Targeted Gene Resequencing (Astrochip) to Explore the Tripartite Synapse in Autism-Epilepsy Phenotype with Macrocephaly.

abstract：:Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individuals of Ashkenazi Jewish descent. The pathological and clinical manifestations of ...

journal_title：Neuromolecular medicine

authors： Rubin BY,Anderson SL

更新日期：2008-01-01 00:00:00

abstract：:Neuronal diseases, including retinal disorders, stroke, Alzheimer's disease, Parkinson's disease and spinal cord injury, affect a large number of people worldwide and cause heavy social and economic burdens. Although many efforts have been made by scientists and clinicians to develop novel drug and healthcare strategi...

journal_title：Neuromolecular medicine

authors： Xing X,Liu F,Xiao J,So KF

更新日期：2016-09-01 00:00:00

abstract：:Stroke remains a significant unmet clinical need with limited therapeutic options. The peculiar feature of ischemic stroke is the interruption in brain circulation, resulting in a cascade of detrimental cerebrovasculature alterations. Treatment strategies designed to maintain potency of the cerebrovasculature may prot...

journal_title：Neuromolecular medicine

authors： Pianta S,Lee JY,Tuazon JP,Castelli V,Mantohac LM,Tajiri N,Borlongan CV

更新日期：2019-12-01 00:00:00

abstract：:A number of studies have investigated the association between tumor necrosis factor (TNF)-α gene polymorphisms and ischemic stroke susceptibility. However, results of different individual studies are often inconsistent. To provide a more robust evaluation of the association between polymorphisms of the TNF-α gene and ...

journal_title：Neuromolecular medicine

authors： Niu YM,Weng H,Zhang C,Yuan RX,Yan JZ,Meng XY,Luo J

更新日期：2015-12-01 00:00:00

abstract：:Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cy...

journal_title：Neuromolecular medicine

authors： Das DK,Mehta B,Menon SR,Raha S,Udani V

更新日期：2013-03-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative motor disorder, marked by chronic progressive loss of neurons in the substantia nigra, thereby damaging purposeful control of movement. For decades, it was believed that PD was caused solely by environmental causes. However, the discovery of genetic factors...

journal_title：Neuromolecular medicine

authors： Cole NB,Murphy DD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Scutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in experimentally induced cerebral ischemia; however, the underlying mechanism for this has not been fully clarified. We sought to elucidate if scutellarin would exert its anti-i...

journal_title：Neuromolecular medicine

authors： Chen HL,Jia WJ,Li HE,Han H,Li F,Zhang XL,Li JJ,Yuan Y,Wu CY

更新日期：2020-06-01 00:00:00

abstract：:P-glycoprotein (P-gp), which is coded by the MDR1 gene, in the brain capillary endothelial cell limits the entry of many drugs including antipsychotics into the brain. The aim of this study is to examine whether a functional polymorphism, a C to T substitution at position 3435 in exon 26 of the MDR1 gene, is associate...

journal_title：Neuromolecular medicine

authors： Shinkai T,De Luca V,Utsunomiya K,Sakata S,Inoue Y,Fukunaka Y,Hwang R,Ohmori O,Kennedy JL,Nakamura J

更新日期：2008-01-01 00:00:00

abstract：:The high-metabolic demand of neurons and their reliance on glucose as an energy source places them at risk for dysfunction and death under conditions of metabolic and oxidative stress. Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins implicated in the regulation of mitochondrial membrane potential ...

journal_title：Neuromolecular medicine

authors： Liu D,Chan SL,de Souza-Pinto NC,Slevin JR,Wersto RP,Zhan M,Mustafa K,de Cabo R,Mattson MP

更新日期：2006-01-01 00:00:00

abstract：:He spent tens of thousands of hours peering through the oculars of a microscope at stained brain tissue sections from thousands of patients who died with or without a neurodegenerative disorder; most of those patients he had himself cared for and had removed and processed their brain tissues upon their death. His disc...

journal_title：Neuromolecular medicine

authors： Mattson MP

更新日期：2011-03-01 00:00:00

abstract：:It is an established fact that orexin plays an important role in regulating the reproductive axis and the secretions of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH). However, its precise cellular and molecular mechanisms are not fully recognized. Accordingly, the aim of the present study is to find o...

journal_title：Neuromolecular medicine

authors： Hosseini A,Khazali H

更新日期：2018-12-01 00:00:00

abstract：:The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the clinical and pathological picture of Alzheimer's Disease. An apparent symptom ...

journal_title：Neuromolecular medicine

authors： Gleichmann M,Mattson MP

更新日期：2010-03-01 00:00:00

abstract：:Hypothalamic neuropeptide Y (NPY) and superoxide dismutase (SOD) have been reported to participate in the regulation of appetite-suppressing effect of phenylpropanolamine (PPA), a sympathomimetic agent. This study explored whether Y1 receptor (Y1R) and/or Y5 receptor (Y5R) was involved in this regulation. Wistar rats ...

journal_title：Neuromolecular medicine

authors： Hsieh YS,Kuo MH,Chen PN,Kuo DY

更新日期：2013-03-01 00:00:00

abstract：:Cyclin H regulates cell cycle transitions; it always forms trimeric cyclin-dependent protein kinases (CDK)-activating kinase (CAK) complex with CDK7 and MAT1 that phosphorylates a threonine residue in the CDK2 T loop region. However, neither the expression nor function of cyclin H in the central nervous system (CNS) i...

journal_title：Neuromolecular medicine

authors： Wu G,Cao J,Peng C,Yang H,Cui Z,Zhao J,Wu Q,Han J,Li H,Gu X,Zhang F

更新日期：2011-09-01 00:00:00

abstract：:Despite the significant amount of experimental data available on trehalose, the molecular mechanism responsible for its intracellular stabilising properties has not emerged yet. The repair of cellular homeostasis in many protein-misfolding diseases by trehalose is credited to the disaccharide being an inducer of autop...

