当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NUTRITION期刊下所有文献 > Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial.

Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial.

Abstract：

PURPOSE:Observational studies have frequently reported that low blood folate concentrations are associated with poor cognitive performance. Our previous studies have shown the potential beneficial effect on the metabolite levels of methionine cycle and peripheral blood inflammatory cytokines from 6- and 12-month folic acid supplementation on cognitive function in mild cognitive impairment (MCI). This study aims to continue exploring the effect of 24-month folic acid supplementation on cognitive function and pathological mechanism in MCI. METHODS:180 individuals with MCI were identified and randomly divided into intervention (folic acid 400 µg/day, n = 90) and convention (n = 90) groups. Cognitive function (WAIS-RC) and blood Aβ-related biomarkers were measured at baseline and at 6, 12, 18, and 24 months. Data were analyzed using generalized estimating equation. This trial has been registered with Trial Number: ChiCTR-TRC-13003227. RESULTS:During the follow-up, scores of full scale IQ, verbal IQ, and subdomains of Information and Digit Span were significantly higher in the intervention group than those in the convention group (P < 0.05). In the intervention group, blood homocysteine, S-adenosylhomocysteine (SAH), Aβ-42, and the expression of APP-mRNA were decreased (P < 0.05), while S-adenosylmethionine (SAM), SAM/SAH ratio, and the expression of DNA methyltransferase mRNA were increased (P < 0.05). CONCLUSION:Folic acid supplementation appears to improve cognitive function and reduce blood levels of Aβ-related biomarkers in MCI. Larger-scale double-blind placebo-controlled randomized trials of longer duration are needed.

journal_name

Eur J Nutr

journal_title

European journal of nutrition

authors

Ma F,Li Q,Zhou X,Zhao J,Song A,Li W,Liu H,Xu W,Huang G

doi

10.1007/s00394-017-1598-5

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

345-356

issue

1

eissn

1436-6207

issn

1436-6215

pii

10.1007/s00394-017-1598-5

journal_volume

58

pub_type

杂志文章,随机对照试验

相关文献

EUROPEAN JOURNAL OF NUTRITION文献大全
  • Maternal diet, bioactive molecules, and exercising as reprogramming tools of metabolic programming.

    abstract：:Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases. Nutrition is likely the most important environmental factor that modulates the expression of genes involved in metabolic pathways and a variety of phenotypes associated...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,评审

    doi：10.1007/s00394-014-0654-7

    authors： Mathias PC,Elmhiri G,de Oliveira JC,Delayre-Orthez C,Barella LF,Tófolo LP,Fabricio GS,Chango A,Abdennebi-Najar L

    更新日期：2014-04-01 00:00:00

  • Calcium and zinc decrease intracellular iron by decreasing transport during iron repletion in an in vitro model.

    abstract：PURPOSE:Iron is an essential micronutrient that participates in a number of vital reactions and its absorption may be altered by various nutritional factors such as other micronutrients. Our hypothesis is that iron absorption is decreased because of the interactions with zinc and calcium. We evaluated the interaction b...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-017-1535-7

    authors： Mónica A,Lautaro B,Fernando P,Miguel A

    更新日期：2018-12-01 00:00:00

  • Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans.

    abstract：PURPOSE:Sesamin, a polyphenolic compound found in sesame seeds, has been reported to exert a variety of beneficial health effects. We have previously reported that sesamin increases the lifespan of Caenorhabditis elegans. In this study, we investigated the molecular mechanisms underlying the longevity effect of sesamin...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-017-1396-0

    authors： Nakatani Y,Yaguchi Y,Komura T,Nakadai M,Terao K,Kage-Nakadai E,Nishikawa Y

    更新日期：2018-04-01 00:00:00

  • In vitro activity of dietary flavonol congeners against human cancer cell lines.

    abstract：BACKGROUND:Flavonoids have physiological activity and a variety of pharmacological properties, including anticancer activity in vitro, but structure-anticancer activity relationships are unclear. AIM:The objectives of this work were to investigate the activity of dietary flavonol congeners against cell lines derived f...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-011-0204-5

    authors： Tsimplouli C,Demetzos C,Hadzopoulou-Cladaras M,Pantazis P,Dimas K

    更新日期：2012-03-01 00:00:00

  • A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial.

    abstract：PURPOSE:To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. METHODS:In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. S...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-015-0859-4

    authors： Yao P,Lu L,Hu Y,Liu G,Chen X,Sun L,Ye X,Zheng H,Chen Y,Hu FB,Li H,Lin X

    更新日期：2016-02-01 00:00:00

  • Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity.

