Abstract：
PURPOSE:To assess the effect of medium-chain fatty acid (MCFA)-rich mustard oil and polyunsaturated fatty acid (PUFA)-rich mustard oil on erythrocyte membrane composition and osmotic fragility in normal and hypercholesterolemic rats. METHOD:Membrane composition was analyzed using standard kits. Osmotic fragility was determined using method described by Dacie and Lewis. Fatty acid composition of membrane was analyzed using gas chromatographic methods. Membrane shape analysis was performed using scanning electron microscope. RESULTS:Osmotic fragility data suggested that the erythrocyte membrane of hypercholesterolemic rats were relatively more fragile than that of the normal rat's membrane, which could be reversed with the addition of MCFA- and PUFA-rich oil in the diet. The increased plasma cholesterol in hypercholesterolemic rats could also be lowered by the experimental oils. There was also marked changes in the fatty acid composition of the plasma and erythrocyte membrane phospholipids. Polyunsaturated fatty acids decreased in the plasma of the hypercholesterolemic subjects were increased with the treatment of the experimental oils. Shape changes of the membrane holes were observed in the hypercholesterolemic condition, which was brought to normal shape with the administration of the experimental oils. CONCLUSION:In conclusion, rat erythrocytes appear to be deformed and became more fragile in cholesterol-rich blood. This deformity and fragility was partially reversed by experimental oils by virtue of their ability to lower the extent of hypercholesterolemia.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Sengupta A,Ghosh Mdoi
10.1007/s00394-010-0150-7subject
Has Abstractpub_date
2011-09-01 00:00:00pages
411-9issue
6eissn
1436-6207issn
1436-6215journal_volume
50pub_type
杂志文章abstract：:Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases. Nutrition is likely the most important environmental factor that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-014-0654-7
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Iodine fortification programs have been applied in many iodine deficient regions. Iodine excess is also unfavourable, and it is recommended to monitor iodine status by measuring urinary iodine concentration (UIC). The number of samples needed in such monitoring depends on the variation in UIC. However, it is...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0551-5
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher conce...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0698-8
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:No previous study has examined the associations between egg consumption and prevalence of psychological disorders. The present study was conducted to determine the association between egg consumption and depression in a large sample of Iranian adults. METHODS:This cross-sectional study was conducted on 3172 ad...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1739-5
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:Evidence of an association between n-3 polyunsaturated fatty acids (PUFAs) and metabolic syndrome (MS) is limited and inconsistent. We investigated the association between n-3 PUFAs in erythrocytes and the presence of MS in Chinese adults. METHODS:The levels of α-linolenic acid (ALA), eicosapentaenoic acid (EP...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0912-3
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Adherence to Mediterranean diet has been shown to be associated with a better health and greater survival. The aim of the present study was to identify change-points in the relationship between food groups composing Mediterranean diet and overall mortality. METHODS:The population of the Greek EPIC prospecti...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0202-7
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula. METHODS:A nested case-control study was ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1668-3
更新日期：2019-03-01 00:00:00
abstract：:In domestic animals, acid-base balance may be influenced by nutrition. The major research effort in this area has been made on the prevention of hypocalcemic postparturient paresis in dairy cows. This disorder is caused by the sudden increase of calcium secretion into the colostrum. The manipulation of the dietary cat...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s394-001-8352-2
更新日期：2001-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine whether grape polyphenols have a "second-meal effect", modulating glucose and lipid elevations in the postprandial period after two successive meals in subjects with obesity. METHODS:A randomized, double-blind, placebo-controlled, acute clinical trial was conducted. Twent...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02451-6
更新日期：2021-01-02 00:00:00
abstract：PURPOSE:Constitutive activation of the Wnt signaling pathway and its downstream effectors plays a key role in neoplastic transformation. The objective of this study was to investigate the effect of ellagic acid, a plant-derived polyphenol on Wnt/β-catenin signaling and its downstream circuits- NF-κB and mitochondrial a...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0288-y
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:Impaired B vitamin status has been identified as a risk factor for major chronic diseases. This study aims at examining the determinants of plasma folate and vitamin B12 concentrations, considering lifestyle factors and MTHFR polymorphisms. METHODS:A total of 988 women aged 40-65 years from the French E3N coho...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-016-1365-z
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Previous studies have described an important selenium deficiency in a mountain region (Glanle) in the west of Ivory Coast. AIM OF THE STUDY:To assess the antioxidant capacity of subjects from a selenium deficient area in Ivory Coast (Glanle region). METHODS:This study involved 57 subjects, 18 to 69 years o...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-004-0484-0
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:The transcription factor NF-kappaB is suggested to play a pivotal role in atherogenesis by regulating the expression of proinflammatory gene products such as adhesion molecules. Garlic is consumed as food or dietary supplement in order to benefit from its antiatherogenic effect. AIM OF THE STUDY:This study ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-004-0437-7
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Addition of capsaicin to the diet has been shown to increase satiety and thermogenesis. The effects of capsaicin on ghrelin, peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), in relation to changes in hunger and satiety are unknown. AIM:To test the acute effects of a lunch containing capsaicin on gut de...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0006-1
