Decreased levels of circulating adiponectin in mild cognitive impairment and Alzheimer's disease.

abstract：:Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cy...

journal_title：Neuromolecular medicine

authors： Das DK,Mehta B,Menon SR,Raha S,Udani V

更新日期：2013-03-01 00:00:00

abstract：:The α-synuclein gene (SNCA) plays a major role in the aetiology of Lewy body disease (LBD) including Parkinson's disease (PD). Point mutations and genetic alterations causing elevated gene expression are causally linked to familial PD. To what extent epigenetic changes play a role in the regulation of α-synuclein expr...

journal_title：Neuromolecular medicine

authors： de Boni L,Tierling S,Roeber S,Walter J,Giese A,Kretzschmar HA

更新日期：2011-12-01 00:00:00

abstract：:The wide use of serotonin reuptake inhibitors and serotonin receptor agonists in anxiety disorders has suggested a key role for the modulatory neurotransmitter in anxiety. However, serotonin's specific role is still uncertain. This article reviews the literature concerning how and where serotonergic agents modulate an...

journal_title：Neuromolecular medicine

authors： Gordon JA,Hen R

更新日期：2004-01-01 00:00:00

abstract：:We have previously reported that mild traumatic brain injury (mTBI) induced cognitive deficits as well as apoptotic changes in the brains of mice. Apoptosis may be caused by severe, prolonged accumulation of misfolded proteins, and protein aggregation in the endoplasmic reticulum (ER stress). In an additional study, w...

journal_title：Neuromolecular medicine

authors： Rubovitch V,Barak S,Rachmany L,Goldstein RB,Zilberstein Y,Pick CG

更新日期：2015-03-01 00:00:00

abstract：:Accumulating studies have suggested the important role of microRNA (miRNA) in ischemic cerebral infarction. However, little is known of the modifying effect of miR-5787, a newly found miRNA, in ischemic cerebral infarction. We aim to elucidate the effect and underlying molecular mechanism of miR-5787 in the pathogenes...

journal_title：Neuromolecular medicine

authors： Bao Z,Zhang S,Li X

更新日期：2020-11-09 00:00:00

abstract：:A key neuropathological hallmark of Alzheimer's disease (AD) is the loss of neocortical and hippocampal synapses, which is closely correlated with the degree of memory impairment. Mutations in the genes encoding the amyloid precursorprotein (APP) and presenilins are responsible from some cases of early-onset autosomal...

journal_title：Neuromolecular medicine

authors： Chan SL,Furukawa K,Mattson MP

更新日期：2002-01-01 00:00:00

abstract：:A major component of green tea, a widely consumed beverage, is (-)-epigallocatechin gallate (EGCG), which has strong antioxidant properties. Our previous study has indicated that free radical production following rat traumatic brain injury (TBI) induces neural degeneration. In this study, we investigated the effects o...

journal_title：Neuromolecular medicine

authors： Itoh T,Imano M,Nishida S,Tsubaki M,Hashimoto S,Ito A,Satou T

更新日期：2011-12-01 00:00:00

abstract：:Classically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular...

journal_title：Neuromolecular medicine

authors： Easwaran TP,Lancki N,Henriquez M,Vortmeyer AO,Barbaro NM,Scholtens DM,Ahmed AU,Dey M

更新日期：2020-11-18 00:00:00

abstract：:Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism. Elevated plasma Hcy levels (> 15 µM) result in a condition called hyperhomocysteinemia (HHcy), which is an independent risk factor in the development of various neurodegenerative disorders. Reactive oxygen species (ROS) produced b...

journal_title：Neuromolecular medicine

authors： Kumar M,Sandhir R

更新日期：2018-12-01 00:00:00

abstract：:The frequent co-occurrence of autism spectrum disorders (ASD) and epilepsy, or paroxysmal EEG abnormalities, defines a condition termed autism-epilepsy phenotype (AEP). This condition results, in some cases , from dysfunctions of glial inwardly rectifying potassium channels (Kir), which are mainly expressed in astrocy...

journal_title：Neuromolecular medicine

authors： Marchese M,Valvo G,Moro F,Sicca F,Santorelli FM

更新日期：2016-03-01 00:00:00

abstract：:Danshensu (DSS) and tetramethylpyrazine (TMP) are active ingredients of Salvia miltiorrhiza Bge. and Ligusticum chuanxiong Hort that are widely used in oriental medicine. Structural combination of compounds with known biological activity may lead to the formation of a molecule with multiple properties or new function ...

journal_title：Neuromolecular medicine

authors： Hu S,Wang L,Mak S,Zhang Z,Xu D,Li H,Li Y,Hu Y,Lee SM,Wang Y,Han Y

更新日期：2016-12-01 00:00:00

abstract：:The cerebral ischemia is one of the most common diseases in the central nervous system that causes progressive disability or even death. In this connection, the inflammatory response mediated by the activated microglia is believed to play a central role in this pathogenesis. In the event of brain injury, activated mic...

journal_title：Neuromolecular medicine

authors： Yuan Y,Fang M,Wu CY,Ling EA

更新日期：2016-09-01 00:00:00

abstract：:Hypothalamic neuropeptide Y (NPY) and superoxide dismutase (SOD) have been reported to participate in the regulation of appetite-suppressing effect of phenylpropanolamine (PPA), a sympathomimetic agent. This study explored whether Y1 receptor (Y1R) and/or Y5 receptor (Y5R) was involved in this regulation. Wistar rats ...

journal_title：Neuromolecular medicine

authors： Hsieh YS,Kuo MH,Chen PN,Kuo DY

更新日期：2013-03-01 00:00:00

abstract：:Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...

