当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NUTRITION期刊下所有文献 > The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study).

The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study).

Abstract：

PURPOSE:We examined whether high doses of folic acid and iron supplementation in early-to-mid pregnancy affect the risk of preterm birth, low birth weight, and small for gestational age neonates, in the mother-child cohort in Crete, Greece (Rhea study). METHODS:We included 1,279 women with singleton pregnancies with complete data on supplements use in early-to-mid pregnancy and birth outcomes. Anthropometric measurements at birth were obtained from medical records. Red blood cell folate concentrations in cord blood were measured in a subsample of the study population (n = 58). RESULTS:Sixty-six percent of the study participants reported high doses of supplemental folic acid use (5 mg/day), while 21 % reported excessive doses of folic acid use (>5 mg/day) in early-to-mid pregnancy. Daily intake of 5-mg supplemental folic acid was associated with a 31 % decrease in the risk of preterm birth (RR, 0.69; 95 % CI, 0.44, 0.99), 60 % decrease in the risk of delivering a low birth weight neonate (RR, 0.40; 95 % CI, 0.21, 0.76), and 66 % decrease in the risk of delivering a small for gestational age (SGA) neonate (RR, 0.34; 95 % CI, 0.16, 0.73). Daily doses of iron supplementation more than 100 mg were associated with a twofold increased risk for SGA neonates (RR, 2.14; 95 % CI, 0.99, 5.97). CONCLUSION:These findings suggest that high daily doses of supplementary folic acid in early-to-mid pregnancy may be protective for preterm birth, low birth weight, and small for gestational age neonates, while high daily doses of supplementary iron may be harmful for fetal growth.

journal_name

Eur J Nutr

journal_title

European journal of nutrition

authors

Papadopoulou E,Stratakis N,Roumeliotaki T,Sarri K,Merlo DF,Kogevinas M,Chatzi L

doi

10.1007/s00394-012-0339-z

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

327-36

issue

1

eissn

1436-6207

issn

1436-6215

journal_volume

52

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF NUTRITION文献大全
  • Effects on parameters of glucose homeostasis in healthy humans from ingestion of leguminous versus maize starches.

    abstract：BACKGROUND:Due to their lower glycaemic index, leguminous seeds affect human carbohydrate metabolism lesser than do cereals. Problems, however, could arise from side effects, e.g., increasing flatulence. AIM OF THE STUDY AND METHODS:In 26 healthy subjects, metabolic and symptomatic responses following acute ingestion ...

    journal_title：European journal of nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s003940050060

    authors： Seewi G,Gnauck G,Stute R,Chantelau E

    更新日期：1999-08-01 00:00:00

  • Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects.

    abstract：BACKGOUND:Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE:To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postpr...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-018-1612-6

    authors： Smolders L,Mensink RP,van den Driessche JJ,Joris PJ,Plat J

    更新日期：2019-04-01 00:00:00

  • A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial.

    abstract：PURPOSE:To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. METHODS:In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. S...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-015-0859-4

    authors： Yao P,Lu L,Hu Y,Liu G,Chen X,Sun L,Ye X,Zheng H,Chen Y,Hu FB,Li H,Lin X

    更新日期：2016-02-01 00:00:00

  • Polydextrose: its impact on short-term food intake and subjective feelings of satiety in males-a randomized controlled cross-over study.

    abstract：PURPOSE:Polydextrose is a low-calorie highly branched-chain glucose polymer that is poorly digested in the upper gastrointestinal tract and therefore demonstrates fibre-like properties. Fibre has been shown to increase satiety and possibly reduce food intake. Therefore, the objective of the current study was to examine...

    journal_title：European journal of nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00394-012-0395-4

    authors： Ranawana V,Muller A,Henry CJ

    更新日期：2013-04-01 00:00:00

  • The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects.

    abstract：PURPOSE:Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mec...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-016-1275-0

    authors： Thomas NS,George K,Arivalagan S,Mani V,Siddique AI,Namasivayam N

    更新日期：2017-10-01 00:00:00

  • Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells.

    abstract：PURPOSE:Pomegranate fruit, Punica granatum L. (Punicaceae), and its constituents have been shown to inhibit inflammation. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. METHODS:An enzyme immunoassay (EIA) was used to measure prostag...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0984-0

    authors： Velagapudi R,Baco G,Khela S,Okorji U,Olajide O

    更新日期：2016-06-01 00:00:00

  • Correction to: Large artery stiffness is associated with salt intake in young healthy black but not white adults: the African-PREDICT study.

