,Barollo S,Mian C

    更新日期:2016-02-01 00:00:00

  • Emerging technologies and perspectives for nutrition research in European Union 7th Framework Programme.

    abstract::Nutrition trends in Europe are driven by taste, health and convenience. The possibilities of research using new technologies and tools such as nutrigenomics, imaging techniques, nanotechnology, bioinformatics, cognitive sciences, innovative processes are very promising to support these nutrition trends and in particul...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-009-0076-0

    authors: de Froidmont-Görtz IB

    更新日期:2009-12-01 00:00:00

  • Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors.

    abstract:BACKGROUND:Both hempseed oil (HO) and flaxseed oil (FO) contain high amounts of essential fatty acids (FAs); i.e. linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (ALA, 18:3n-3), but almost in opposite ratios. An excessive intake of one essential FA over the other may interfere with the metabolism of the other whil...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-006-0621-z

    authors: Schwab US,Callaway JC,Erkkilä AT,Gynther J,Uusitupa MI,Järvinen T

    更新日期:2006-12-01 00:00:00

  • Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial.

    abstract:PURPOSE:Compared to a healthy population, the gut microbiota in type 2 diabetes presents with several unfavourable features that may impair glucose regulation. The aim of this study was to evaluate the prebiotic effect of inulin-type fructans on the faecal microbiota and short-chain fatty acids (SCFA) in patients with ...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-020-02282-5

    authors: Birkeland E,Gharagozlian S,Birkeland KI,Valeur J,Måge I,Rud I,Aas AM

    更新日期:2020-10-01 00:00:00

  • Micronutrient status in lactating mothers before and after introduction of fortified flour: cross-sectional surveys in Maela refugee camp.

    abstract:BACKGROUND:Deficiency of micronutrients is common in refugee populations. OBJECTIVES:Identify deficiencies and whether provided supplements and wheat flour fortified with 10 micronutrients impacts upon status among breast-feeding women from Maela refugee camp. METHODS:Two sequential cross-sectional studies were condu...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-011-0226-z

    authors: Stuetz W,Carrara VI,McGready R,Lee SJ,Erhardt JG,Breuer J,Biesalski HK,Nosten FH

    更新日期:2012-06-01 00:00:00

  • Associations between exclusive breastfeeding and physical fitness during childhood.

    abstract:PURPOSE:Exposure to breastfeeding improves the survival, health, and development of children; therefore, breast milk is recommended as the exclusive nutrient source for feeding term infants during the first 6 months. This cross-sectional study aimed to determine the possible association between exposure to exclusive br...

    journal_title:European journal of nutrition

    pub_type: 杂志文章

    doi:10.1007/s00394-016-1337-3

    authors: Zaqout M,Michels N,Ahrens W,Börnhorst C,Molnár D,Moreno LA,Eiben G,Siani A,Papoutsou S,Veidebaum T,De Henauw S,IDEFICS consortium.

    更新日期:2018-03-01 00:00:00

  • The effect of the macronutrient composition of breakfast on satiety and cognitive function in undergraduate students.

    abstract:PURPOSE:It is believed that breakfast is an important meal due to its effect on appetite control and cognitive performance, yet little evidence exists to support this hypothesis. METHODS:Using a crossover design, 33 healthy undergraduates (aged 22 ± 2 years with a BMI of 23.5 ± 1.7 kg/m2) were randomized one of four b...

    journal_title:European journal of nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00394-016-1254-5

    authors: Emilien CH,West R,Hollis JH

    更新日期:2017-09-01 00:00:00