Abstract：
PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is currently the leading cause of chronic liver disease in developing countries. The pathogenesis is complex, and there is currently no effective treatment. Betaine is an essential intermediate in choline catabolism and an important component of the methionine cycle. Betaine deficiency is associated with NAFLD severity, and its mechanism needs to be further elaborated. METHODS:In this study, an NAFLD mouse model was established by feeding ApoE-/- mice a high-fat diet. The effects of betaine on NAFLD were investigated, including its mechanism. RESULTS:In this study, after treatment with betaine, blood lipid levels and liver damage were significantly decreased in the NAFLD mouse model. The fat infiltration of the liver tissues of high-fat diet (HFD)-fed mice after betaine administration was significantly improved. Betaine treatment significantly upregulated AMP-activated protein kinase (AMPK), fibroblast growth factor 10 (FGF10), and adipose triglyceride lipase (ATGL) protein levels both in vivo and in vitro and suppressed lipid metabolism-related genes. Furthermore, the overexpression of FGF10 increased the protein level of AMPK and decreased lipid accumulation in HepG2 cells. CONCLUSION:Taken together, the data strongly suggest that betaine significantly prevents high-fat diet-induced NAFLD through the FGF10/AMPK signaling pathway in ApoE-/- mice.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Chen W,Zhang X,Xu M,Jiang L,Zhou M,Liu W,Chen Z,Wang Y,Zou Q,Wang Ldoi
10.1007/s00394-020-02362-6subject
Has Abstractpub_date
2020-08-17 00:00:00eissn
1436-6207issn
1436-6215pii
10.1007/s00394-020-02362-6pub_type
杂志文章abstract：BACKGROUND:Dietary polyphenols have been reported to have a variety of biological actions, including anticarcinogenic and antioxidant activities. AIM OF THE STUDY:In the present study we investigated the protective effect of dietary polyphenols against N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR) and ben...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-008-0751-6
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...
journal_title：European journal of nutrition
pub_type： 杂志文章,多中心研究
doi：10.1007/s00394-012-0473-7
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:Sesamin, a polyphenolic compound found in sesame seeds, has been reported to exert a variety of beneficial health effects. We have previously reported that sesamin increases the lifespan of Caenorhabditis elegans. In this study, we investigated the molecular mechanisms underlying the longevity effect of sesamin...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1396-0
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:Green tea is thought to possess many beneficial effects on human health. However, the extent of green tea polyphenol biotransformation may affect its proposed therapeutic effects. Catechol-O-methyltransferase (COMT), the enzyme responsible for polyphenolic methylation, has a common polymorphism in the genetic c...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章
doi：10.1007/s00394-011-0189-0
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1687-0
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:To investigate whether a low meat content of complementary food as accepted by EU law increases the risk of well-nourished infants to develop iron deficiency during the complementary feeding period. METHODS:Term born, healthy infants were randomized into a 'High Meat' Group (HM, n = 48) receiving commercial...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0043-9
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify metabolomic signatures re...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02177-5
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Low birth weight (LBW) associates with increased risk of developing type 2 diabetes. LBW individuals exhibit disproportionately reduced peripheral insulin action and increased fat oxidation after a 5-day high-fat overfeeding (HFO) challenge. Furthermore, LBW men exhibit increased nocturnal fat oxidation duri...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-015-1018-7
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:Increasing evidence suggests the potential use of natural antioxidant compounds in the prevention/treatment of osteoporosis. This study was undertaken to investigate the effects of purified delphinidin-3-rutinoside (D3R), isolated from Solanum melongena L., on osteoblast viability and differentiation in basal c...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1618-0
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Deficiency of micronutrients is common in refugee populations. OBJECTIVES:Identify deficiencies and whether provided supplements and wheat flour fortified with 10 micronutrients impacts upon status among breast-feeding women from Maela refugee camp. METHODS:Two sequential cross-sectional studies were condu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0226-z
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Disease preventing effects gained by garlic consumption have been recognized since early period of history, making commercially available garlic supplements attractive to the general public. Possible pharmacokinetic interactions which could occur between applied drugs and aged garlic extract (AGE) are unknow...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-010-0095-x
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Vegetables and fruits are rich sources of a variety of nutrients, including vitamins (E and C), trace minerals, and dietary fibers, and many other classes of biologically active compounds such as carotenoids and polyphenols, which are often assumed to protect against degenerative pathologies such as cardiova...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-006-0594-y
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:Cordyceps sinensis has been regarded as a precious tonic food and herbal medicine in China for thousands of years. The exopolysaccharide (EPS) from an anamorph of Cordyceps sinensis was found to have antitumor immunomodulatory activity. Mature dendritic cells play a role in initiating antitumor immunity, so we ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-012-0373-x
