Abstract:
BACKGROUND:At the present time the recommended daily intake or allowance (RDA) and the safe upper level (UL) of intake of micronutrients are given as single values. The recommended daily intake is considered to cover the requirements of 97.5% of the population while the safe upper level is a value for the whole population. These values provide only limited guidance to risk managers. AIM OF THE STUDY AND METHODS:A method has been developed recently which models the relationships between intake and risks of either deficiency or excess using an observed incidence for each effect and population distribution characteristics. Using this model it is possible to formulate advice to risk managers on the incidence (prevalence) of adverse effects, due to either deficiency or excess, at different levels of intake. Application of the model to the data used to derive the RDA and UL for selenium shows that it can predict the impact of changes in nutrient intake on the balance between benefit (absence of deficiency) and risk (development of toxicity). RESULTS AND CONCLUSIONS:Application of the model has illustrated the utility of this approach, but highlighted the need for a comprehensive evaluation of the data and a critical appraisal of the validity of the relationships that are analyzed. In addition, the derived incidences will usually relate to effects with different biological or health impacts, so that the final balance between benefit and risk should be developed by a dialogue between the risk assessor and the risk manager.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Renwick AG,Dragsted LO,Fletcher RJ,Flynn A,Scott JM,Tuijtelaars S,Wildemann Tdoi
10.1007/s00394-007-0691-6subject
Has Abstractpub_date
2008-02-01 00:00:00pages
17-25issue
1eissn
1436-6207issn
1436-6215journal_volume
47pub_type
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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更新日期:2018-04-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-018-1813-z
更新日期:2019-10-01 00:00:00
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journal_title:European journal of nutrition
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更新日期:2008-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-08-01 00:00:00
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更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Accumulating evidence suggests that inhibitors of aldose reductase (AR) may prevent hyperglycemia-induced long-term complications in diabetes mellitus. In the present study, we evaluated the AR inhibitory potential of ethanolic (EtOH) extracts from 22 seaweed species. METHODS:AR inhibitory activities of the se...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0521-y
更新日期:2014-02-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-003-0390-x
更新日期:2003-04-01 00:00:00
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doi:10.1007/s00394-012-0358-9
更新日期:2013-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1101-0
更新日期:2017-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1866-z
更新日期:2019-12-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1149-x
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin-angiotensin-aldosterone system, in healthy humans. METHODS:A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingest...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-015-1110-z
更新日期:2017-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-018-1695-0
更新日期:2018-12-01 00:00:00
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更新日期:2006-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1713-2
更新日期:2019-03-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-1098-4
更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
abstract:PURPOSE:Pomegranate fruit, Punica granatum L. (Punicaceae), and its constituents have been shown to inhibit inflammation. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. METHODS:An enzyme immunoassay (EIA) was used to measure prostag...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
abstract::The objective of this study was to assess the effect of conjugated linoleic acid isomers (CLAs) on the expression and activity of phospholipases A(2) (PLA(2)) in human macrophages. Macrophages were incubated with 30 microM cis-9, trans-11 and trans-10, cis-12 CLAs for 48 h. After incubation, the total activity of phos...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-006-0626-7
更新日期:2007-02-01 00:00:00
abstract:PURPOSE:To get insight in the impact of fish and fat intake in the prevention of accelerated cognitive decline with ageing, we tested associations between fish and different fat intakes and 5-year change in cognitive functions. METHODS:In 2612 men and women of the Doetinchem Cohort Study, aged 43-70 years at baseline,...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1453-8
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption an...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02295-0
更新日期:2020-06-10 00:00:00
abstract:PURPOSE:Although a role of glycemic index (GI) and glycemic load (GL) in age-related cataract development is plausible, a few studies, all conducted in USA or Australia, provided results on this issue. The aim of the present study was to provide new original data from a Mediterranean population. METHODS:We analyzed da...
journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
doi:10.1007/s00394-014-0731-y
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:No previous study has examined the associations between egg consumption and prevalence of psychological disorders. The present study was conducted to determine the association between egg consumption and depression in a large sample of Iranian adults. METHODS:This cross-sectional study was conducted on 3172 ad...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00