更新日期：2009-06-01 00:00:00
abstract：:Low intracellular magnesium (Mg) contents may be observed in case of severe Mg insufficient intake or because of genetic regulation. This work was conducted to investigate the influence of intracellular Mg content on erythrocyte Mg(2+) influx and efflux in mice with low nutritionally and genetically (MGL and MGH mice)...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-005-0579-2
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:While naturally occurring inulin has anti-hyperlipidemic effects in animals and humans, health effects of synthetic inulin with different degrees of fructose polymerization remain poorly understood. AIM OF THE STUDY:Our study aimed at distinguishing health effects of synthetic inulin with different degrees ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-008-0713-z
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:Glucosinolates/isothiocyanates are an established class of naturally occurring chemopreventive agents, a principal mechanism of action being to limit the generation of genotoxic metabolites of chemical carcinogens, as a result of modulation of cytochrome P450 and phase II detoxification enzymes. The objective o...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-012-0397-2
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Inulin-type fructans or chains with mainly beta[2-1] linked fructose molecules escape the ingestion procedure in the small intestine and are fermented by the microflora, and are known to increase colonic absorption of minerals in animals. The fermentation rate in the large bowel into short-chain fatty acids ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-003-0390-x
更新日期：2003-04-01 00:00:00
abstract：PURPOSE:Inadequate iodine intake may result in iodine deficiency disorders (IDD). Thus, for more than 50 years, policies for the regulation of salt fortification with iodine have existed in Brazil. In 2003, a study on 6-14-year-old schoolchildren from regions of the state of São Paulo showed a median urinary iodine con...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0239-7
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Iron deficiency in children is a major worldwide nutritional problem. An oat beverage was developed for 1- to 3-year-old children and different treatments were used to improve the iron bioavailability. AIM OF THE STUDY:To investigate the effects of citric acid addition, phytase treatment and supplementation...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-006-0637-4
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:The primary role of polymorphonuclear neutrophils (PMNs) is to destroy pathogenic microorganisms after phagocytosis by producing reactive oxygen species (ROS) and toxic molecules. However, PMNs produce sufficient amounts of ROS during an oxidative burst to be autotoxic and detrimental to their own functions ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-004-0501-3
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer's disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. METHODS:We used summary statistics data for single-nucleotide polymorphisms associated with plasm...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02126-x
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Few studies have evaluated the association of fruit and vegetable (FV) intake and pre-diabetes. However, these studies are very limited and incomplete. Therefore, the aim of our study was to compare FV consumption and their subgroups between pre-diabetic and control subjects. METHODS:This case-control study in...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1569-x
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Amaranth is a crop that can be grown in different soils and climates, being resistant to high temperatures, drought, and some pests. The amaranth plant has nutritional qualities and desirable biological properties. AIM OF THE STUDY:The aim of the study is to investigate the potential antitumor properties of...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-009-0051-9
更新日期：2010-03-01 00:00:00
abstract：PURPOSE:Accumulating evidence suggests that inhibitors of aldose reductase (AR) may prevent hyperglycemia-induced long-term complications in diabetes mellitus. In the present study, we evaluated the AR inhibitory potential of ethanolic (EtOH) extracts from 22 seaweed species. METHODS:AR inhibitory activities of the se...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0521-y
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:We examined whether high doses of folic acid and iron supplementation in early-to-mid pregnancy affect the risk of preterm birth, low birth weight, and small for gestational age neonates, in the mother-child cohort in Crete, Greece (Rhea study). METHODS:We included 1,279 women with singleton pregnancies with c...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-012-0339-z
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:In addition to regulating calcium homoeostasis and bone health, vitamin D influences vascular and metabolic processes including endothelial function (EF) and insulin signalling. This systematic review and meta-analysis of randomised clinical trials (RCTs) were conducted to investigate the effect of vitamin D...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00394-016-1159-3
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:In this study, we sought to find the effects and mechanisms of probiotic Lactobacillus casei Zhang (L. casei Zhang) on the pro-inflammatory cytokine production and hepatic inflammatory response in a rat model of acute liver failure induced by lipopolysaccharide (LPS) and d-galactosamine (GalN). METHODS:Male Wi...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0904-3
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:Bioavailability is a critical feature in the assessment of the role of micronutrients in human health. Poorly bioavailable micronutrients like carotenoids may reach significant concentrations in the gastrointestinal tract where they may exert biological actions. PURPOSE:We evaluated a simple collection pr...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-015-0939-5
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Globally, around 20 million children suffer from severe acute malnutrition (SAM). Identifying a more economical treatment for those affected has the potential to make treatment more available and improve prognosis for recovery and future health. DESIGN/METHODS:The double-blind randomized study...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-019-01975-w
更新日期：2020-04-01 00:00:00