    abstract：PURPOSE:Aim of this study was to identify a possible relationship among dietary fatty acids (FA) intake, FA adipose tissue (AT) profile and cancer condition in lean vs obese subjects affected or not by colorectal cancer (CRC). Actually, inadequate dietary habits together with physical inactivity are primary determinant...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02003-7

    authors： Scazzocchio B,Varì R,Silenzi A,Giammarioli S,Masotti A,Baldassarre A,Santangelo C,D'Archivio M,Giovannini C,Del Cornò M,Conti L,Gessani S,Masella R

    更新日期：2020-06-01 00:00:00

  • Minimising the population risk of micronutrient deficiency and over-consumption: a new approach using selenium as an example.

    abstract：BACKGROUND:At the present time the recommended daily intake or allowance (RDA) and the safe upper level (UL) of intake of micronutrients are given as single values. The recommended daily intake is considered to cover the requirements of 97.5% of the population while the safe upper level is a value for the whole populat...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-007-0691-6

    authors： Renwick AG,Dragsted LO,Fletcher RJ,Flynn A,Scott JM,Tuijtelaars S,Wildemann T

    更新日期：2008-02-01 00:00:00

  • Put "gender glasses" on the effects of phenolic compounds on cardiovascular function and diseases.

    abstract：INTRODUCTION:The influence of sex and gender is particularly relevant in cardiovascular diseases (CVD) as well as in several aspects of drug pharmacodynamics and pharmacokinetics. Anatomical and physiological differences between the sexes may influence the activity of many drugs, including the possibility of their inte...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,评审

    doi：10.1007/s00394-018-1695-0

    authors： Campesi I,Marino M,Cipolletti M,Romani A,Franconi F

    更新日期：2018-12-01 00:00:00

  • Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study.

    abstract：:The original version of this article unfortunately contained a mistake. José M. Gámez was not listed among the authors. ...

    journal_title：European journal of nutrition

    pub_type： 已发布勘误

    doi：10.1007/s00394-020-02433-8

    authors： Navarrete-Muñoz EM,Vioque J,Toledo E,Oncina-Canovas A,Martínez-González MÁ,Salas-Salvadó J,Corella D,Fitó M,Romaguera D,Alonso-Gómez ÁM,Wärnberg J,Martínez JA,Serra-Majem L,Estruch R,Tinahones FJ,Lapetra J,Pintó X,Tur J

    更新日期：2020-12-05 00:00:00

  • Emerging technologies and perspectives for nutrition research in European Union 7th Framework Programme.

    abstract：:Nutrition trends in Europe are driven by taste, health and convenience. The possibilities of research using new technologies and tools such as nutrigenomics, imaging techniques, nanotechnology, bioinformatics, cognitive sciences, innovative processes are very promising to support these nutrition trends and in particul...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-009-0076-0

    authors： de Froidmont-Görtz IB

    更新日期：2009-12-01 00:00:00

  • Dietary polyphenols protect against N-nitrosamines and benzo(a)pyrene-induced DNA damage (strand breaks and oxidized purines/pyrimidines) in HepG2 human hepatoma cells.

    abstract：BACKGROUND:Dietary polyphenols have been reported to have a variety of biological actions, including anticarcinogenic and antioxidant activities. AIM OF THE STUDY:In the present study we investigated the protective effect of dietary polyphenols against N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR) and ben...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-008-0751-6

    authors： Delgado ME,Haza AI,Arranz N,García A,Morales P

    更新日期：2008-12-01 00:00:00

  • Adherence to the DASH diet and prevalence of the metabolic syndrome among Iranian women.

    abstract：PURPOSE:Epidemiologic data linking adherence to the dietary approaches to stop hypertension (DASH) diet and metabolic abnormalities is sparse and inconsistent. The association between habitual intake of the DASH diet and metabolic syndrome (MetS) has not been investigated in the Middle East. We aimed to determine wheth...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-014-0723-y

    authors： Saneei P,Fallahi E,Barak F,Ghasemifard N,Keshteli AH,Yazdannik AR,Esmaillzadeh A

    更新日期：2015-04-01 00:00:00

  • A lavatory urine color (LUC) chart method can identify hypohydration in a physically active population.

    abstract：PURPOSE:To provide a new and efficient at-the-toilet-bowl method of self-assessing urine concentration via urine color (Uc) to identify hypohydration. METHODS:A large athletic population (n = 189) delivered a urine sample, then chose a color panel that was displayed on the back wall of the lavatory stall. Selection wa...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-020-02460-5

    authors： Wardenaar FC,Thompsett D,Vento KA,Bacalzo D

    更新日期：2021-01-08 00:00:00

  • Dietary factors associated with metabolic risk score in Finnish children aged 6-8 years: the PANIC study.

