Does Concurrent Use of Some Botanicals Interfere with Treatment of Tuberculosis?

abstract：:More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT...

journal_title：Neuromolecular medicine

authors： Shy ME

更新日期：2006-01-01 00:00:00

abstract：:A number of studies have investigated the association between tumor necrosis factor (TNF)-α gene polymorphisms and ischemic stroke susceptibility. However, results of different individual studies are often inconsistent. To provide a more robust evaluation of the association between polymorphisms of the TNF-α gene and ...

journal_title：Neuromolecular medicine

authors： Niu YM,Weng H,Zhang C,Yuan RX,Yan JZ,Meng XY,Luo J

更新日期：2015-12-01 00:00:00

abstract：:Origins of onset and progression of motor neurodegeneration in amyotrophic lateral sclerosis (ALS) are not clearly known, but may include impairment of mitochondrial bioenergetics. We used quantitative PCR approaches to analyze the mitochondrial oxidative phosphorylation (OXPHOS) transcriptomes of spinal cord tissue a...

journal_title：Neuromolecular medicine

authors： Ladd AC,Keeney PM,Govind MM,Bennett JP Jr

更新日期：2014-12-01 00:00:00

abstract：:P-glycoprotein (P-gp), which is coded by the MDR1 gene, in the brain capillary endothelial cell limits the entry of many drugs including antipsychotics into the brain. The aim of this study is to examine whether a functional polymorphism, a C to T substitution at position 3435 in exon 26 of the MDR1 gene, is associate...

journal_title：Neuromolecular medicine

authors： Shinkai T,De Luca V,Utsunomiya K,Sakata S,Inoue Y,Fukunaka Y,Hwang R,Ohmori O,Kennedy JL,Nakamura J

更新日期：2008-01-01 00:00:00

abstract：:Cyclin H regulates cell cycle transitions; it always forms trimeric cyclin-dependent protein kinases (CDK)-activating kinase (CAK) complex with CDK7 and MAT1 that phosphorylates a threonine residue in the CDK2 T loop region. However, neither the expression nor function of cyclin H in the central nervous system (CNS) i...

journal_title：Neuromolecular medicine

authors： Wu G,Cao J,Peng C,Yang H,Cui Z,Zhao J,Wu Q,Han J,Li H,Gu X,Zhang F

更新日期：2011-09-01 00:00:00

abstract：:Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore prot...

journal_title：Neuromolecular medicine

authors： Monshausen M,Gehring NH,Kosik KS

更新日期：2004-01-01 00:00:00

abstract：:There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner ...

journal_title：Neuromolecular medicine

authors： Kiechle T,Dedeoglu A,Kubilus J,Kowall NW,Beal MF,Friedlander RM,Hersch SM,Ferrante RJ

更新日期：2002-01-01 00:00:00

abstract：:The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence in the general population is approximately 25%. Central fat accumulation and i...

journal_title：Neuromolecular medicine

authors： Tentolouris N,Argyrakopoulou G,Katsilambros N

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Scutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in experimentally induced cerebral ischemia; however, the underlying mechanism for this has not been fully clarified. We sought to elucidate if scutellarin would exert its anti-i...

journal_title：Neuromolecular medicine

authors： Chen HL,Jia WJ,Li HE,Han H,Li F,Zhang XL,Li JJ,Yuan Y,Wu CY

更新日期：2020-06-01 00:00:00

abstract：:The frequent co-occurrence of autism spectrum disorders (ASD) and epilepsy, or paroxysmal EEG abnormalities, defines a condition termed autism-epilepsy phenotype (AEP). This condition results, in some cases , from dysfunctions of glial inwardly rectifying potassium channels (Kir), which are mainly expressed in astrocy...

journal_title：Neuromolecular medicine

authors： Marchese M,Valvo G,Moro F,Sicca F,Santorelli FM

更新日期：2016-03-01 00:00:00

abstract：:The cerebral ischemia is one of the most common diseases in the central nervous system that causes progressive disability or even death. In this connection, the inflammatory response mediated by the activated microglia is believed to play a central role in this pathogenesis. In the event of brain injury, activated mic...

