Abstract:
PURPOSE:This project sought to test the role of diet-related inflammation in modulating the risk of oesophageal cancer. METHODS:A nationwide population-based case-control study was conducted from 1 December 1994 through 31 December 1997 in Sweden. All newly diagnosed patients with adenocarcinoma of the oesophagus or gastroesophageal junction and a randomly selected half of patients with oesophageal squamous cell carcinoma were eligible as cases. Using the Swedish Registry of the Total Population, the control group was randomly selected from the entire Swedish population and frequency-matched on age (within 10 years) and sex. The literature-derived dietary inflammatory index (DII) was developed to describe the inflammatory potential of diet. DII scores were computed based on a food frequency questionnaire. Higher DII scores indicate more pro-inflammatory diets. Odds ratios and 95 % confidence intervals (CI) were computed to assess risk associated between DII scores and oesophageal cancer using logistic regression adjusted by potential confounders. RESULTS:In total, 189 oesophageal adenocarcinomas, 262 gastroesophageal junctional adenocarcinomas, 167 oesophageal squamous cell carcinomas, and 820 control subjects were recruited into the study. Significant associations with DII were observed for oesophageal squamous cell carcinoma (ORQuartile4vs1 4.35, 95 % CI 2.24, 8.43), oesophageal adenocarcinoma (ORQuartile4vs1 3.59, 95 % CI 1.87, 6.89), and gastroesophageal junctional adenocarcinoma (ORQuartile4vs1 2.04, 95 % CI 1.24, 3.36). Significant trends across quartiles of DII were observed for all subtypes of oesophageal cancer. CONCLUSIONS:Diet-related inflammation appears to be associated with an increased risk of oesophageal cancer, regardless of histological type.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Lu Y,Shivappa N,Lin Y,Lagergren J,Hébert JRdoi
10.1007/s00394-015-0987-xsubject
Has Abstractpub_date
2016-06-01 00:00:00pages
1683-94issue
4eissn
1436-6207issn
1436-6215pii
10.1007/s00394-015-0987-xjournal_volume
55pub_type
杂志文章abstract:PURPOSE:To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin-angiotensin-aldosterone system, in healthy humans. METHODS:A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingest...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-1110-z
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Chronic sugar-sweetened beverage (SSB) consumption is associated with obesity and type 2 diabetes mellitus (T2DM). Hyperglycaemia contributes to metabolic alterations observed in T2DM, such as reduced oxidative capacity and elevated glycolytic and lipogenic enzyme expressions in skeletal muscle tissue. We aimed...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
doi:10.1007/s00394-012-0401-x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Antioxidants are believed to prevent many types of disease. Some previous studies suggest that dietary supplementation with vitamin C results in a decrease in the level of one of the markers of oxidative damage-8-oxoguanine in the DNA of peripheral blood mononuclear cells (PBMC). AIM OF TRIAL: To investigate...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-005-0569-4
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...
journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
doi:10.1007/s00394-012-0473-7
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Ellagitannins are high molecular weight polyphenols present in high quantities in various food products. They are metabolized by human and animal gut microbiota to postbiotic metabolites-urolithins, bioavailable molecules of a low molecular weight. Following absorption in the gut, urolithins rapidly undergo pha...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02386-y
更新日期:2020-09-22 00:00:00
abstract:BACKGROUND:Vitamins A, E and C, and uric acid, which can scavenge free radicals should also protect DNA from the damage. It is reasonable to assume that agents that decrease oxidative DNA damage should also decrease subsequent cancer development. AIM OF THE STUDY:A relationship between basal level of antioxidants (vit...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0642-7
更新日期:2007-04-01 00:00:00
abstract:PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Bet...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02362-6
更新日期:2020-08-17 00:00:00
abstract:AIM:To evaluate the preventive and therapeutic effects of Lactobacilluscasei Zhang on impaired glucose tolerance (IGT) by using fructose-induced hyperinsulinemia rats. METHODS:Rats were fed 25 % fructose solution for hyperinsulinemia with L.casei Zhang for prevention or therapy. Serum levels of insulin, glucagon-like ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0519-5
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:Cordyceps sinensis has been regarded as a precious tonic food and herbal medicine in China for thousands of years. The exopolysaccharide (EPS) from an anamorph of Cordyceps sinensis was found to have antitumor immunomodulatory activity. Mature dendritic cells play a role in initiating antitumor immunity, so we ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0373-x
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:The objective of the present study was to test the hypothesis that N-acetylcysteine (NAC) may play beneficial roles against intrauterine growth retardation (IUGR)-induced hepatic damage in suckling piglets. METHODS:Fourteen IUGR and seven normal birth weight (NBW) neonatal male piglets were selected. Piglets w...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1322-x
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:The combined hyperglycemia lowering and antioxidant actions of α-lipoic acid (LA) contribute to its usefulness in preventing renal injury and other diabetic complications. The precise mechanisms by which LA alters diabetic oxidative renal injury are not known. We hypothesized that LA through its hypoglycemic ef...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0452-z
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Vegetarian and vegan diets have gained popularity in Switzerland. The nutritional status of individuals who have adopted such diets, however, has not been investigated. The aim of this study was to assess the intake and status of selected vitamins and minerals among vegetarian and vegan adults living in Switzer...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1079-7