    abstract：:In the Original publication of the article Fig. 1 was published incorrectly. The correct figure is given below. The original article has been corrected. ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s00394-018-1800-4

    authors： Strauss M,Smith W,Kruger R,van der Westhuizen B,Schutte AE

    更新日期：2018-10-01 00:00:00

  • Identification of change-points in the relationship between food groups in the Mediterranean diet and overall mortality: an 'a posteriori' approach.

    abstract：BACKGROUND:Adherence to Mediterranean diet has been shown to be associated with a better health and greater survival. The aim of the present study was to identify change-points in the relationship between food groups composing Mediterranean diet and overall mortality. METHODS:The population of the Greek EPIC prospecti...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-011-0202-7

    authors： Sofi F,Abbate R,Gensini GF,Casini A,Trichopoulou A,Bamia C

    更新日期：2012-03-01 00:00:00

  • Disparate metabolic effects of blackcurrant seed oil in rats fed a basal and obesogenic diet.

    abstract：PURPOSE:It was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine. METHODS:Male Wistar rats were randomly assigned to four groups o...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-014-0775-z

    authors： Jurgoński A,Fotschki B,Juśkiewicz J

    更新日期：2015-09-01 00:00:00

  • Low FODMAP diet significantly improves IBS symptoms: an Irish retrospective cohort study.

    abstract：INTRODUCTION:There is growing evidence that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) improves symptoms in irritable bowel syndrome (IBS) patients. We aimed to retrospectively investigate the effects of this diet in Irish IBS cohort over a 12-month follow-up period...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02074-6

    authors： Nawawi KNM,Belov M,Goulding C

    更新日期：2020-08-01 00:00:00

  • Cholecystokinin secretion induced by beta-conglycinin peptone depends on Galphaq-mediated pathways in enteroendocrine cells.

    abstract：BACKGROUND:Intraduodenal administration of peptone prepared from soybean beta-conglycinin (BconP) stimulates cholecystokinin (CCK) secretion from enteroendocrine cells, and suppresses food intake in rats. However, the sensing mechanism of BconP by CCK-producing cells is unknown. AIM OF THE STUDY:We investigated signal...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-008-0764-1

    authors： Hira T,Maekawa T,Asano K,Hara H

    更新日期：2009-03-01 00:00:00

  • Mediterranean diet and mortality in Switzerland: an alpine paradox?

    abstract：PURPOSE:Reports on the protective effect of a Mediterranean diet on mortality usually refer to populations from Mediterranean countries, leaving uncertain whether really diet is the fundamental cause. Our aim was to examine the effect of a Mediterranean diet on mortality in Switzerland, a country combining cultural inf...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-014-0695-y

    authors： Vormund K,Braun J,Rohrmann S,Bopp M,Ballmer P,Faeh D

    更新日期：2015-02-01 00:00:00

  • Adherence to the Mediterranean diet is associated with decreased fecal calprotectin in patients with ulcerative colitis after pouch surgery.

    abstract：BACKGROUND:Mediterranean diet (MED) is associated with health benefits, yet scarce data exist regarding the role of MED in inflammatory bowel diseases (IBD). Herein, we aimed to evaluate the association between MED and inflammatory markers in patients with IBD after pouch surgery. METHODS:Consecutive patients after po...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02158-3

    authors： Godny L,Reshef L,Pfeffer-Gik T,Goren I,Yanai H,Tulchinsky H,Gophna U,Dotan I

    更新日期：2020-10-01 00:00:00

  • Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study.

    abstract：BACKGROUND:The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02087-1

    authors： Cano-Ibáñez N,Bueno-Cavanillas A,Martínez-González MÁ,Salas-Salvadó J,Corella D,Freixer GL,Romaguera D,Vioque J,Alonso-Gómez ÁM,Wärnberg J,Martínez JA,Serra-Majem L,Estruch R,Tinahones FJ,Lapetra J,Pintó X,Tur JA,García

    更新日期：2020-09-01 00:00:00

  • Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial microbiota: a randomised controlled trial.

    abstract：PURPOSE:Wheat bran fibre has a beneficial effect on gastrointestinal function, but evidence for wheat germ is scarce. Accordingly, we evaluated the effects of daily intake of wheat germ on gastrointestinal discomfort and gut microbiota by adding wheat germ to refined (white) wheat bread, the most consumed bread type. W...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02045-x

    authors： Moreira-Rosário A,Marques C,Pinheiro H,Norberto S,Sintra D,Teixeira JA,Calhau C,Azevedo LF

