Abstract：
PURPOSE:The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO). METHODS:Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period. RESULTS:CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC0-12) in comparison with the unformulated StdC. CONCLUSION:The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Purpura M,Lowery RP,Wilson JM,Mannan H,Münch G,Razmovski-Naumovski Vdoi
10.1007/s00394-016-1376-9subject
Has Abstractpub_date
2018-04-01 00:00:00pages
929-938issue
3eissn
1436-6207issn
1436-6215pii
10.1007/s00394-016-1376-9journal_volume
57pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. AIM OF THE STUDY:To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel t...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-003-0421-7
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abstract：PURPOSE:This survey aimed to assess iodine status in a female population at different ages, also investigating their eating habits. METHODS:We measured urinary iodine concentrations (UIC) in: 634 females at puberty and 361 fertile women in 246 of whom were considered also their children (134 daughters and 120 sons). A...
journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 杂志文章
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abstract：: ...
journal_title：European journal of nutrition
pub_type： 信件
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更新日期：2018-09-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2015-12-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 杂志文章
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2005-08-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02126-x
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2007-04-01 00:00:00
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pub_type： 已发布勘误
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pub_type： 杂志文章,meta分析
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journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Lutein is a carotenoid that may play a role in eye health. Human milk typically contains higher concentrations of lutein than infant formula. Preliminary data suggest there are differences in serum lutein concentrations between breastfed and formula-fed infants. AIM OF THE STUDY:To measure the serum lutein ...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Carotenoids in serum vary between countries and within populations with evidence suggesting a qualitative relationship to diet. Breast milk carotenoids furnish a source of vitamin A and potentially provide immunoprotection and other health benefits for infants. There have been numerous studies of milk carote...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-003-0403-9
更新日期：2003-06-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章
doi：10.1007/s00394-012-0377-6
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Mediterranean diet (MED) is associated with health benefits, yet scarce data exist regarding the role of MED in inflammatory bowel diseases (IBD). Herein, we aimed to evaluate the association between MED and inflammatory markers in patients with IBD after pouch surgery. METHODS:Consecutive patients after po...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02158-3
更新日期：2020-10-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-01999-2
更新日期：2019-10-01 00:00:00
