Abstract:
BACKGROUND:Antioxidant defence has been reported to decrease, and oxidative stress to increase, after oral glucose loading in both normal and diabetic subjects. If confirmed in normal subjects, glucose-induced antioxidant depletion has important implications for health in relation to the modern, sugar-rich diet. AIM OF THE STUDY:To investigate changes in plasma biomarkers of oxidant:antioxidant balance in non-diabetic subjects following oral glucose loading. Baseline inter-relationships between biomarkers of glycaemic control, oxidant:antioxidant balance and inflammation were also explored. METHODS:A single-blinded, placebo-controlled, crossover intervention trial involving 10 healthy, consenting subjects. Venous blood was collected after ingestion of 75 g glucose in 300 mL water, or of water alone. Blood was collected at 0 time (fasting) and 30, 60, 90, 120 min post-ingestion. Within 2 weeks the procedure was repeated with volunteers crossed-over onto the other treatment. Plasma total antioxidant capacity (as the FRAP value), ascorbic acid, alpha-tocopherol, uric acid, malondialdehyde (MDA), allantoin and high sensitivity C-reactive protein (hsCRP), glucose and insulin, were measured in all samples. Paired results post-glucose and post-water at each time interval were compared using the Wilcoxon matched-pairs signed-ranks test. RESULTS:Normal glucose tolerance was observed in all subjects, although, as expected, plasma glucose and insulin increased significantly (p < 0.05, n = 10) after glucose loading. Post-glucose responses in plasma FRAP and the individual antioxidants tested were not significantly different to the responses seen post-water, although both FRAP and alpha-tocopherol decreased slightly. Neither were post-glucose changes in plasma MDA and allantoin, putative biomarkers of oxidative stress, significantly different to those after intake of water alone. Plasma FRAP and alpha-tocopherol also decreased slightly, but not significantly, after intake of water. A significant direct correlation (r = 0.867, p < 0.001, n = 10) was found between fasting allantoin and (log transformed) hsCRP concentrations. CONCLUSIONS:These new data from a controlled intervention trial indicate that acute, transient increases in plasma glucose following oral intake of a large glucose load do not, as previously reported, cause a significant decrease in plasma antioxidants or increase oxidative stress in non-diabetic subjects. This is reassuring given the large quantities of sugar ingested by children and adolescents. However, a small decrease in plasma antioxidant capacity was seen after ingestion of water and of glucose, and it is possible that intake of glucose without concomitant intake of antioxidants in susceptible individuals may cause oxidative stress. Further work is needed in relation to diabetic subjects and a possible glucose threshold for this. The finding of a direct relationship between allantoin, a biomarker of oxidative stress, and hsCRP, a marker of inflammation and CHD predictor, in healthy subjects is interesting and indicates a link between sub-clinical inflammation and oxidative stress.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Ma SW,Tomlinson B,Benzie IFdoi
10.1007/s00394-004-0518-7keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
250-4issue
4eissn
1436-6207issn
1436-6215journal_volume
44pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...
journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
doi:10.1007/s00394-012-0473-7
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:There is considerable variation in incremental circulating 25-hydroxyvitamin D (25OHD) levels on vitamin D supplements, even when similar age groups and identical vitamin D doses are compared. We therefore aimed to investigate the importance of body weight for the dose-response relation in circulating 25OHD. M...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-013-0634-3
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Quercetin is one of potential antidiabetic substances because of its powerful antioxidant and anti-inflammatory actions. The purpose of this study is to estimate daily quercetin intake and assess the relationship between dietary quercetin intake and the prevalence of type 2 diabetes mellitus (T2DM) in a Chinese...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1713-2
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02087-1
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:Risks of dehydration and cognitive decline increase with advancing age, yet the relation between dehydration, water intake, and cognitive performance among older adults remains understudied. METHODS:Using data from the 2011-2014 cycles of the Nutrition and Health Examination Survey (NHANES), we tested if calcu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02152-9
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:We examined associations between substitution of red meat (total, processed and unprocessed, low fat and high fat) with poultry or fish and substitution of processed red meat with unprocessed red meat and the risk of type 2 diabetes. METHODS:A cohort of 53,163 participants from the Danish Diet, Cancer and Heal...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1820-0
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:To examine the determinants of adiponectin levels (i) in 23 women with anorexia nervosa (mean BMI 15.0 +/- 1.2) and 43 healthy normal weight females (mean BMI 22.3 +/- 2.3; cross-sectional design) as well as (ii) after six and twelve weeks of weight gain in subgroups of 18 and 11 anorectic patients (mean weig...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-005-0533-3
更新日期:2005-09-01 00:00:00
abstract::In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected. ...
