Abstract:
BACKGROUND:Extensive exercise may promote the formation of reactive oxygen species and subsequently contribute to tissue damage. A compound which can protect cells and tissues is vitamin E. The vitamin E radical, formed during the radical scavenging process, can be reduced by vitamin C resulting in a higher level of the vitamin C radical (semidehydroascorbate free radical). An increase of the vitamin C radical, however, is assumed to exert prooxidative effects. AIM OF THE STUDY:To elucidate whether supplementation of vitamin E and exhaustive exercise lead to an increase of the vitamin C radical in human plasma. METHODS:A placebo controlled, cross over study with 13 male volunteers was carried out. After an 8 day supplementation period with 500 I.U. D-alpha-tocopherol, the subjects performed two exhaustive treadmill runs. Blood samples were collected at rest, 0, 0.25, 1, 3, 24 and 48 h after exercise. Serum was separated and concentrations of D-alpha-tocopherol and ascorbic acid were determined by HPLC. Vitamin C radical levels in plasma were assessed by electron paramagnetic resonance (EPR). RESULTS:Vitamin E and C both showed a tendency to decrease between 3 h and 24 h after exercise. Vitamin C radical level remained stable during the whole period. Neither vitamin E supplementation nor exercise had any influence on the plasma concentration of the vitamin C radical. CONCLUSIONS:Vitamin E supplementation under conditions of mild oxidative stress does not result in an increased vitamin C radical concentration.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Schneider M,Niess AM,Rozario F,Angres C,Tschositsch K,Golly I,Battenfeld N,Schäffer M,Northoff H,Dickhuth HH,Fehrenbach E,Trommer WE,Biesalski HKdoi
10.1007/s00394-003-0414-6keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
195-200issue
4eissn
1436-6207issn
1436-6215journal_volume
42pub_type
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