journal_title：Neuromolecular medicine

authors： Buraczynska M,Zukowski P,Buraczynska K,Mozul S,Ksiazek A

更新日期：2011-12-01 00:00:00

abstract：:Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a genetic and early-onset neurodegenerative disorder characterized by iron accumulation in the basal ganglia. It is due to mutations in Pantothenate Kinase 2 (PANK2), an enzyme that catalyzes the phosphorylation of vitamin B5, first and essential step in coenz...

journal_title：Neuromolecular medicine

authors： Khatri D,Zizioli D,Trivedi A,Borsani G,Monti E,Finazzi D

更新日期：2019-06-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy and related pathways have also been implicated in the etiology of ASD. We aimed to investigate autophagic markers by generating the transge...

journal_title：Neuromolecular medicine

authors： Dana H,Bayramov KK,Delibaşı N,Tahtasakal R,Bayramov R,Hamurcu Z,Sener EF

更新日期：2020-06-01 00:00:00

abstract：:Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include stimulations coupled with rowing, cycling, assisted walking and other derivatives. In this review, we studied thirteen clinical rep...

journal_title：Neuromolecular medicine

authors： Luo S,Xu H,Zuo Y,Liu X,All AH

更新日期：2020-12-01 00:00:00

abstract：:Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individuals of Ashkenazi Jewish descent. The pathological and clinical manifestations of ...

journal_title：Neuromolecular medicine

authors： Rubin BY,Anderson SL

更新日期：2008-01-01 00:00:00

abstract：:Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...

journal_title：Neuromolecular medicine

authors： Kim J,Fann DY,Seet RC,Jo DG,Mattson MP,Arumugam TV

更新日期：2016-09-01 00:00:00

abstract：:There is evidence that chronic hyponatremia, even when mild, may cause neurological signs and symptoms. These have been traditionally associated with water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts neg...

journal_title：Neuromolecular medicine

authors： Benvenuti S,Deledda C,Luciani P,Modi G,Bossio A,Giuliani C,Fibbi B,Peri A

更新日期：2013-09-01 00:00:00

abstract：:He spent tens of thousands of hours peering through the oculars of a microscope at stained brain tissue sections from thousands of patients who died with or without a neurodegenerative disorder; most of those patients he had himself cared for and had removed and processed their brain tissues upon their death. His disc...

journal_title：Neuromolecular medicine

authors： Mattson MP

更新日期：2011-03-01 00:00:00

abstract：:Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...

journal_title：Neuromolecular medicine

authors： Villar-Menéndez I,Blanch M,Tyebji S,Pereira-Veiga T,Albasanz JL,Martín M,Ferrer I,Pérez-Navarro E,Barrachina M

更新日期：2013-06-01 00:00:00

abstract：:The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the clinical and pathological picture of Alzheimer's Disease. An apparent symptom ...

journal_title：Neuromolecular medicine

authors： Gleichmann M,Mattson MP

更新日期：2010-03-01 00:00:00

abstract：:Millions of individuals with active TB do not receive recommended treatments, and instead may use botanicals, or use botanicals concurrently with established treatments. Many botanicals protect against oxidative stress, but this can interfere with redox-dependent activation of isoniazid and other prodrugs used for pro...

journal_title：Neuromolecular medicine

authors： Folk WR,Smith A,Song H,Chuang D,Cheng J,Gu Z,Sun G

更新日期：2016-09-01 00:00:00

abstract：:Physical exercise has long been recognized as highly beneficial for brain and body health. The molecular mechanisms responsible for translation of exercise stimuli in the brain have claimed attention due to mounting evidence for the neuroprotective actions of the exercise and its positive effects in preventing both ag...

journal_title：Neuromolecular medicine

authors： Llorens-Martín M,Torres-Alemán I,Trejo JL

更新日期：2008-01-01 00:00:00

abstract：:There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner ...

journal_title：Neuromolecular medicine

authors： Kiechle T,Dedeoglu A,Kubilus J,Kowall NW,Beal MF,Friedlander RM,Hersch SM,Ferrante RJ

更新日期：2002-01-01 00:00:00

abstract：:Cardiovascular diseases including hypertension, myocardial infarction, stroke, and heart failure continue to account for the majority of deaths in the developed world. Whilst the incidence of these clinical disorders does increase with age, outcomes in affected patients tend to be disproportionately adverse with advan...

journal_title：Neuromolecular medicine

authors： Kaye DM,Esler MD

更新日期：2008-01-01 00:00:00

abstract：:Phospholipids are the main constituents of brain membranes. Formation of new membranes requires that uridine, the omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA), and choline, the three circulating precursors of major phospholipids, interact via the Kennedy pathway. Supplementation of laboratory...

journal_title：Neuromolecular medicine

authors： Cansev M

更新日期：2016-09-01 00:00:00

abstract：:Neurodegeneration is the main pathological correlate of accumulating disability in progressive stages of Multiple Sclerosis (MS), but both histologic and imaging studies detect significant tissue loss even in early disease. These observations raise the question as to whether neurodegeneration in MS is a primary mechan...

journal_title：Neuromolecular medicine

authors： Kalman B,Leist TP

更新日期：2003-01-01 00:00:00

abstract：:Hemorrhagic transformation (HT) of cerebral infarction is a common and serious occurrence following acute ischemic stroke. The expression of survivin, a member of the inhibitor of apoptosis protein family, has been shown to increase after cerebral ischemia. This protein has been mainly located at the microvasculature ...

journal_title：Neuromolecular medicine

authors： Mallolas J,Rodríguez R,Gubern C,Camós S,Serena J,Castellanos M

更新日期：2014-12-01 00:00:00