    abstract：PURPOSE:Previous evidence for the associations of eating frequency and food consumption with clustering of metabolic risk factors among children is limited. We therefore investigated association of the daily number of main meals and snacks and food consumption with a metabolic risk score and individual metabolic risk f...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-013-0646-z

    authors： Eloranta AM,Lindi V,Schwab U,Kiiskinen S,Venäläinen T,Lakka HM,Laaksonen DE,Lakka TA

    更新日期：2014-09-01 00:00:00

  • N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis.

    abstract：PURPOSE:The objective of the present study was to test the hypothesis that N-acetylcysteine (NAC) may play beneficial roles against intrauterine growth retardation (IUGR)-induced hepatic damage in suckling piglets. METHODS:Fourteen IUGR and seven normal birth weight (NBW) neonatal male piglets were selected. Piglets w...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-016-1322-x

    authors： Zhang H,Su W,Ying Z,Chen Y,Zhou L,Li Y,Zhang J,Zhang L,Wang T

    更新日期：2018-02-01 00:00:00

  • Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model.

    abstract：PURPOSE:Recent epidemiological studies have shown that habitual consumption of extra virgin olive oil (EVOO), the characteristic culinary fat of the Mediterranean area, is effective in the prevention of diverse types of digestive disorders such as inflammatory bowel disease. Many of these benefits are, in addition to i...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-011-0235-y

    authors： Sánchez-Fidalgo S,Sánchez de Ibargüen L,Cárdeno A,Alarcón de la Lastra C

    更新日期：2012-06-01 00:00:00

  • Garlic metabolites fail to inhibit the activation of the transcription factor NF-kappaB and subsequent expression of the adhesion molecule E-selectin in human endothelial cells.

    abstract：BACKGROUND:The transcription factor NF-kappaB is suggested to play a pivotal role in atherogenesis by regulating the expression of proinflammatory gene products such as adhesion molecules. Garlic is consumed as food or dietary supplement in order to benefit from its antiatherogenic effect. AIM OF THE STUDY:This study ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-004-0437-7

    authors： Dirsch VM,Keiss HP,Vollmar AM

    更新日期：2004-02-01 00:00:00

  • Complementary food with low (8%) or high (12%) meat content as source of dietary iron: a double-blinded randomized controlled trial.

    abstract：BACKGROUND:To investigate whether a low meat content of complementary food as accepted by EU law increases the risk of well-nourished infants to develop iron deficiency during the complementary feeding period. METHODS:Term born, healthy infants were randomized into a 'High Meat' Group (HM, n = 48) receiving commercial...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-009-0043-9

    authors： Dube K,Schwartz J,Mueller MJ,Kalhoff H,Kersting M

    更新日期：2010-02-01 00:00:00

  • Vitamin D deficiency and hyperparathyroidism in relation to ethnicity: a cross-sectional survey in healthy adults.

    abstract：BACKGROUND:The study of vitamin D status at population level gained relevance since vitamin D deficiency was recently suggested to trigger chronic disease. AIM OF THE STUDY:We aimed to describe vitamin D status, its association with bone and mineral metabolism and risk factors for deficiency in adults over 40 years in...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-008-0756-1

    authors： Moreno-Reyes R,Carpentier YA,Boelaert M,El Moumni K,Dufourny G,Bazelmans C,Levêque A,Gervy C,Goldman S

    更新日期：2009-02-01 00:00:00

  • Association between n-3 polyunsaturated fatty acids in erythrocytes and metabolic syndrome in Chinese men and women.

    abstract：PURPOSE:Evidence of an association between n-3 polyunsaturated fatty acids (PUFAs) and metabolic syndrome (MS) is limited and inconsistent. We investigated the association between n-3 PUFAs in erythrocytes and the presence of MS in Chinese adults. METHODS:The levels of α-linolenic acid (ALA), eicosapentaenoic acid (EP...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0912-3

    authors： Dai XW,Chen YM,Zeng FF,Sun LL,Chen CG,Su YX

    更新日期：2016-04-01 00:00:00

  • 100% Fruit juice intake and cardiovascular risk: a systematic review and meta-analysis of prospective and randomised controlled studies.

    abstract：PURPOSE:The relationship between 100% fruit juice (100%FJ) consumption and cardiovascular risk is object of debate: indeed, recently published investigations provided new but discrepant evidence on this important question and International dietary guidelines are not in agreement on recommendations about fruit juice con...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-020-02426-7

    authors： D'Elia L,Dinu M,Sofi F,Volpe M,Strazzullo P,SINU Working Group, Endorsed by SIPREC.