journal_title：Neuromolecular medicine

authors： Yuan Y,Fang M,Wu CY,Ling EA

更新日期：2016-09-01 00:00:00

abstract：:Epileptic seizures have long been recognised as a complication of the clinical syndrome of Alzheimer's disease, particularly in advanced disease, but have hitherto been viewed essentially as epiphenomena of the neurodegenerative process. Progress with animal models of Alzheimer's disease has suggested that this view m...

journal_title：Neuromolecular medicine

authors： Larner AJ

更新日期：2010-03-01 00:00:00

abstract：:The gene encoding alpha-T-catenin, CTNNA3, is positioned within a region on chromosome 10, showing strong evidence of linkage to Alzheimer's disease (AD), and is therefore a good positional candidate gene for this disorder. We have demonstrated that alpha-T-catenin is expressed in human brain, and like other alpha-cat...

journal_title：Neuromolecular medicine

authors： Busby V,Goossens S,Nowotny P,Hamilton G,Smemo S,Harold D,Turic D,Jehu L,Myers A,Womick M,Woo D,Compton D,Doil LM,Tacey KM,Lau KF,Al-Saraj S,Killick R,Pickering-Brown S,Moore P,Hollingworth P,Archer N,Foy C,Wal

更新日期：2004-01-01 00:00:00

abstract：:Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder characterized by progressive cerebellar ataxia and epilepsy. The disease is caused by a pentanucleotide ATTCT expansion in intron 9 of the ATXN10 gene on chromosome 22q13.3. SCA10 has shown a geographical distribution throughout...

journal_title：Neuromolecular medicine

authors： Bampi GB,Bisso-Machado R,Hünemeier T,Gheno TC,Furtado GV,Veliz-Otani D,Cornejo-Olivas M,Mazzeti P,Bortolini MC,Jardim LB,Saraiva-Pereira ML,Rede Neurogenetica.

更新日期：2017-12-01 00:00:00

abstract：:Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy, regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and regulating cell death. Increasing evidence suggests that mitochondria play a central role in aging and in neurodegenerative diseases...

journal_title：Neuromolecular medicine

authors： Reddy PH

更新日期：2008-01-01 00:00:00

abstract：:Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include stimulations coupled with rowing, cycling, assisted walking and other derivatives. In this review, we studied thirteen clinical rep...

journal_title：Neuromolecular medicine

authors： Luo S,Xu H,Zuo Y,Liu X,All AH

更新日期：2020-12-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative motor disorder, marked by chronic progressive loss of neurons in the substantia nigra, thereby damaging purposeful control of movement. For decades, it was believed that PD was caused solely by environmental causes. However, the discovery of genetic factors...

journal_title：Neuromolecular medicine

authors： Cole NB,Murphy DD

更新日期：2002-01-01 00:00:00

abstract：:In addition to myelin loss and oligodendrocyte injury, axonal damage is a major cause of irreversible neurological disability in multiple sclerosis (MS). A series of studies have demonstrated that Rho kinase (ROCK) is involved in synaptic plasticity of neurons. Here, we found that ROCK activity in MS serum was elevate...

journal_title：Neuromolecular medicine

authors： Chen C,Yu JZ,Zhang Q,Zhao YF,Liu CY,Li YH,Yang WF,Ma CG,Xiao BG

更新日期：2015-12-01 00:00:00

abstract：:Accumulating studies have suggested the important role of microRNA (miRNA) in ischemic cerebral infarction. However, little is known of the modifying effect of miR-5787, a newly found miRNA, in ischemic cerebral infarction. We aim to elucidate the effect and underlying molecular mechanism of miR-5787 in the pathogenes...

journal_title：Neuromolecular medicine

authors： Bao Z,Zhang S,Li X

更新日期：2020-11-09 00:00:00

abstract：:Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individuals of Ashkenazi Jewish descent. The pathological and clinical manifestations of ...