journal_title:European journal of nutrition
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00394-018-1800-4
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher conce...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0698-8
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:DNA methylation is an important epigenetic process for transcriptional control of human genome including those genes involved in cancer initiation and progression. Clinical studies have suggested that biological explanation to the protective effect of some nutrients could be linked with the DNA methylation. ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-009-0010-5
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:Reports on the protective effect of a Mediterranean diet on mortality usually refer to populations from Mediterranean countries, leaving uncertain whether really diet is the fundamental cause. Our aim was to examine the effect of a Mediterranean diet on mortality in Switzerland, a country combining cultural inf...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0695-y
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin-angiotensin-aldosterone system, in healthy humans. METHODS:A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingest...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-1110-z
更新日期:2017-03-01 00:00:00
abstract::The potential impact on health of diets rich in free sugars, and particularly fructose, is of major concern. The focus of this review is the impact of these sugars on insulin resistance and obesity, and the associated risk of developing type 2 diabetes. Much of the concern is focussed on specific metabolic effects of ...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-016-1340-8
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Epidemiologic evidence on the potential effects of dietary acid load on frailty is lacking. This cross-sectional study examined the association between dietary acid load and frailty. METHODS:This study was based on self-reported data obtained from 2176 Japanese women aged 65-94 years. Dietary acid load was c...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1449-4
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Conjugated linoleic acid (CLA) has received great attention in recent years because of its pleiotropic biological activities, but considerably fewer studies have been published addressing its role in serum lipids and atherosclerosis compared to other topics covered. AIMS OF THE STUDY:The aim of the present ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-007-0653-z
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Conifer seeds are used for food preparation in several countries. Aim of the study To assess the lipid-lowering and antiatherogenic properties of maritime pine (Pinuspinaster) seed oil. METHODS:The effects of maritime pine oil supplementation (20% w/w) for 2 weeks were compared to those of coconut and sunfl...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s394-001-8355-6
更新日期:2001-12-01 00:00:00
abstract:PURPOSE:Epidemiologic data linking adherence to the dietary approaches to stop hypertension (DASH) diet and metabolic abnormalities is sparse and inconsistent. The association between habitual intake of the DASH diet and metabolic syndrome (MetS) has not been investigated in the Middle East. We aimed to determine wheth...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0723-y
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:This project sought to test the role of diet-related inflammation in modulating the risk of oesophageal cancer. METHODS:A nationwide population-based case-control study was conducted from 1 December 1994 through 31 December 1997 in Sweden. All newly diagnosed patients with adenocarcinoma of the oesophagus or g...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0987-x
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Previously, anthocyanin-rich blueberry treatments have shown positive effects on cognition in both animals and human adults. However, little research has considered whether these benefits transfer to children. Here we describe an acute time-course and dose-response investigation considering whether these cognit...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-1029-4
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02395-x
更新日期:2020-10-01 00:00:00
abstract:: ...
journal_title:European journal of nutrition
pub_type: 评论,信件
doi:10.1007/s00394-018-1836-5
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mec...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1275-0
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:In addition to regulating calcium homoeostasis and bone health, vitamin D influences vascular and metabolic processes including endothelial function (EF) and insulin signalling. This systematic review and meta-analysis of randomised clinical trials (RCTs) were conducted to investigate the effect of vitamin D...
journal_title:European journal of nutrition
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00394-016-1159-3
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The best nutritional option for newborn infants is mother's milk. However, some newborn babies may not be exclusively breastfed during the first months of life, potentially leading to reduced overall health status and the early onset of allergic diseases in some infants. Considerable research has been devote...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
doi:10.1007/s003940070024
更新日期:2000-06-01 00:00:00
abstract:PURPOSE:Aim of this study was to identify a possible relationship among dietary fatty acids (FA) intake, FA adipose tissue (AT) profile and cancer condition in lean vs obese subjects affected or not by colorectal cancer (CRC). Actually, inadequate dietary habits together with physical inactivity are primary determinant...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02003-7
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Globally, around 20 million children suffer from severe acute malnutrition (SAM). Identifying a more economical treatment for those affected has the potential to make treatment more available and improve prognosis for recovery and future health. DESIGN/METHODS:The double-blind randomized study...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-019-01975-w
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Inadequate iodine intake may result in iodine deficiency disorders (IDD). Thus, for more than 50 years, policies for the regulation of salt fortification with iodine have existed in Brazil. In 2003, a study on 6-14-year-old schoolchildren from regions of the state of São Paulo showed a median urinary iodine con...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0239-7
更新日期:2012-08-01 00:00:00
abstract:AIM:Urine concentration measured via osmolality (U OSM) and specific gravity (U SG) reflects the adequacy of daily fluid intake, which has important relationships to health in pregnant (PREG) and lactating (LACT) women. Urine color (U COL) may be a practical, surrogate marker for whole-body hydration status. PURPOSE:T...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1085-9
更新日期:2017-02-01 00:00:00
abstract::The objective of this study was to assess the effect of conjugated linoleic acid isomers (CLAs) on the expression and activity of phospholipases A(2) (PLA(2)) in human macrophages. Macrophages were incubated with 30 microM cis-9, trans-11 and trans-10, cis-12 CLAs for 48 h. After incubation, the total activity of phos...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0626-7
更新日期:2007-02-01 00:00:00
abstract:PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1687-0
更新日期:2018-10-01 00:00:00