    更新日期：2020-11-04 00:00:00

  • Association between leukocyte telomere length and serum carotenoid in US adults.

    abstract：PURPOSE:Telomere length is a biomarker for aging. It is known that oxidative stress can accelerate telomere shortening, whereas antioxidants can delay their shortening. Carotenoids as antioxidants are favorably associated with health- and aging-related diseases caused by oxidative stress, but their association with tel...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-016-1152-x

    authors： Min KB,Min JY

    更新日期：2017-04-01 00:00:00

  • Independent associations of vitamin D metabolites with anemia in patients referred to coronary angiography: the LURIC study.

    abstract：PURPOSE:Anemia and vitamin D deficiency are both frequent in adult patients. Whether low vitamin D metabolite levels are an independent risk factor for different subtypes of anemia remains to be studied in detail. METHODS:In 3299 patients referred for coronary angiography, we investigated the association of 25-hydroxy...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-1149-x

    authors： Ernst JB,Zittermann A,Pilz S,Kleber ME,Scharnagl H,Brandenburg VM,König W,Grammer TB,März W

    更新日期：2017-04-01 00:00:00

  • Multinational study of major breast milk carotenoids of healthy mothers.

    abstract：BACKGROUND:Carotenoids in serum vary between countries and within populations with evidence suggesting a qualitative relationship to diet. Breast milk carotenoids furnish a source of vitamin A and potentially provide immunoprotection and other health benefits for infants. There have been numerous studies of milk carote...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-003-0403-9

    authors： Canfield LM,Clandinin MT,Davies DP,Fernandez MC,Jackson J,Hawkes J,Goldman WJ,Pramuk K,Reyes H,Sablan B,Sonobe T,Bo X

    更新日期：2003-06-01 00:00:00

  • Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, beta-glucan: a dose response study in obese women with increased risk for insulin resistance.

    abstract：BACKGROUND:A high intake of whole grains containing soluble fiber has been shown to lower glucose and insulin responses in overweight humans and humans with type 2 diabetes. AIM OF THE STUDY:We investigated the linearity of this response after consumption of 5 breakfast cereal test meals containing wheat and/or barley...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-009-0778-3

    authors： Kim H,Stote KS,Behall KM,Spears K,Vinyard B,Conway JM

    更新日期：2009-04-01 00:00:00

  • Vitamin D supplementation, body weight and human serum 25-hydroxyvitamin D response: a systematic review.

    abstract：PURPOSE:There is considerable variation in incremental circulating 25-hydroxyvitamin D (25OHD) levels on vitamin D supplements, even when similar age groups and identical vitamin D doses are compared. We therefore aimed to investigate the importance of body weight for the dose-response relation in circulating 25OHD. M...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,评审

    doi：10.1007/s00394-013-0634-3

    authors： Zittermann A,Ernst JB,Gummert JF,Börgermann J

    更新日期：2014-01-01 00:00:00

  • Disparate metabolic effects of blackcurrant seed oil in rats fed a basal and obesogenic diet.

    abstract：PURPOSE:It was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine. METHODS:Male Wistar rats were randomly assigned to four groups o...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-014-0775-z

    authors： Jurgoński A,Fotschki B,Juśkiewicz J

    更新日期：2015-09-01 00:00:00

  • Longitudinal changes in body weight and body composition among women previously treated for breast cancer consuming a high-vegetable, fruit and fiber, low-fat diet.

    abstract：BACKGROUND:Excess adiposity has been shown to be associated with increased risk for breast cancer recurrence, and a plant-based eating pattern has been hypothesized to be protective. Whether a plant-based diet without specific energy goals will result in weight loss or changes in body composition in women who have been...

    journal_title：European journal of nutrition

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00394-004-0487-x

    authors： Thomson CA,Rock CL,Giuliano AR,Newton TR,Cui H,Reid PM,Green TL,Alberts DS,Women's Healthy Eating & Living Study Group.

    更新日期：2005-02-01 00:00:00

  • Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor.

    abstract：:Carotenoids are important micronutrients in the human diet and are present in human serum at micromolar concentrations. In addition to their antioxidant potential, carotenoids obtain physiologically relevant properties such as influencing cellular signal pathways, gene expression or induction of detoxifying enzymes. I...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-004-0475-1

    authors： Rühl R,Sczech R,Landes N,Pfluger P,Kluth D,Schweigert FJ

    更新日期：2004-12-01 00:00:00

  • Influence of 4-week multi-strain probiotic administration on resting-state functional connectivity in healthy volunteers.

    abstract：PURPOSE:Experimental investigations in rodents have contributed significantly to our current understanding of the potential importance of the gut microbiome and brain interactions for neurotransmitter expression, neurodevelopment, and behaviour. However, clinical evidence to support such interactions is still scarce. T...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-018-1732-z

    authors： Bagga D,Aigner CS,Reichert JL,Cecchetto C,Fischmeister FPS,Holzer P,Moissl-Eichinger C,Schöpf V

    更新日期：2019-08-01 00:00:00