Abstract:
PURPOSE:Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Our aim was to investigate the effect of the dietary fat on the two main adipose tissue functions, endocrine and lipid store, by analyzing the adipose tissue gene expression from metabolic syndrome patients. METHODS:A randomized, controlled trial conducted within the LIPGENE study assigned 39 metabolic syndrome patients to 1 of 4 isoenergetic diets: (1) high-saturated fatty acid (HSFA), (2) high-monounsaturated fatty acid (HMUFA), (3) low-fat, high-complex carbohydrate diet supplemented with long-chain n-3 fatty acids (LFHCC n-3), and (4) low-fat, high-complex carbohydrate diet supplemented with placebo (LFHCC), for 12 weeks each. A fat challenge reflecting the fatty acid composition as the original diets was conducted post-intervention. RESULTS:The long-term consumption of HSFA, LFHCC, and LFHCC n-3 diets, but not HMUFA diet, decreased the perilipin fasting mRNA levels. LFHCC diet consumption increased fasting FABP4 expression, while it was reduced by the consumption of LFHCC n-3 diet. LFHCC meal reduced, while LFHCC n-3 meal intake increased postprandial CAV1 expression. CONCLUSION:The quantity and quality of dietary fat induce differential lipid storage and processing related gene expression, which may interact with the expression of adipokines through common regulatory mechanisms.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Camargo A,Meneses ME,Perez-Martinez P,Delgado-Lista J,Jimenez-Gomez Y,Cruz-Teno C,Tinahones FJ,Paniagua JA,Perez-Jimenez F,Roche HM,Malagon MM,Lopez-Miranda Jdoi
10.1007/s00394-013-0570-2subject
Has Abstractpub_date
2014-01-01 00:00:00pages
617-26issue
2eissn
1436-6207issn
1436-6215journal_volume
53pub_type
杂志文章,随机对照试验abstract:PURPOSE:Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its ...
journal_title:European journal of nutrition
pub_type: 杂志文章
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abstract:PURPOSE:To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. METHODS:In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. S...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of nutrition
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abstract:BACKGROUND:To investigate whether a low meat content of complementary food as accepted by EU law increases the risk of well-nourished infants to develop iron deficiency during the complementary feeding period. METHODS:Term born, healthy infants were randomized into a 'High Meat' Group (HM, n = 48) receiving commercial...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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abstract:PURPOSE:Heme iron may contribute to the development of atherosclerosis by catalyzing production of hydroxyl-free radicals and promoting low-density lipoprotein oxidation. However, epidemiologic findings regarding the association between heme iron intake and risk of coronary heart disease (CHD) are inconsistent. We aime...
journal_title:European journal of nutrition
pub_type: 杂志文章,meta分析
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abstract:BACKGROUND:Addition of capsaicin to the diet has been shown to increase satiety and thermogenesis. The effects of capsaicin on ghrelin, peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), in relation to changes in hunger and satiety are unknown. AIM:To test the acute effects of a lunch containing capsaicin on gut de...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:Docosahexaenoic (C22:6) and arachidonic acid (C20:4) are long-chain polyunsaturated fatty acids (LC-PUFA), essential to fetal development, and preferentially transported by plasma phospholipids. OBJECTIVE:To characterize fetal and maternal plasma phospholipid changes during gestation, and to investigate whe...
journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:European journal of nutrition
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
abstract::Carotenoids are important micronutrients in the human diet and are present in human serum at micromolar concentrations. In addition to their antioxidant potential, carotenoids obtain physiologically relevant properties such as influencing cellular signal pathways, gene expression or induction of detoxifying enzymes. I...
journal_title:European journal of nutrition
pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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更新日期:2004-12-01 00:00:00