journal_title：Neuromolecular medicine

authors： Chaudhary RK,Kardani J,Singh K,Banerjee R,Roy I

更新日期：2014-06-01 00:00:00

abstract：:Hemorrhagic transformation (HT) of cerebral infarction is a common and serious occurrence following acute ischemic stroke. The expression of survivin, a member of the inhibitor of apoptosis protein family, has been shown to increase after cerebral ischemia. This protein has been mainly located at the microvasculature ...

journal_title：Neuromolecular medicine

authors： Mallolas J,Rodríguez R,Gubern C,Camós S,Serena J,Castellanos M

更新日期：2014-12-01 00:00:00

abstract：:Clathrin assembly proteins AP180 and CALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse. Although studies using several invertebrate model systems have indicated a role for AP180 in SV recycl...

journal_title：Neuromolecular medicine

authors： Petralia RS,Wang YX,Indig FE,Bushlin I,Wu F,Mattson MP,Yao PJ

更新日期：2013-03-01 00:00:00

abstract：:Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy, regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and regulating cell death. Increasing evidence suggests that mitochondria play a central role in aging and in neurodegenerative diseases...

journal_title：Neuromolecular medicine

authors： Reddy PH

更新日期：2008-01-01 00:00:00

abstract：:Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their...

journal_title：Neuromolecular medicine

authors： Korn T,Rao M,Magnus T

更新日期：2007-01-01 00:00:00

abstract：:The gene encoding alpha-T-catenin, CTNNA3, is positioned within a region on chromosome 10, showing strong evidence of linkage to Alzheimer's disease (AD), and is therefore a good positional candidate gene for this disorder. We have demonstrated that alpha-T-catenin is expressed in human brain, and like other alpha-cat...

journal_title：Neuromolecular medicine

authors： Busby V,Goossens S,Nowotny P,Hamilton G,Smemo S,Harold D,Turic D,Jehu L,Myers A,Womick M,Woo D,Compton D,Doil LM,Tacey KM,Lau KF,Al-Saraj S,Killick R,Pickering-Brown S,Moore P,Hollingworth P,Archer N,Foy C,Wal

更新日期：2004-01-01 00:00:00

abstract：:Epidemiological studies demonstrate that pain frequently occurs comorbid with depression. Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cor...

journal_title：Neuromolecular medicine

authors： Liu SB,Zhao R,Li XS,Guo HJ,Tian Z,Zhang N,Gao GD,Zhao MG

更新日期：2014-06-01 00:00:00

abstract：:Certain serine proteases from the circulation (e.g., coagulation factors), inflammatory cells (e.g., mast-cell tryptase, neutrophil proteinase 3), and from many other cell types (e.g., trypsins) can specifically signal to cells by cleaving protease-activated receptors (PARs), a family of four G protein-coupled recepto...

journal_title：Neuromolecular medicine

authors： Saito T,Bunnett NW

更新日期：2005-01-01 00:00:00

abstract：:Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...

journal_title：Neuromolecular medicine

authors： Kim J,Fann DY,Seet RC,Jo DG,Mattson MP,Arumugam TV

更新日期：2016-09-01 00:00:00

abstract：:Parkinson' disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non-motor sympto...

journal_title：Neuromolecular medicine

authors： Sanjari Moghaddam H,Valitabar Z,Ashraf-Ganjouei A,Mojtahed Zadeh M,Ghazi Sherbaf F,Aarabi MH

更新日期：2018-09-01 00:00:00

abstract：:Selective degeneration and death of motor neurons in SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) is accompanied by axonal disorganization and reduced slow axonal transport in the three most frequently used mouse models of mutant SOD1-mediated ALS. To test whether suppression of axonal degeneration (freque...

journal_title：Neuromolecular medicine

authors： Vande Velde C,Garcia ML,Yin X,Trapp BD,Cleveland DW

更新日期：2004-01-01 00:00:00

abstract：:Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...

journal_title：Neuromolecular medicine

authors： Villar-Menéndez I,Blanch M,Tyebji S,Pereira-Veiga T,Albasanz JL,Martín M,Ferrer I,Pérez-Navarro E,Barrachina M

更新日期：2013-06-01 00:00:00

abstract：:Glioma ranks first among the aggressive brain tumors all over the world. LncRNA LINC00689 has been confirmed to play key roles in the progression of cancers, and LINC00689 was upregulated in glioma. However, the biological function of LINC00689 in glioma is unclear. qRT-PCR was applied to detect the expressions of LIN...

journal_title：Neuromolecular medicine

authors： Zhan WL,Gao N,Tu GL,Tang H,Gao L,Xia Y

更新日期：2021-01-03 00:00:00

abstract：:The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence in the general population is approximately 25%. Central fat accumulation and i...

journal_title：Neuromolecular medicine

authors： Tentolouris N,Argyrakopoulou G,Katsilambros N

更新日期：2008-01-01 00:00:00

abstract：:Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include stimulations coupled with rowing, cycling, assisted walking and other derivatives. In this review, we studied thirteen clinical rep...

journal_title：Neuromolecular medicine

authors： Luo S,Xu H,Zuo Y,Liu X,All AH

更新日期：2020-12-01 00:00:00

abstract：:A key neuropathological hallmark of Alzheimer's disease (AD) is the loss of neocortical and hippocampal synapses, which is closely correlated with the degree of memory impairment. Mutations in the genes encoding the amyloid precursorprotein (APP) and presenilins are responsible from some cases of early-onset autosomal...

journal_title：Neuromolecular medicine

authors： Chan SL,Furukawa K,Mattson MP

更新日期：2002-01-01 00:00:00