journal_title：Neuromolecular medicine

authors： Rubin BY,Anderson SL

更新日期：2008-01-01 00:00:00

abstract：:Neurons and especially their synapses often project long thin processes that can invaginate neighboring neuronal or glial cells. These "invaginating projections" can occur in almost any combination of postsynaptic, presynaptic, and glial processes. Invaginating projections provide a precise mechanism for one neuron to...

journal_title：Neuromolecular medicine

authors： Petralia RS,Wang YX,Mattson MP,Yao PJ

更新日期：2015-09-01 00:00:00

abstract：:Adiponectin, an adipocytokine released by the adipose tissue and has important roles in the metabolic regulation and inflammatory control, may play an important roles in the physiopathology of psychiatric and neurodegenerative disorders. The aim of the present work was to evaluate adiponectin serum levels in patients ...

journal_title：Neuromolecular medicine

authors： Teixeira AL,Diniz BS,Campos AC,Miranda AS,Rocha NP,Talib LL,Gattaz WF,Forlenza OV

更新日期：2013-03-01 00:00:00

abstract：:The wide use of serotonin reuptake inhibitors and serotonin receptor agonists in anxiety disorders has suggested a key role for the modulatory neurotransmitter in anxiety. However, serotonin's specific role is still uncertain. This article reviews the literature concerning how and where serotonergic agents modulate an...

journal_title：Neuromolecular medicine

authors： Gordon JA,Hen R

更新日期：2004-01-01 00:00:00

abstract：:Cardiovascular diseases including hypertension, myocardial infarction, stroke, and heart failure continue to account for the majority of deaths in the developed world. Whilst the incidence of these clinical disorders does increase with age, outcomes in affected patients tend to be disproportionately adverse with advan...

journal_title：Neuromolecular medicine

authors： Kaye DM,Esler MD

更新日期：2008-01-01 00:00:00

abstract：:The high-metabolic demand of neurons and their reliance on glucose as an energy source places them at risk for dysfunction and death under conditions of metabolic and oxidative stress. Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins implicated in the regulation of mitochondrial membrane potential ...

journal_title：Neuromolecular medicine

authors： Liu D,Chan SL,de Souza-Pinto NC,Slevin JR,Wersto RP,Zhan M,Mustafa K,de Cabo R,Mattson MP

更新日期：2006-01-01 00:00:00

abstract：:A methylation-based EWAS on carefully phenotyped individuals with Parkinson's disease (PD) was conducted to reveal prioritised genes and pathways with statistically significant and sizable changes in PD and in the anxiety that often accompanies it. This was followed by subsequent replication of top-ranked CpG sites. U...

journal_title：Neuromolecular medicine

authors： Moore K,McKnight AJ,Craig D,O'Neill F

更新日期：2014-12-01 00:00:00

abstract：:Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...

journal_title：Neuromolecular medicine

authors： Buraczynska M,Zukowski P,Buraczynska K,Mozul S,Ksiazek A

更新日期：2011-12-01 00:00:00

abstract：:Phospholipids are the main constituents of brain membranes. Formation of new membranes requires that uridine, the omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA), and choline, the three circulating precursors of major phospholipids, interact via the Kennedy pathway. Supplementation of laboratory...

journal_title：Neuromolecular medicine

authors： Cansev M

更新日期：2016-09-01 00:00:00

abstract：:Schizophrenia is a complex psychiatric disorder characterized by memory impairments with delusions and hallucinations. Several investigations have focused on determining the association between NOS1 (nitric oxide synthase-1) polymorphisms and risk of schizophrenia (SZ). However, the association of rs2682826, rs3782206...

journal_title：Neuromolecular medicine

authors： Ahmed SSSJ,Akram Husain RS,Suresh Kumar,Ramakrishnan V

更新日期：2017-09-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy and related pathways have also been implicated in the etiology of ASD. We aimed to investigate autophagic markers by generating the transge...

journal_title：Neuromolecular medicine

authors： Dana H,Bayramov KK,Delibaşı N,Tahtasakal R,Bayramov R,Hamurcu Z,Sener EF

更新日期：2020-06-01 00:00:00