Abstract:
BACKGROUND:Vitamins A, E and C, and uric acid, which can scavenge free radicals should also protect DNA from the damage. It is reasonable to assume that agents that decrease oxidative DNA damage should also decrease subsequent cancer development. AIM OF THE STUDY:A relationship between basal level of antioxidants (vitamins A, C and E and uric acid) and oxidative DNA damage was assessed. For the first time, the broad spectrum of oxidative DNA damage biomarkers: urinary excretion of 8-oxodG, 8-oxoGua and 5HMUra as well as the level of oxidative DNA damage in leukocytes was analyzed in healthy subjects (n = 158). METHODS:Using HPLC prepurification/isotope dilution GC/MS methodology, we examined the amount of oxidative DNA damage products excreted into urine and the amount of 8-oxodG in leukocytes' DNA (with HPLC/EC technique). The level of antioxidant vitamins and uric acid was estimated by HPLC technique with fluorimetric and UV detection. RESULTS:Analyses of relationship between the most common antioxidants (vitamins A, C, E and uric acid) and oxidative DNA damage products reveal weak, statistically significant negative correlation between retinol and all the measured parameters except 5HMUra. Vitamin C negatively correlates with urinary excretion of 8-oxodG and 8-oxoGua. Uric acid revealed statistically significant negative correlation with 8-oxodG in cellular DNA and urinary excretion of 5HMUra, while alpha-tocopherol correlates negatively only with 8-oxodG in cellular DNA. Good, significant (P < 0.0001), positive correlation (r = 0.61) was noted between urinary levels of the base, 8-oxoGua and the deoxynucleoside, 8-oxodG. CONCLUSION:Our results suggest that oxidative DNA damage shows limited but significant response to antioxidants analyzed in this study and is more affected by many other cellular functions like antioxidant enzymes or DNA repair enzymes as well as genetics.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Foksinski M,Gackowski D,Rozalski R,Siomek A,Guz J,Szpila A,Dziaman T,Olinski Rdoi
10.1007/s00394-006-0642-7subject
Has Abstractpub_date
2007-04-01 00:00:00pages
174-80issue
3eissn
1436-6207issn
1436-6215journal_volume
46pub_type
杂志文章abstract:PURPOSE:The aim was to compare the anthropometric and metabolic profiles and lifestyle behaviours of yogurt consumers and non-consumers and to determine if the observed differences persisted after adjustment for diet quality and related variables. METHODS:Using cross-sectional and follow-up data from the Québec Family...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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abstract:: ...
journal_title:European journal of nutrition
pub_type: 信件
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of nutrition
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更新日期:2012-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-019-02159-2
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of nutrition
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更新日期:2017-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:European journal of nutrition
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更新日期:2020-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1532-x
更新日期:2018-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0412-7
更新日期:2013-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-012-0358-9
更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-11-04 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1004-0
更新日期:2016-08-01 00:00:00