Abstract：
PURPOSE:Recent epidemiological studies have shown that habitual consumption of extra virgin olive oil (EVOO), the characteristic culinary fat of the Mediterranean area, is effective in the prevention of diverse types of digestive disorders such as inflammatory bowel disease. Many of these benefits are, in addition to its high proportion of oleic acid, due to the high content of phenolic compounds. METHODS:Six-week-old mice were randomized into three dietary groups: standard, EVOO and hydroxytyrosol-enriched EVOO. After 30 days, mice that were exposed to 3% DSS for 5 days developed acute colitis that progressed to severe chronic inflammation during a regime of 21 days of water. RESULTS:Diets enriched with EVOO significantly attenuated the clinical and histological signs of damage, improving results from disease activity index and reducing about 50% the mortality caused by DSS. Moreover, hydroxytyrosol supplement showed better results. Cytokines study showed that TNF-α was maintained near to sham control and IL-10 levels were significantly improved in EVOO and EVOO plus hydroxytyrosol diet-DSS groups. In the same way, COX-2 and iNOS were downregulated, and the activation of p38 MAPK was reduced. We also observed a higher significant reduction in iNOS in hydroxytyrosol-enriched EVOO compared with EVOO alone. CONCLUSIONS:EVOO diets exerted a noteworthy beneficial effect in chronic DSS-induced colitis by cytokine modulation and COX-2 and iNOS reduction via downregulation of p38 MAPK. In addition to the beneficial effect by EVOO, supplementation of the diet with hydroxytyrosol may improve chronic colitis through iNOS downregulation plus its antioxidant capacity.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Sánchez-Fidalgo S,Sánchez de Ibargüen L,Cárdeno A,Alarcón de la Lastra Cdoi
10.1007/s00394-011-0235-ysubject
Has Abstractpub_date
2012-06-01 00:00:00pages
497-506issue
4eissn
1436-6207issn
1436-6215journal_volume
51pub_type
杂志文章abstract：PURPOSE:The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula. METHODS:A nested case-control study was ...
journal_title：European journal of nutrition
pub_type： 杂志文章
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abstract：BACKGROUND:Fish and fish oils are rich in the two long-chain polyunsaturated fatty acids (LCPUFAs) eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). The n-3 LCPUFAs have been reported to have beneficial effects on cardiovascular functions, but their role in relation to immune functions is st...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-003-0390-x
更新日期：2003-04-01 00:00:00
abstract：PURPOSE:Experimental investigations in rodents have contributed significantly to our current understanding of the potential importance of the gut microbiome and brain interactions for neurotransmitter expression, neurodevelopment, and behaviour. However, clinical evidence to support such interactions is still scarce. T...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-018-1813-z
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-012-0461-y
更新日期：2013-08-01 00:00:00
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2017-06-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2016-06-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