    更新日期：2020-08-01 00:00:00

  • Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota.

    abstract：BACKGROUND:Diet has an important role in host-microbiome interplay, which may result in intestinal permeability changes and physiopathological effects at a systemic level. Despite the importance of maternal microbiota as the main contributor to the initial microbial seeding, little is known about the effects of materna...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-020-02337-7

    authors： Selma-Royo M,García-Mantrana I,Calatayud M,Parra-Llorca A,Martínez-Costa C,Collado MC

    更新日期：2020-07-29 00:00:00

  • Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study.

    abstract：:The original version of this article unfortunately contained a mistake. José M. Gámez was not listed among the authors. ...

    journal_title：European journal of nutrition

    pub_type： 已发布勘误

    doi：10.1007/s00394-020-02433-8

    authors： Navarrete-Muñoz EM,Vioque J,Toledo E,Oncina-Canovas A,Martínez-González MÁ,Salas-Salvadó J,Corella D,Fitó M,Romaguera D,Alonso-Gómez ÁM,Wärnberg J,Martínez JA,Serra-Majem L,Estruch R,Tinahones FJ,Lapetra J,Pintó X,Tur J

    更新日期：2020-12-05 00:00:00

  • Beneficial effects of mung bean seed coat on the prevention of high-fat diet-induced obesity and the modulation of gut microbiota in mice.

    abstract：PURPOSE:Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-020-02395-x

    authors： Hou D,Zhao Q,Yousaf L,Xue Y,Shen Q

    更新日期：2020-10-01 00:00:00

  • A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men.

    abstract：PURPOSE:Laboratory studies have suggested that vitamin D inadequacy may be implicated in development of hypertension. Evidence from epidemiologic studies remains limited. We aim to examine the prospective associations of circulating vitamin D metabolites, vitamin D receptor (VDR) gene polymorphisms, and their interacti...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-012-0480-8

    authors： Wang L,Ma J,Manson JE,Buring JE,Gaziano JM,Sesso HD

    更新日期：2013-10-01 00:00:00

  • Leptin gene polymorphism (rs7799039; G2548A) is associated with changes in serum lipid concentrations during pregnancy: a prospective cohort study.

    abstract：PURPOSE:Little is known about the effects of leptin and leptin receptor polymorphisms on lipid changes during pregnancy. The aims of this study were to evaluate the associations between the single nucleotide polymorphisms (SNPs) of leptin and leptin receptor genes and the lipid concentrations during pregnancy; and to t...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-019-02049-7

    authors： Farias DR,Alves-Santos NH,Eshriqui I,Martins MC,Struchiner CJ,Lepsch J,Costa N,Kac G

    更新日期：2020-08-01 00:00:00

  • The effect of chromium on inflammatory markers, 1st and 2nd phase insulin secretion in type 2 diabetes.

    abstract：OBJECTIVE:Impaired insulin sensitivity (SI) and β-cell function are the two main causes of type 2 diabetes (T2D) and are related to low-grade inflammation status. Trivalent chromium has shown to improve SI in our previous study. This might be due to the ability of decreasing interleukin-6 (IL-6) and tumor necrosis fact...

    journal_title：European journal of nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00394-013-0508-8

    authors： Chen YL,Lin JD,Hsia TL,Mao FC,Hsu CH,Pei D

    更新日期：2014-02-01 00:00:00

  • Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers.

    abstract：BACKGROUND:DNA methylation is an important epigenetic process for transcriptional control of human genome including those genes involved in cancer initiation and progression. Clinical studies have suggested that biological explanation to the protective effect of some nutrients could be linked with the DNA methylation. ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-009-0010-5

    authors： Galván-Portillo MV,Cantoral A,Oñate-Ocaña LF,Chen J,Herrera-Goepfert R,Torres-Sanchez L,Hernandez-Ramirez RU,Palma-Coca O,López-Carrillo L

    更新日期：2009-08-01 00:00:00

  • Adaptation of Sprague Dawley rats to long-term feeding of high fat or high fructose diets.