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Recent epidemiological studies have shown that habitual consumption of extra virgin olive oil (EVOO), the characteristic culinary fat of the Mediterranean area, is effective in the prevention of diverse types of digestive disorders such as inflammatory bowel disease. Many of these benefits are, in addition to i...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-011-0235-y
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:We examined associations between substitution of red meat (total, processed and unprocessed, low fat and high fat) with poultry or fish and substitution of processed red meat with unprocessed red meat and the risk of type 2 diabetes. METHODS:A cohort of 53,163 participants from the Danish Diet, Cancer and Heal...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1820-0
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Choline, docosahexaenoic acid (DHA), and arachidonic acid (ARA) are essential to fetal development, particularly of the brain. These components are actively enriched in the fetus. Deprivation from placental supply may therefore result in impaired accretion in preterm infants. OBJECTIVE:To determine choline,...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-016-1220-2
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:These days, obesity threatens the health for which one of the main interventions is calorie restriction (CR). Due to the difficulty of compliance with this treatment, CR mimetics such as resveratrol (RSV) have been considered. The present study compared the effects of RSV and CR on hypothalamic remodeling in a ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1715-0
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Risks of dehydration and cognitive decline increase with advancing age, yet the relation between dehydration, water intake, and cognitive performance among older adults remains understudied. METHODS:Using data from the 2011-2014 cycles of the Nutrition and Health Examination Survey (NHANES), we tested if calcu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02152-9
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:High added sugar consumption has been associated with the development of metabolic syndrome (MetS). The American Heart Association (AHA) diet is designed to prevent and treat MetS; however, it remains unclear whether the AHA diet is effective on decreasing added sugar consumption. The aim of our study was to...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-017-1390-6
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher conce...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-014-0698-8
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Iodine deficiency affects 30% of populations worldwide. The amount of thyroglobulin (Tg) in blood increases in iodine deficiency and also in iodine excess. Tg is considered as a sensitive index of iodine status in groups of children and adults, but its usefulness for individuals is unknown. The aim of this stud...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1410-6
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Observational studies have frequently reported that low blood folate concentrations are associated with poor cognitive performance. Our previous studies have shown the potential beneficial effect on the metabolite levels of methionine cycle and peripheral blood inflammatory cytokines from 6- and 12-month folic ...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-017-1598-5
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To examine whether a body shape index (ABSI) calculated by using waist circumference (WC) adjusted for height and weight could improve the predictive performances for cardiovascular disease (CVD) of the Framingham's general CVD algorithm and to compare its predictive performances with other anthropometric measu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0833-1
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To investigate whether age influences colonic polyphenol metabolism. METHODS:Healthy participants, younger (n = 8; 23-43 years) and older (n = 13; 51-76 years), followed a 3-day low-polyphenol diet (LPD) and a 3-day high-polyphenol diet (HPD). Urinary phenolic acids (PA), short chain fatty acids (SCFA), pH and...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1625-1
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:Walnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer. METHODS:COLO205 cells were pretreated with WPE and then stimulated with tu...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1704-3
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mec...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1275-0
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1687-0
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effe...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1385-3
更新日期:2018-04-01 00:00:00
abstract:BACKGOUND:Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE:To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postpr...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-018-1612-6
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:A high intake of whole grains containing soluble fiber has been shown to lower glucose and insulin responses in overweight humans and humans with type 2 diabetes. AIM OF THE STUDY:We investigated the linearity of this response after consumption of 5 breakfast cereal test meals containing wheat and/or barley...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-009-0778-3
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Both hempseed oil (HO) and flaxseed oil (FO) contain high amounts of essential fatty acids (FAs); i.e. linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (ALA, 18:3n-3), but almost in opposite ratios. An excessive intake of one essential FA over the other may interfere with the metabolism of the other whil...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-006-0621-z
更新日期:2006-12-01 00:00:00