Abstract:
PURPOSE:Little is known about the effects of leptin and leptin receptor polymorphisms on lipid changes during pregnancy. The aims of this study were to evaluate the associations between the single nucleotide polymorphisms (SNPs) of leptin and leptin receptor genes and the lipid concentrations during pregnancy; and to test whether dietary intake is a mediator in these associations. METHODS:A prospective cohort of 154 pregnant women was followed up in Rio de Janeiro, Brazil during the following gestational periods: 5-13th, 20-26th and 30-36th weeks. HDL-C, total cholesterol (TC) and triglyceride (TG) were measured by the enzymatic colorimetric method, and LDL-C was calculated. DNA was extracted by the phenol-chloroform method, and leptin (G2548A, rs7799039) and leptin receptor SNPs (Q223R; rs1137101 and K109R; rs1137100) were genotyped using real-time PCR. Statistical analyses included linear mixed-effect models. RESULTS:Women with the AA genotype of G2548A polymorphism reported a higher fat and total energy intake and had a higher increase in TG concentration during pregnancy than women with AG or GG genotype. The association between G2548A SNP and TG concentrations was not attenuated by adjusting for total lipid (g) and energy (kcal) intake. We did not observe significant associations between the Q223R and K109R SNPs and the lipid concentrations. CONCLUSIONS:Women homozygous for the A allele of the leptin SNP (G2548A) had a higher increase in TG concentrations per gestational week compared with women with the AG or GG genotype. This is an exploratory and hypothesis-generating study, and the results need confirmation in studies with larger sample sizes.'
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Farias DR,Alves-Santos NH,Eshriqui I,Martins MC,Struchiner CJ,Lepsch J,Costa N,Kac Gdoi
10.1007/s00394-019-02049-7subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1999-2009issue
5eissn
1436-6207issn
1436-6215pii
10.1007/s00394-019-02049-7journal_volume
59pub_type
杂志文章abstract:PURPOSE:Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders. The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can i...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02382-2
更新日期:2020-09-10 00:00:00
abstract:PURPOSE:Berries and mixed berry products exert acute effects on postprandial glycaemia and insulinemia, but very few berries have been studied, and primarily in normal weight subjects. Sea buckthorn and strawberry are compositionally widely different berries and may likely produce different responses. The effects of st...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-017-1550-8
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Conifer seeds are used for food preparation in several countries. Aim of the study To assess the lipid-lowering and antiatherogenic properties of maritime pine (Pinuspinaster) seed oil. METHODS:The effects of maritime pine oil supplementation (20% w/w) for 2 weeks were compared to those of coconut and sunfl...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s394-001-8355-6
更新日期:2001-12-01 00:00:00
abstract:PURPOSE:This study was aimed to determine the impact of hydroxytyrosol (HT), a minor compound found in olive oil, on breast cancer stem cells (BCSCs) and the migration capacity of triple-negative breast cancer (TNBC) cell lines through the alteration of epithelial-to-mesenchymal transition (EMT) and embryonic signaling...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1864-1
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-018-1687-0
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Coffee is known to contain phytochemicals with antioxidant potential. The aim of this study was to investigate possible antioxidant effects of coffee in healthy human volunteers. METHODS:A placebo-controlled intervention trial was carried out on 160 healthy human subjects, randomised into three groups, receivi...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-016-1336-4
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Grapes and wine contain high concentrations of polyphenolic compounds. Although their cancer protective effect has been well documented, their activity as anticarcinogens should be cautiously considered since the molecular bases of action and their applicability to human cancer prevention are still unclear. ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-003-0398-2
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:Hepatic fatty acid synthesis is influenced by several nutritional and hormonal factors. In this study, we have investigated the effects of distinct experimental diets enriched in carbohydrate or in fat on hepatic lipogenesis. METHODS:Male Wistar rats were divided into four groups and fed distinct experimental ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0613-8
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Chronic sugar-sweetened beverage (SSB) consumption is associated with obesity and type 2 diabetes mellitus (T2DM). Hyperglycaemia contributes to metabolic alterations observed in T2DM, such as reduced oxidative capacity and elevated glycolytic and lipogenic enzyme expressions in skeletal muscle tissue. We aimed...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章
doi:10.1007/s00394-012-0401-x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Mild iodine deficiency (MID) is endemic in Belgium. Previous surveys, which assessed iodine nutrition in Belgium, focused on children. The iodine status of adults and the influence of ethnicity or seasonality on urinary iodine concentrations (UIC) have not been investigated. Since the nutritional profile of ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-010-0137-4
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individua...
journal_title:European journal of nutrition
pub_type: 杂志文章,多中心研究
doi:10.1007/s00394-012-0473-7
更新日期:2013-10-01 00:00:00
abstract:: ...
