Abstract：
PURPOSE:The effect of 40 μg (1,600 IU) per day of vitamin D(3) on serum 25-hydroxyvitamin D (25(OH)D) and markers of bone and mineral metabolism was evaluated. METHODS:This intervention study was designed as a double-blind randomised controlled trial. Forty-five community-dwelling subjects (32 females), age 55-84 years, at 58° North latitude were supplemented for 1 year with 40 μg vitamin D(3) plus 1,000 mg calcium per day, or with 1,000 mg calcium per day for controls. Safety parameters and 25(OH)D, intact parathyroid hormone (PTH), ionized calcium, bone-specific alkaline phosphatase (BALP), and tartrate-resistant acid phosphatase isoform 5b (TRACP5b) were measured over the study period. RESULTS:All subjects supplemented with vitamin D(3) reached a 25(OH)D level above 50 nmol/L. Mean (SD) serum 25(OH)D increased from 50.4 (13.5) nmol/L to 84.2 (17.5) nmol/L, range 55.0-125.0 nmol/L in the vitamin D(3) supplemented group and the corresponding levels for the control group were 47.3 (14.1) nmol/L and 45.7 (13.4) nmol/L, range 26.0-73.0 nmol/L. No serious adverse event was recorded and the highest 25(OH)D level reached, 125.0 nmol/L, is well below toxic levels. BALP and TRACP5b did not change significantly over the study period. CONCLUSIONS:This trial suggests that a daily supplementation with 40 μg vitamin D(3) is sufficient to secure a 25(OH)D level of 50 nmol/L. No side effects were observed in the study group.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Toss G,Magnusson Pdoi
10.1007/s00394-011-0271-7subject
Has Abstractpub_date
2012-12-01 00:00:00pages
939-45issue
8eissn
1436-6207issn
1436-6215journal_volume
51pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Carotenoids in serum vary between countries and within populations with evidence suggesting a qualitative relationship to diet. Breast milk carotenoids furnish a source of vitamin A and potentially provide immunoprotection and other health benefits for infants. There have been numerous studies of milk carote...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-003-0403-9
更新日期：2003-06-01 00:00:00
abstract：PURPOSE:The secoiridoid oleuropein, as found in olives and olive leaves, modulates some biomarkers of diabetes risk in vivo. A possible mechanism may be to attenuate sugar digestion and absorption. METHODS:We explored the potential of oleuropein, prepared from olive leaves in a water soluble form (OLE), to inhibit dig...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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abstract：PURPOSE:To investigate the effect that wheat bran modified by autoclaving (MWB) had on reducing fat accumulation in hamsters fed a hypercholesterolemia- and obesity-inducing diet. METHODS:Male hamsters (n = 45) were randomized into 3 groups and fed a hypercholesterolemia- and obesity-inducing diet with or without 10% ...
journal_title：European journal of nutrition
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abstract：PURPOSE:To assess the effectiveness of a dietary intervention combined with fortified dairy products on bone metabolism and bone mass indices in postmenopausal women. METHODS:Forty postmenopausal women (55-65 years old) were equally randomized into a dietary group (DG), receiving daily and for 30 months, 1,200 mg of c...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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abstract：PURPOSE:This study aimed to assess the dietary patterns of adolescents using a food-based diet quality index and their compliance with a healthy dietary guideline METHODS: Participants included 71,553 Brazilian adolescents (12-17 years old) from the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectiona...
journal_title：European journal of nutrition
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abstract：PURPOSE:This project sought to test the role of diet-related inflammation in modulating the risk of oesophageal cancer. METHODS:A nationwide population-based case-control study was conducted from 1 December 1994 through 31 December 1997 in Sweden. All newly diagnosed patients with adenocarcinoma of the oesophagus or g...
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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pub_type： 已发布勘误
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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abstract：OBJECTIVE:Epidemiologic evidence on the potential effects of dietary acid load on frailty is lacking. This cross-sectional study examined the association between dietary acid load and frailty. METHODS:This study was based on self-reported data obtained from 2176 Japanese women aged 65-94 years. Dietary acid load was c...
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析
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更新日期：2014-01-01 00:00:00
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更新日期：2017-08-01 00:00:00
