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Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats.

Abstract：

PURPOSE:The consumption of refined, fructose-enriched food continuously increases and has been linked to development of obesity, especially in young population. Low-grade inflammation and increased oxidative stress have been implicated in the pathogenesis of obesity-related disorders including type 2 diabetes. In this study, we examined alterations in inflammation and antioxidative defense system in the visceral adipose tissue (VAT) of fructose-fed young female rats, and related them to changes in adiposity and insulin sensitivity. METHODS:We examined the effects of 9-week fructose-enriched diet applied immediately after weaning on nuclear factor κB (NF-κB) intracellular distribution, and on the expression of pro-inflammatory cytokines (IL-1β and TNFα) and key antioxidative enzymes in the VAT of female rats. Insulin signaling in the VAT was evaluated at the level of insulin receptor substrate-1 (IRS-1) protein and its inhibitory phosphorylation on Ser307. RESULTS:Fructose-fed rats had increased VAT mass along with increased NF-κB nuclear accumulation and elevated IL-1β, but not TNFα expression. The protein levels of antioxidative defense enzymes, mitochondrial manganese superoxide dismutase 2, and glutathione peroxidase, were reduced, while the protein content of IRS-1 and its inhibitory phosphorylation were not altered by fructose diet. CONCLUSIONS:The results suggest that fructose overconsumption-related alterations in pro-inflammatory markers and antioxidative capacity in the VAT of young female rats can be implicated in the development of adiposity, but do not affect inhibitory phosphorylation of IRS-1.

journal_name

Eur J Nutr

journal_title

European journal of nutrition

authors

Kovačević S,Nestorov J,Matić G,Elaković I

doi

10.1007/s00394-015-1065-0

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

151-160

issue

1

eissn

1436-6207

issn

1436-6215

pii

10.1007/s00394-015-1065-0

journal_volume

56

pub_type

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