Abstract：
PURPOSE:Heme iron may contribute to the development of atherosclerosis by catalyzing production of hydroxyl-free radicals and promoting low-density lipoprotein oxidation. However, epidemiologic findings regarding the association between heme iron intake and risk of coronary heart disease (CHD) are inconsistent. We aimed to investigate the association by carrying out a meta-analysis of prospective studies. METHODS:Relevant studies were identified by using PubMed and EMBASE databases between January 1966 and April 2013 and also by manually reviewing the reference lists of retrieved publications. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were computed using a random-effects model. RESULTS:Six prospective studies, which contained a total of 131,553 participants and 2,459 CHD cases, met the inclusion criteria. Combined results indicated that participants with higher heme iron intake had a 31% increased risk of CHD, compared with those with lower intake (RR = 1.31, 95% CI 1.04-1.67), with significant heterogeneity (P(heterogeneity) = 0.05, I(2) = 55.0%). Excluding the only study from Japan (limiting to Western studies) yielded a RR of 1.46 (95% CI 1.21-1.76), with no study heterogeneity (P(heterogeneity) = 0.44, I(2) = 0.0%). The dose-response RR of CHD for an increase in heme iron intake of 1 mg/day was 1.27 (95% CI 1.10-1.47), with low heterogeneity (P (heterogeneity) = 0.25, I (2) = 25.8%). We observed no significant publication bias. CONCLUSIONS:This meta-analysis suggests that heme iron intake was associated with an increased risk of CHD.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Yang W,Li B,Dong X,Zhang XQ,Zeng Y,Zhou JL,Tang YH,Xu JJdoi
10.1007/s00394-013-0535-5subject
Has Abstractpub_date
2014-01-01 00:00:00pages
395-400issue
2eissn
1436-6207issn
1436-6215journal_volume
53pub_type
杂志文章,meta分析abstract：OBJECTIVE:To examine the determinants of adiponectin levels (i) in 23 women with anorexia nervosa (mean BMI 15.0 +/- 1.2) and 43 healthy normal weight females (mean BMI 22.3 +/- 2.3; cross-sectional design) as well as (ii) after six and twelve weeks of weight gain in subgroups of 18 and 11 anorectic patients (mean weig...
journal_title：European journal of nutrition
pub_type： 杂志文章
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abstract：BACKGROUND:DNA methylation is an important epigenetic process for transcriptional control of human genome including those genes involved in cancer initiation and progression. Clinical studies have suggested that biological explanation to the protective effect of some nutrients could be linked with the DNA methylation. ...
journal_title：European journal of nutrition
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abstract：PURPOSE:Risks of dehydration and cognitive decline increase with advancing age, yet the relation between dehydration, water intake, and cognitive performance among older adults remains understudied. METHODS:Using data from the 2011-2014 cycles of the Nutrition and Health Examination Survey (NHANES), we tested if calcu...
journal_title：European journal of nutrition
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：PURPOSE:The aim of the current study was to determine the incorporation of cis (c) 9, trans (t) 11-conjugated linoleic acid (CLA) and t10, c12-CLA into porcine erythrocytes-both isomers were supplemented in equal proportions. METHODS:The study group consisted of 16 piglets randomly assigned into experimental and contr...
journal_title：European journal of nutrition
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journal_title：European journal of nutrition
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更新日期：2007-02-01 00:00:00
abstract：PURPOSE:Epidemiologic data linking adherence to the dietary approaches to stop hypertension (DASH) diet and metabolic abnormalities is sparse and inconsistent. The association between habitual intake of the DASH diet and metabolic syndrome (MetS) has not been investigated in the Middle East. We aimed to determine wheth...
journal_title：European journal of nutrition
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abstract：PURPOSE:Few studies have evaluated the association of fruit and vegetable (FV) intake and pre-diabetes. However, these studies are very limited and incomplete. Therefore, the aim of our study was to compare FV consumption and their subgroups between pre-diabetic and control subjects. METHODS:This case-control study in...
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journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title：European journal of nutrition
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更新日期：2009-02-01 00:00:00
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journal_title：European journal of nutrition
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pub_type： 杂志文章,多中心研究
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journal_title：European journal of nutrition
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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journal_title：European journal of nutrition
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更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Reactive oxygen radicals have been implicated in the pathophysiology of many neurologic disorders and brain dysfunctions. Kainic acid has been used as a model agent for the study of neurotoxicity of various excitatory amino acids, since it induces neuronal damage through excessive production of reactive oxyg...
journal_title：European journal of nutrition
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更新日期：2006-03-01 00:00:00
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journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
abstract：:Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, ...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Conjugated linoleic acid (CLA) has received great attention in recent years because of its pleiotropic biological activities, but considerably fewer studies have been published addressing its role in serum lipids and atherosclerosis compared to other topics covered. AIMS OF THE STUDY:The aim of the present ...
journal_title：European journal of nutrition
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:To investigate whether a low meat content of complementary food as accepted by EU law increases the risk of well-nourished infants to develop iron deficiency during the complementary feeding period. METHODS:Term born, healthy infants were randomized into a 'High Meat' Group (HM, n = 48) receiving commercial...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0043-9
更新日期：2010-02-01 00:00:00
