Abstract：
PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher concentrations of two acylcarnitines and lower levels of three amino acids, six acyl-alkyl phosphatidylcholines, and three lysophosphatidylcholines. The aim of this study was to analyze whether these alterations normalize in weight loss. METHODS:We analyzed the changes of these 14 metabolites by the same metabolic kit as in our previous study in serum samples of 80 obese children with substantial weight loss (BMI-SDS reduction >0.5) and in 80 obese children with stable weight status all participating in a 1-year lifestyle intervention. RESULTS:In the children without weight change, no significant changes of metabolite concentrations could be observed. In children with substantial weight loss, glutamine, methionine, the lysophosphatidylcholines LPCaC18:1, LPCaC18:2, and LPCa20:4, as well as the acyl-alkyl phosphatidylcholine PCaeC36:2 increased significantly, while the acylcarnitines C12:1 and C16:1, proline, PCaeC34:1, PCaeC34:2, PCaeC34:3, PCaeC36:3, and PCaeC38:2 did not change significantly. CONCLUSIONS:The changes of glutamine, methionine, LPCaC18:1, LPCaC18:2, LPCa20:4, and PCaeC36:2 seem to be related to the changes of dieting or exercise habits in lifestyle intervention or to be a consequence of overweight since they normalized in weight loss. Further studies should substantiate our findings.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Reinehr T,Wolters B,Knop C,Lass N,Hellmuth C,Harder U,Peissner W,Wahl S,Grallert H,Adamski J,Illig T,Prehn C,Yu Z,Wang-Sattler R,Koletzko Bdoi
10.1007/s00394-014-0698-8subject
Has Abstractpub_date
2015-03-01 00:00:00pages
173-81issue
2eissn
1436-6207issn
1436-6215journal_volume
54pub_type
杂志文章abstract：BACKGROUND:Vitamins A, E and C, and uric acid, which can scavenge free radicals should also protect DNA from the damage. It is reasonable to assume that agents that decrease oxidative DNA damage should also decrease subsequent cancer development. AIM OF THE STUDY:A relationship between basal level of antioxidants (vit...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-006-0642-7
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Glutathione peroxidase 1 (GPx1) is an antioxidant selenoenzyme that protects the cells against reactive oxygen species. Its activity depends on the concentration of selenium (Se) which is present in the active centre of the enzyme. The genetic polymorphism of GPx1 encoding gene (GPx1) associated with the pro...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-009-0023-0
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:To investigate whether a low meat content of complementary food as accepted by EU law increases the risk of well-nourished infants to develop iron deficiency during the complementary feeding period. METHODS:Term born, healthy infants were randomized into a 'High Meat' Group (HM, n = 48) receiving commercial...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0043-9
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Flavonoids have physiological activity and a variety of pharmacological properties, including anticancer activity in vitro, but structure-anticancer activity relationships are unclear. AIM:The objectives of this work were to investigate the activity of dietary flavonol congeners against cell lines derived f...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0204-5
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:Protein-restricted diet during pregnancy is related to oxidative stress and, as a consequence, damage to nephrogenesis. We investigated the effects of vinifera grape skin extract (ACH09)-derived polyphenols on preserving renal morphology of maternal protein-restricted 1-day-old offspring. METHODS:Female C57/Bl...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0963-5
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:Advanced glycation endproducts (AGEs) are produced endogenously and also enter the body during the consumption of AGEs present in heat-processed food. It is unknown whether AGEs of dietary origin accumulate within the body of healthy individuals. AGEs can deposit within skin tissue long-term by crosslinking ext...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1495-y
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption an...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02295-0
更新日期：2020-06-10 00:00:00
abstract：PURPOSE:Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Our aim was to investigate the effect of the dietary fat on the two main adipose tissue functions, endocrine and lipid store, by analyzing the adipose tissue gene expression from metabolic syndrome patients. METHODS:A randomized...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-013-0570-2
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:There is considerable variation in incremental circulating 25-hydroxyvitamin D (25OHD) levels on vitamin D supplements, even when similar age groups and identical vitamin D doses are compared. We therefore aimed to investigate the importance of body weight for the dose-response relation in circulating 25OHD. M...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-013-0634-3
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Rooibos tea (Aspalathus linearis) is commonly used for hyperactive gastrointestinal, respiratory and cardiovascular disorders. AIM OF STUDY:The aqueous extract of Rooibos tea (RT) was studied for the possible bronchodilator, antispasmodic and blood pressure lowering activities in an attempt to rationalize s...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-006-0620-0
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:The French Nutri-Bébé 2013 study aimed to assess the nutritional intake of infants and young children in comparison with the recommendations of the 2013 European Food Safety Authority (EFSA). METHODS:This cross-sectional study enrolled a random sample of families selected according to the Quota sampling method...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1883-y
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Fruits and nuts may prevent or reverse common human health conditions such as obesity, diabetes and hypertension; together, these conditions are referred to as metabolic syndrome, an increasing problem. This study has investigated the responses to ellagic acid, present in many fruits and nuts, in a diet-indu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-012-0358-9
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Lutein is a carotenoid that may play a role in eye health. Human milk typically contains higher concentrations of lutein than infant formula. Preliminary data suggest there are differences in serum lutein concentrations between breastfed and formula-fed infants. AIM OF THE STUDY:To measure the serum lutein ...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0047-5
