Abstract：
BACKGROUND:Bioavailability of fat-soluble vitamins from conventional oral supplements is insufficient in some conditions in which fat digestion and absorption are chronically impaired (e. g. cystic fibrosis). AIM OF THE STUDY:We used a water-soluble form of fatsoluble vitamin E (AQUANOVA solubilisate) to create a nutritional supplement (NS) in the form of vitaminized gummi bears (with micellised water-soluble alpha-tocopheryl acetate (100 IU) and 400 mg crystalline vitamin C). We assessed the bioavailability of the NS in comparison to conventional preparations. METHODS:The trial consisted of three study days (d0: NS sucked; d10: NS swallowed; d20: reference products swallowed). A total of 14 subjects (6 male/8 female), aged 25.3 (22.7-35.3) years, BMI 24.3 (19.0-31.7) kg/m(2) participated in the study. They had blood samples drawn after fasting for >or=12 hours and then 1, 5, 15, 30, 60, 120, 180, 240, 300 and 320 minutes after ingesting the vitamins. HPLC and a colorimetric method were used to determine vitamin E and vitamin C, respectively. Areas under the curve (AUC(0-320min)) and maximum increases in plasma concentrations (Delta concentration) were calculated to assess bioavailability. RESULTS:The AUCs(0-320min) of alpha-tocopherol from d0 were significantly larger (p = 0.016) when compared to d20. Moreover, the maximum increase in alpha-tocopherol plasma concentrations was significantly higher for d0 (p = 0.023) and d10 (p = 0.002) when compared to d20. CONCLUSIONS:Short-term bioavailability of AQUANOVA micellised fat-soluble vitamin E from our NS was significantly higher than from regular supplements. The NS will now be tested for its clinical efficacy in a randomized double-blind controlled intervention trial with CF patients.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Back EI,Frindt C,Oćenásková E,Nohr D,Stern M,Biesalski HKdoi
10.1007/s00394-005-0556-9keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
1-6issue
1eissn
1436-6207issn
1436-6215journal_volume
45pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. AIM OF THE STUDY:To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel t...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-003-0421-7
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:Intake of specific nutrients has been linked to mental states and various indices of cognitive performance although the effects are often subtle and difficult to interpret. Measurement of so-called objective variables (e.g. reaction times) is often considered to be the gold standard for assessing outcomes in th...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-015-1143-3
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abstract：BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...
journal_title：European journal of nutrition
pub_type： 杂志文章,多中心研究
doi：10.1007/s00394-012-0473-7
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine whether grape polyphenols have a "second-meal effect", modulating glucose and lipid elevations in the postprandial period after two successive meals in subjects with obesity. METHODS:A randomized, double-blind, placebo-controlled, acute clinical trial was conducted. Twent...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02451-6
更新日期：2021-01-02 00:00:00
abstract：BACKGROUND:Lutein is a carotenoid that may play a role in eye health. Human milk typically contains higher concentrations of lutein than infant formula. Preliminary data suggest there are differences in serum lutein concentrations between breastfed and formula-fed infants. AIM OF THE STUDY:To measure the serum lutein ...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:While a relationship between alcohol and cardiovascular risk factors is well established, data suggest that the type of alcoholic beverage could modulate this relationship. AIM OF THE STUDY:To determine whether drinking patterns modulate the relationship between alcohol and cardiovascular risk factors. MET...
journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
abstract：PURPOSE:To examine whether a body shape index (ABSI) calculated by using waist circumference (WC) adjusted for height and weight could improve the predictive performances for cardiovascular disease (CVD) of the Framingham's general CVD algorithm and to compare its predictive performances with other anthropometric measu...
journal_title：European journal of nutrition
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abstract：BACKGROUND:Antioxidant defence has been reported to decrease, and oxidative stress to increase, after oral glucose loading in both normal and diabetic subjects. If confirmed in normal subjects, glucose-induced antioxidant depletion has important implications for health in relation to the modern, sugar-rich diet. AIM O...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-004-0518-7
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journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
abstract：PURPOSE:Pomegranate fruit, Punica granatum L. (Punicaceae), and its constituents have been shown to inhibit inflammation. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. METHODS:An enzyme immunoassay (EIA) was used to measure prostag...
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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journal_title：European journal of nutrition
pub_type： 已发布勘误
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更新日期：2020-12-05 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02126-x
更新日期：2020-06-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2020-06-10 00:00:00
abstract：PURPOSE:L-Theanine is the major free amino acid present in tea (Camellia sinensis L.). The effects of several tea constituents on male reproduction have been investigated, but L-theanine has been overlooked. Sertoli cells (SCs) are essential for the physical and nutritional support of germ cells. In this study, we aime...
journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2013-02-01 00:00:00
abstract：PURPOSE:Although several researches have demonstrated that rooibos extract has hypoglycemic effect, the role of aspalathin, a main polyphenol in the extract, remains unclear. Our aims were to find specific mechanisms for anti-diabetic action of aspalathin employing a rat skeletal muscle-derived cell line (L6 myocytes) ...
journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