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). METHODS:We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,0...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02159-2
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Little is known about the effects of leptin and leptin receptor polymorphisms on lipid changes during pregnancy. The aims of this study were to evaluate the associations between the single nucleotide polymorphisms (SNPs) of leptin and leptin receptor genes and the lipid concentrations during pregnancy; and to t...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02049-7
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Experimentally imposed dietary restriction is known to extend the lifespan of rodents, perhaps by slowing the accumulation of oxidative damage that is thought to be one of the causes of aging. AIM OF THE STUDY:We examined the effects of restricted total food intake, and protein and calorie restriction, on D...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-004-0520-0
更新日期：2005-08-01 00:00:00
abstract：PURPOSE:The aims of this study were to evaluate the antihypertensive effectiveness of different doses of grape seed polyphenols in cafeteria diet-fed hypertensive rats (CHRs) and to establish the mechanism involved in the blood pressure (BP) lowering effect of these compounds in this experimental model of metabolic syn...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0895-0
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:Daily exposure to stress and excessive fructose intake coincides with the growing rate of obesity and related disorders, to which women are more prone than men. Glucocorticoids, the main regulators of energy balance and response to stress, have been associated with the development of metabolic disturbances. The...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-016-1251-8
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:The French Nutri-Bébé 2013 study aimed to assess the nutritional intake of infants and young children in comparison with the recommendations of the 2013 European Food Safety Authority (EFSA). METHODS:This cross-sectional study enrolled a random sample of families selected according to the Quota sampling method...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1883-y
更新日期：2020-02-01 00:00:00
abstract：PURPOSE:The associations between specific carotenoid intake and colorectal cancer risk remain inconsistent. The aim of this study was to examine the association between specific dietary carotenoid intake with colorectal cancer risk in Chinese adults. METHOD:From July 2010 to October 2013, 845 eligible colorectal cance...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0743-7
更新日期：2015-06-01 00:00:00
abstract：: ...
journal_title：European journal of nutrition
pub_type： 信件
doi：10.1007/s00394-018-1700-7
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Conjugated linoleic acid (CLA) has received great attention in recent years because of its pleiotropic biological activities, but considerably fewer studies have been published addressing its role in serum lipids and atherosclerosis compared to other topics covered. AIMS OF THE STUDY:The aim of the present ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-007-0653-z
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer's disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. METHODS:We used summary statistics data for single-nucleotide polymorphisms associated with plasm...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02126-x
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Uroguanylin (UGN) is a 16 amino acid peptide produced mainly by intestinal epithelial cells. Nutrients intake increases circulating levels of prouroguanylin that is processed and converted to UGN to activate the guanylyl cyclase 2C receptor (GUCY2C). Given that the UGN-GUCY2C system has been proposed as a novel...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0869-2
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Docosahexaenoic (C22:6) and arachidonic acid (C20:4) are long-chain polyunsaturated fatty acids (LC-PUFA), essential to fetal development, and preferentially transported by plasma phospholipids. OBJECTIVE:To characterize fetal and maternal plasma phospholipid changes during gestation, and to investigate whe...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1036-5
更新日期：2016-10-01 00:00:00
abstract：:Nutrition trends in Europe are driven by taste, health and convenience. The possibilities of research using new technologies and tools such as nutrigenomics, imaging techniques, nanotechnology, bioinformatics, cognitive sciences, innovative processes are very promising to support these nutrition trends and in particul...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-009-0076-0
更新日期：2009-12-01 00:00:00
abstract：BACKGOUND:Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE:To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postpr...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-018-1612-6
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:We examined whether high doses of folic acid and iron supplementation in early-to-mid pregnancy affect the risk of preterm birth, low birth weight, and small for gestational age neonates, in the mother-child cohort in Crete, Greece (Rhea study). METHODS:We included 1,279 women with singleton pregnancies with c...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-012-0339-z
更新日期：2013-02-01 00:00:00
abstract：AIM OF THIS STUDY:was to assess the validity of a 3-day estimated dietary record, especially developed for the longitudinal study on nutrition and health status in an aging population (aged > or = 60 years) in Giessen, Germany. METHODS:The dietary record comprises 146 food items. Portion sizes of the foods consumed we...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s003940050066
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:To compare the glycaemic response of whole grain oat kernels and pearled oats cooked under normal pressure or higher pressure and examine whether replacing half of the rice in a given meal with either of the two oat grains could make a difference in acute glycaemic responses. METHODS:In a randomised crossover ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02083-5
更新日期：2020-09-01 00:00:00
