Abstract:
:Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore protein p62, with the RNA export protein Tap and with the exon-exon junction complex (EJC) proteins Y14-Mago. The interaction of Staufen2 with the Y14-Mago heterodimer seems to represent a highly conserved complex as the same proteins are involved in the Staufen-mediated localization of oskar mRNA in Drosophila oocytes. A pool of Staufen2 is present in neuronal nuclei and colocalizes to a large degree with p62 and partly with Tap, Y14, and Mago. We suggest a model whereby a set of conserved genes in the oskar mRNA export pathway may be recruited to direct a dendritic destination for mRNAs originating as a Staufen2 nuclear complex.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Monshausen M,Gehring NH,Kosik KSdoi
10.1385/NMM:6:2-3:127keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
127-44issue
2-3eissn
1535-1084issn
1559-1174pii
NMM:6:2-3:127journal_volume
6pub_type
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