Abstract：
PURPOSE:Telomere length is a biomarker for aging. It is known that oxidative stress can accelerate telomere shortening, whereas antioxidants can delay their shortening. Carotenoids as antioxidants are favorably associated with health- and aging-related diseases caused by oxidative stress, but their association with telomere length is less certain. We investigated the association between blood carotenoid levels and leukocyte telomere length in a representative sample of US adults. METHODS:We analyzed 3660 participants aged 20 years and older in the 1999-2002 National Health and Nutrition Examination Survey. The levels of carotenoids-alpha-carotene, beta-carotene (trans + cis), beta-cryptoxanthin, combined lutein/zeaxanthin, and trans-lycopene-were measured using high-performance liquid chromatography. The leukocyte telomere length (T/S ratio) was assayed using the quantitative polymerase chain reaction method. RESULTS:A doubling of blood alpha-carotene, beta-carotene (trans + cis), and beta-cryptoxanthin was associated with approximately 2 % longer telomeres. Compared with the lowest carotenoid quartile of alpha-carotene, beta-carotene (trans + cis), and beta-cryptoxanthin, telomere length for adults with the highest quartiles was significantly increased by 5-8 %. CONCLUSION:We found that increasing levels of blood carotenoid were significantly associated with longer leukocyte telomeres in US adults. High intake of carotenoid-rich food may play a role in protecting telomeres and regulating telomere length.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Min KB,Min JYdoi
10.1007/s00394-016-1152-xsubject
Has Abstractpub_date
2017-04-01 00:00:00pages
1045-1052issue
3eissn
1436-6207issn
1436-6215pii
10.1007/s00394-016-1152-xjournal_volume
56pub_type
杂志文章abstract：PURPOSES:Hepatic lipid overloading induces lipotoxicity which can cause hepatocyte damage, fibrosis, and eventually progress to cirrhosis, which is associated with nonalcoholic fatty liver disease. Adiponectin receptors play important roles in regulating lipid metabolism. In this study, we used a lentivirus system to o...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0594-7
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND AND AIM:Breast cancer remains a leading cause of mortality among women. In metastasis, cascade migration of cancer cells and invasion of extracellular matrix (ECM) represent critical steps. Urokinase-type plasminogen activator (uPA), as well as metalloproteinases MMP-2 and MMP-9, strongly contribute to ECM r...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0542-6
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Vegetarian and vegan diets have gained popularity in Switzerland. The nutritional status of individuals who have adopted such diets, however, has not been investigated. The aim of this study was to assess the intake and status of selected vitamins and minerals among vegetarian and vegan adults living in Switzer...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1079-7
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:To determine the influence of meal composition on the glycaemic impact of different carbohydrate staples, and the accuracy of "adjusted calculated meal GI" compared with "measured mixed-meal GI". METHODS:In a non-blind randomized crossover trial fasted healthy subjects consumed four dinner-type mixed meals of ...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-018-1813-z
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1793-z
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Fruits and nuts may prevent or reverse common human health conditions such as obesity, diabetes and hypertension; together, these conditions are referred to as metabolic syndrome, an increasing problem. This study has investigated the responses to ellagic acid, present in many fruits and nuts, in a diet-indu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-012-0358-9
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Globally, around 20 million children suffer from severe acute malnutrition (SAM). Identifying a more economical treatment for those affected has the potential to make treatment more available and improve prognosis for recovery and future health. DESIGN/METHODS:The double-blind randomized study...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-019-01975-w
更新日期：2020-04-01 00:00:00
abstract：AIM OF THIS STUDY:was to assess the validity of a 3-day estimated dietary record, especially developed for the longitudinal study on nutrition and health status in an aging population (aged > or = 60 years) in Giessen, Germany. METHODS:The dietary record comprises 146 food items. Portion sizes of the foods consumed we...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s003940050066
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:This study aimed to assess the dietary patterns of adolescents using a food-based diet quality index and their compliance with a healthy dietary guideline METHODS: Participants included 71,553 Brazilian adolescents (12-17 years old) from the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectiona...