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:The antiatherogenic activity of pomegranate juice has been attributed to its antioxidant polyphenols. The most potent in vitro antioxidant polyphenol from this juice is the ellagitannin punicalagin. However, the bioavailability of ellagitannins, including punicalagin, has not been previously described in hum...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-004-0461-7
更新日期：2004-08-01 00:00:00
abstract：PURPOSE:Recent epidemiological studies have shown that habitual consumption of extra virgin olive oil (EVOO), the characteristic culinary fat of the Mediterranean area, is effective in the prevention of diverse types of digestive disorders such as inflammatory bowel disease. Many of these benefits are, in addition to i...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0235-y
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:Higher long-chain polyunsaturated fatty acids (LCP) in infant compared with maternal lipids at delivery is named biomagnification. The decline of infant and maternal docosahexaenoic acid (DHA) status during lactation in Western countries suggests maternal depletion. We investigated whether biomagnification pers...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0245-9
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Conifer seeds are used for food preparation in several countries. Aim of the study To assess the lipid-lowering and antiatherogenic properties of maritime pine (Pinuspinaster) seed oil. METHODS:The effects of maritime pine oil supplementation (20% w/w) for 2 weeks were compared to those of coconut and sunfl...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s394-001-8355-6
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Neurodevelopmental effects of omega-3 fatty acids and mercury from fish consumption have been characterized in children. In contrast, neurobehavioral outcomes associated with fish are not well studied in adults. OBJECTIVE:This study of avid seafood consumers on Long Island (NY, USA) sought to define associa...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0890-5
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To assess the effectiveness of a dietary intervention combined with fortified dairy products on bone metabolism and bone mass indices in postmenopausal women. METHODS:Forty postmenopausal women (55-65 years old) were equally randomized into a dietary group (DG), receiving daily and for 30 months, 1,200 mg of c...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-010-0142-7
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose i...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1456-5
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Inulin has been suggested to have beneficial effects on lipids, especially on triglyceridemia. Few data are available about the effects of inulin on Lipoprotein(a), a low-density lipoprotein-like particle considered as an independent risk factor for atherosclerosis. Adding inulin to pasta could be a preventi...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-008-0748-1
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Iron deficiency in children is a major worldwide nutritional problem. An oat beverage was developed for 1- to 3-year-old children and different treatments were used to improve the iron bioavailability. AIM OF THE STUDY:To investigate the effects of citric acid addition, phytase treatment and supplementation...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-006-0637-4
更新日期：2007-03-01 00:00:00
abstract：:Low intracellular magnesium (Mg) contents may be observed in case of severe Mg insufficient intake or because of genetic regulation. This work was conducted to investigate the influence of intracellular Mg content on erythrocyte Mg(2+) influx and efflux in mice with low nutritionally and genetically (MGL and MGH mice)...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-005-0579-2
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:Critically low skeletal muscle mass and strength, observed in 20% of people with chronic heart failure (CHF), reduces functional capacity, quality of life (QoL) and survival. Protein and essential amino acid (EAA) supplementation could be a viable treatment strategy to prevent declines in muscle strength and pe...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-019-02108-z
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Globally, around 20 million children suffer from severe acute malnutrition (SAM). Identifying a more economical treatment for those affected has the potential to make treatment more available and improve prognosis for recovery and future health. DESIGN/METHODS:The double-blind randomized study...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-019-01975-w
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:The imbalance of n-6 and n-3 polyunsaturated fatty acids in the maternal diet impairs intestinal barrier development and sensitizes the colon response to inflammatory insults in the young rats. With a view to overcoming this issue, we designed this study to investigate the effect of maternal and neonatal int...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1004-0
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:Iodine deficiency affects 30% of populations worldwide. The amount of thyroglobulin (Tg) in blood increases in iodine deficiency and also in iodine excess. Tg is considered as a sensitive index of iodine status in groups of children and adults, but its usefulness for individuals is unknown. The aim of this stud...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1410-6
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Adherence to Mediterranean diet has been shown to be associated with a better health and greater survival. The aim of the present study was to identify change-points in the relationship between food groups composing Mediterranean diet and overall mortality. METHODS:The population of the Greek EPIC prospecti...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0202-7
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:Although a role of glycemic index (GI) and glycemic load (GL) in age-related cataract development is plausible, a few studies, all conducted in USA or Australia, provided results on this issue. The aim of the present study was to provide new original data from a Mediterranean population. METHODS:We analyzed da...
journal_title：European journal of nutrition
pub_type： 杂志文章,多中心研究
doi：10.1007/s00394-014-0731-y
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:To describe total fluid intake (TFI) and types of fluid consumed in urban China by age, gender, regions and city socioeconomic status relative to the adequate intakes (AI) set by the Chinese Nutrition Society. METHODS:In 2016, participants aged 4-9, 10-17 and 18-55 years were recruited via a door-to-door appro...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1755-5
更新日期：2018-06-01 00:00:00