journal_title:European journal of nutrition
pub_type: 评论,信件
doi:10.1007/s00394-018-1836-5
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:It is thought that total energy intake in women is increased during the luteal versus follicular phase of the menstrual cycle; however, less is understood regarding changes in diet composition (i.e., macro- and micronutrient intakes) across the cycle. The aim of this study was to investigate changes in macronut...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-015-0931-0
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Osteoporosis is associated with both lower health-related quality of life and depression in older people. We examined the independent and combined effects of a multi-component exercise program and calcium-vitamin D3 fortified milk on health-related quality of life (HR-QoL) and depression in older men. METHODS:...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-019-01969-8
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we...
journal_title:European journal of nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00394-016-1376-9
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Conjugated linoleic acid (CLA) has received great attention in recent years because of its pleiotropic biological activities, but considerably fewer studies have been published addressing its role in serum lipids and atherosclerosis compared to other topics covered. AIMS OF THE STUDY:The aim of the present ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-007-0653-z
更新日期:2007-06-01 00:00:00
abstract::The awareness is increasing that in the colon many metabolic processes take place in relation to the fermentation of our food, which might be relevant for health and disease. However, the relation between food, colon metabolism and health or disease is far from clear. In this overview, the physiology of colonic metabo...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-002-1101-8
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:Serum calcium and phosphorus abnormalities are associated with cardiovascular disorders in general population, but evidence among patients with established coronary heart disease (CHD) is limited and controversial. This study aimed to investigate the associations of baseline serum calcium and phosphorus levels ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1518-8
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:The only effective and safe treatment of celiac disease (CD) continues being strict exclusion of gluten for life, the so-called gluten-free diet (GFD). Although this treatment is highly successful, following strict GFD poses difficulties to patients in family, social and working contexts, deteriorating his/her ...
journal_title:European journal of nutrition
pub_type: 杂志文章,评审
doi:10.1007/s00394-016-1238-5
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND AIM:Breast cancer remains a leading cause of mortality among women. In metastasis, cascade migration of cancer cells and invasion of extracellular matrix (ECM) represent critical steps. Urokinase-type plasminogen activator (uPA), as well as metalloproteinases MMP-2 and MMP-9, strongly contribute to ECM r...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0542-6
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose i...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1456-5
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:Telomere length is a biomarker for aging. It is known that oxidative stress can accelerate telomere shortening, whereas antioxidants can delay their shortening. Carotenoids as antioxidants are favorably associated with health- and aging-related diseases caused by oxidative stress, but their association with tel...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1152-x
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:We investigated effects of ground whole flaxseed supplementation on erythrocyte polyunsaturated fatty acids (PUFAs) and serum biomarkers of inflammation, endothelial dysfunction, oxidative stress, and thrombosis in Chinese with risk factors of metabolic syndrome (MetS). METHODS:This study was a secondary analy...
journal_title:European journal of nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00394-012-0461-y
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Intraduodenal administration of peptone prepared from soybean beta-conglycinin (BconP) stimulates cholecystokinin (CCK) secretion from enteroendocrine cells, and suppresses food intake in rats. However, the sensing mechanism of BconP by CCK-producing cells is unknown. AIM OF THE STUDY:We investigated signal...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-008-0764-1
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:Iron is an essential micronutrient that participates in a number of vital reactions and its absorption may be altered by various nutritional factors such as other micronutrients. Our hypothesis is that iron absorption is decreased because of the interactions with zinc and calcium. We evaluated the interaction b...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1535-7
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Adipose tissue-associated chronic inflammation is involved in the pathogenesis of obesity-related diseases. Dietary fatty acids are known to influence inflammatory processes. The aim of this study was to investigate, whether diets with regular fat contents but variable fat qualities affect adipose tissue-associ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-013-0518-6
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:Few studies have evaluated the association of fruit and vegetable (FV) intake and pre-diabetes. However, these studies are very limited and incomplete. Therefore, the aim of our study was to compare FV consumption and their subgroups between pre-diabetic and control subjects. METHODS:This case-control study in...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-017-1569-x
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Compared to a healthy population, the gut microbiota in type 2 diabetes presents with several unfavourable features that may impair glucose regulation. The aim of this study was to evaluate the prebiotic effect of inulin-type fructans on the faecal microbiota and short-chain fatty acids (SCFA) in patients with ...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02282-5
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Diet has an important role in host-microbiome interplay, which may result in intestinal permeability changes and physiopathological effects at a systemic level. Despite the importance of maternal microbiota as the main contributor to the initial microbial seeding, little is known about the effects of materna...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-020-02337-7
更新日期:2020-07-29 00:00:00
abstract:PURPOSE:Exposure to breastfeeding improves the survival, health, and development of children; therefore, breast milk is recommended as the exclusive nutrient source for feeding term infants during the first 6 months. This cross-sectional study aimed to determine the possible association between exposure to exclusive br...
journal_title:European journal of nutrition
pub_type: 杂志文章
doi:10.1007/s00394-016-1337-3
更新日期:2018-03-01 00:00:00