journal_title：European journal of nutrition
pub_type： 杂志文章,多中心研究
doi：10.1007/s00394-019-01923-8
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:Intake of specific nutrients has been linked to mental states and various indices of cognitive performance although the effects are often subtle and difficult to interpret. Measurement of so-called objective variables (e.g. reaction times) is often considered to be the gold standard for assessing outcomes in th...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-015-1143-3
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:Risks of dehydration and cognitive decline increase with advancing age, yet the relation between dehydration, water intake, and cognitive performance among older adults remains understudied. METHODS:Using data from the 2011-2014 cycles of the Nutrition and Health Examination Survey (NHANES), we tested if calcu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02152-9
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher conce...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0698-8
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:This project sought to test the role of diet-related inflammation in modulating the risk of oesophageal cancer. METHODS:A nationwide population-based case-control study was conducted from 1 December 1994 through 31 December 1997 in Sweden. All newly diagnosed patients with adenocarcinoma of the oesophagus or g...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0987-x
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:Impaired B vitamin status has been identified as a risk factor for major chronic diseases. This study aims at examining the determinants of plasma folate and vitamin B12 concentrations, considering lifestyle factors and MTHFR polymorphisms. METHODS:A total of 988 women aged 40-65 years from the French E3N coho...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-016-1365-z
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:Previously, anthocyanin-rich blueberry treatments have shown positive effects on cognition in both animals and human adults. However, little research has considered whether these benefits transfer to children. Here we describe an acute time-course and dose-response investigation considering whether these cognit...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-015-1029-4
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Choline, docosahexaenoic acid (DHA), and arachidonic acid (ARA) are essential to fetal development, particularly of the brain. These components are actively enriched in the fetus. Deprivation from placental supply may therefore result in impaired accretion in preterm infants. OBJECTIVE:To determine choline,...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-016-1220-2
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense, and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bac...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s00394-012-0415-4
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:Anemia and vitamin D deficiency are both frequent in adult patients. Whether low vitamin D metabolite levels are an independent risk factor for different subtypes of anemia remains to be studied in detail. METHODS:In 3299 patients referred for coronary angiography, we investigated the association of 25-hydroxy...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-1149-x
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disorder. Probiotics and synbiotics have been shown to improve symptoms of IBS, although mechanisms of action are currently not understood. METHODS:We investigated the effects of a 4-week oral synbiotic treatment (OMN...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1826-7
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:This survey aimed to assess iodine status in a female population at different ages, also investigating their eating habits. METHODS:We measured urinary iodine concentrations (UIC) in: 634 females at puberty and 361 fertile women in 246 of whom were considered also their children (134 daughters and 120 sons). A...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-015-0853-x
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:The aim was to compare the anthropometric and metabolic profiles and lifestyle behaviours of yogurt consumers and non-consumers and to determine if the observed differences persisted after adjustment for diet quality and related variables. METHODS:Using cross-sectional and follow-up data from the Québec Family...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1444-9
更新日期：2018-06-01 00:00:00
abstract：:In domestic animals, acid-base balance may be influenced by nutrition. The major research effort in this area has been made on the prevention of hypocalcemic postparturient paresis in dairy cows. This disorder is caused by the sudden increase of calcium secretion into the colostrum. The manipulation of the dietary cat...
journal_title：European journal of nutrition
pub_type： 杂志文章,评审
doi：10.1007/s394-001-8352-2
更新日期：2001-10-01 00:00:00
abstract：PURPOSE:Polydextrose is a low-calorie highly branched-chain glucose polymer that is poorly digested in the upper gastrointestinal tract and therefore demonstrates fibre-like properties. Fibre has been shown to increase satiety and possibly reduce food intake. Therefore, the objective of the current study was to examine...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-012-0395-4
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:Constitutive activation of the Wnt signaling pathway and its downstream effectors plays a key role in neoplastic transformation. The objective of this study was to investigate the effect of ellagic acid, a plant-derived polyphenol on Wnt/β-catenin signaling and its downstream circuits- NF-κB and mitochondrial a...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0288-y
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Both hempseed oil (HO) and flaxseed oil (FO) contain high amounts of essential fatty acids (FAs); i.e. linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (ALA, 18:3n-3), but almost in opposite ratios. An excessive intake of one essential FA over the other may interfere with the metabolism of the other whil...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-006-0621-z
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:There are limited data on the contribution of fortified foods and nutritional supplements to intakes of vitamin D in young children. Our objective was to examine the intake, adequacy, risk of excessive intake and sources of dietary vitamin D. METHODS:The nationally representative cross-sectional dietary survey...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-016-1171-7
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:It was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine. METHODS:Male Wistar rats were randomly assigned to four groups o...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-014-0775-z
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Nut consumption is associated with a protective effect against coronary heart disease, partly due to its high antioxidant content. It is hypothesized that the inclusion of nuts in the diet will improve the antioxidant status of subjects with metabolic syndrome who may be vulnerable to impaired antioxidant st...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-007-0647-x
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Vitamin A deficiency induces activation of NF-kB and impairs activities of antioxidant enzymes in aorta. AIM OF THE STUDY:We study the effect of vitamin A deficiency on the aorta histoarchitecture and the possibly contribution of its prooxidant and inflammatory effects to artery alterations. METHODS:Twenty...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0198-z
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:Advanced glycation endproducts (AGEs) are produced endogenously and also enter the body during the consumption of AGEs present in heat-processed food. It is unknown whether AGEs of dietary origin accumulate within the body of healthy individuals. AGEs can deposit within skin tissue long-term by crosslinking ext...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1495-y
更新日期：2018-09-01 00:00:00