    abstract：BACKGROUND:Present animal models used to emulate type 2 diabetes may not accurately reflect the metabolic changes that occur in humans. AIM OF THE STUDY:The purpose of this research was to evaluate diets reported to induce insulin resistance and impaired glucose metabolism in rats as a potentially useful model for stu...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s003940070016

    authors： Stark AH,Timar B,Madar Z

    更新日期：2000-10-01 00:00:00

  • Probiotic Lactobacillus casei Zhang reduces pro-inflammatory cytokine production and hepatic inflammation in a rat model of acute liver failure.

    abstract：PURPOSE:In this study, we sought to find the effects and mechanisms of probiotic Lactobacillus casei Zhang (L. casei Zhang) on the pro-inflammatory cytokine production and hepatic inflammatory response in a rat model of acute liver failure induced by lipopolysaccharide (LPS) and d-galactosamine (GalN). METHODS:Male Wi...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0904-3

    authors： Wang Y,Xie J,Li Y,Dong S,Liu H,Chen J,Wang Y,Zhao S,Zhang Y,Zhang H

    更新日期：2016-03-01 00:00:00

  • Vitamin E reduces lipid peroxidation in experimental hepatotoxicity in rats.

    abstract：BACKGROUND AND AIMS:Lipid peroxidation is believed to be involved in the pathophysiology of a number of diseases and in the process of aging. This study investigates the effects of dietary supplementation with vitamin E (20 g/kg diet of all-rac-alpha-tocopheryl succinate for 3 weeks) on both non-enzymatic and enzymatic...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/pl00007381

    authors： Södergren E,Cederberg J,Vessby B,Basu S

    更新日期：2001-02-01 00:00:00

  • Low-level mercury, omega-3 index and neurobehavioral outcomes in an adult US coastal population.

    abstract：BACKGROUND:Neurodevelopmental effects of omega-3 fatty acids and mercury from fish consumption have been characterized in children. In contrast, neurobehavioral outcomes associated with fish are not well studied in adults. OBJECTIVE:This study of avid seafood consumers on Long Island (NY, USA) sought to define associa...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-015-0890-5

    authors： Vacchi-Suzzi C,Karimi R,Kruse D,Silbernagel SM,Levine KE,Rohlman DS,Meliker JR

    更新日期：2016-03-01 00:00:00

  • Consumption of soy-based infant formula is not associated with early onset of puberty.

    abstract：PURPOSE:The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula. METHODS:A nested case-control study was ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-018-1668-3

    authors： Sinai T,Ben-Avraham S,Guelmann-Mizrahi I,Goldberg MR,Naugolni L,Askapa G,Katz Y,Rachmiel M

    更新日期：2019-03-01 00:00:00

  • Determinants of plasma adiponectin levels in patients with anorexia nervosa examined before and after weight gain.

    abstract：OBJECTIVE:To examine the determinants of adiponectin levels (i) in 23 women with anorexia nervosa (mean BMI 15.0 +/- 1.2) and 43 healthy normal weight females (mean BMI 22.3 +/- 2.3; cross-sectional design) as well as (ii) after six and twelve weeks of weight gain in subgroups of 18 and 11 anorectic patients (mean weig...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-005-0533-3

    authors： Bosy-Westphal A,Brabant G,Haas V,Onur S,Paul T,Nutzinger D,Klein H,Hauer M,Müller MJ

    更新日期：2005-09-01 00:00:00

  • Recommended number of participants in iodine nutrition studies is similar before and after an iodine fortification programme.

    abstract：BACKGROUND:Iodine fortification programs have been applied in many iodine deficient regions. Iodine excess is also unfavourable, and it is recommended to monitor iodine status by measuring urinary iodine concentration (UIC). The number of samples needed in such monitoring depends on the variation in UIC. However, it is...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-013-0551-5

    authors： Karmisholt J,Laurberg P,Andersen S

    更新日期：2014-01-01 00:00:00

  • Association between erythrocyte fatty acids in de novo lipogenesis pathway and DXA-derived body fat and trunk fat distribution in Chinese adults: a prospective study.

    abstract：PURPOSE:Higher levels of fatty acids (FAs) in the de novo lipogenesis (DNL) pathway might be associated with higher levels of fat mass (FM), while limited evidence is available from the general population. We aimed to examine the associations between DNL-FAs and body fat and fat distribution in a general population of ...

    journal_title：European journal of nutrition

    pub_type： 杂志文章

    doi：10.1007/s00394-018-1866-z

    authors： Zeng FF,Chen ZY,Zheng JS,Lin JS,Li YH,Qiu R,Wang C,Sun LL,Chen YM

    更新日期：2019-12-01 00:00:00