A Review of Functional Electrical Stimulation Treatment in Spinal Cord Injury.

abstract：:Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with fir...

journal_title：Neuromolecular medicine

authors： Ye Z,Zhang H,Sun L,Cai H,Hao Y,Xu Z,Zhang Z,Liu X

更新日期：2018-06-01 00:00:00

abstract：:A methylation-based EWAS on carefully phenotyped individuals with Parkinson's disease (PD) was conducted to reveal prioritised genes and pathways with statistically significant and sizable changes in PD and in the anxiety that often accompanies it. This was followed by subsequent replication of top-ranked CpG sites. U...

journal_title：Neuromolecular medicine

authors： Moore K,McKnight AJ,Craig D,O'Neill F

更新日期：2014-12-01 00:00:00

abstract：:Vitamin D deficiency is suggested to be associated with Parkinson's disease (PD). Our aim was to investigate the serum 25-hydroxyvitamin D3 (25OHD) levels of PD patients in Turkish cohort, to investigate any association of vitamin D binding protein (GC) genotypes with PD due to the significant role of GC in vitamin D ...

journal_title：Neuromolecular medicine

authors： Gezen-Ak D,Alaylıoğlu M,Genç G,Gündüz A,Candaş E,Bilgiç B,Atasoy İL,Apaydın H,Kızıltan G,Gürvit H,Hanağası H,Ertan S,Yılmazer S,Dursun E

更新日期：2017-03-01 00:00:00

abstract：:There is evidence that chronic hyponatremia, even when mild, may cause neurological signs and symptoms. These have been traditionally associated with water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts neg...

journal_title：Neuromolecular medicine

authors： Benvenuti S,Deledda C,Luciani P,Modi G,Bossio A,Giuliani C,Fibbi B,Peri A

更新日期：2013-09-01 00:00:00

abstract：:Hereditary sensory and autonomic neuropathy 1 (HSAN1) is an autosomal dominant disorder that can be caused by variants in SPTLC1 or SPTLC2, encoding subunits of serine palmitoyl-CoA transferase. Disease variants alter the enzyme's substrate specificity and lead to accumulation of neurotoxic 1-deoxysphingolipids. We de...

journal_title：Neuromolecular medicine

authors： Suriyanarayanan S,Auranen M,Toppila J,Paetau A,Shcherbii M,Palin E,Wei Y,Lohioja T,Schlotter-Weigel B,Schön U,Abicht A,Rautenstrauss B,Tyynismaa H,Walter MC,Hornemann T,Ylikallio E

更新日期：2016-03-01 00:00:00

abstract：:Abnormal interactions and misfolding of synaptic proteins in the nervous system are being extensively explored as important pathogenic events resulting in neurodegeneration in various neurological disorders. These include Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). In AD, m...

journal_title：Neuromolecular medicine

authors： Hashimoto M,Rockenstein E,Crews L,Masliah E

更新日期：2003-01-01 00:00:00

abstract：:It is an established fact that orexin plays an important role in regulating the reproductive axis and the secretions of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH). However, its precise cellular and molecular mechanisms are not fully recognized. Accordingly, the aim of the present study is to find o...

journal_title：Neuromolecular medicine

authors： Hosseini A,Khazali H

更新日期：2018-12-01 00:00:00

abstract：:Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism. Elevated plasma Hcy levels (> 15 µM) result in a condition called hyperhomocysteinemia (HHcy), which is an independent risk factor in the development of various neurodegenerative disorders. Reactive oxygen species (ROS) produced b...

journal_title：Neuromolecular medicine

authors： Kumar M,Sandhir R

更新日期：2018-12-01 00:00:00

abstract：:Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their...

journal_title：Neuromolecular medicine

authors： Korn T,Rao M,Magnus T

更新日期：2007-01-01 00:00:00

abstract：:A number of studies have investigated the association between tumor necrosis factor (TNF)-α gene polymorphisms and ischemic stroke susceptibility. However, results of different individual studies are often inconsistent. To provide a more robust evaluation of the association between polymorphisms of the TNF-α gene and ...

journal_title：Neuromolecular medicine

authors： Niu YM,Weng H,Zhang C,Yuan RX,Yan JZ,Meng XY,Luo J

更新日期：2015-12-01 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is a behavioral diagnosis based on the presence of developmentally inappropriate levels of impulsivity, overactivity, and inattentiveness. It is a familial condition with a complex pattern of inheritance. Variation of several genes involved in the regulation of dopamine,...

journal_title：Neuromolecular medicine

authors： Kuntsi J,McLoughlin G,Asherson P

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Scutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in experimentally induced cerebral ischemia; however, the underlying mechanism for this has not been fully clarified. We sought to elucidate if scutellarin would exert its anti-i...

journal_title：Neuromolecular medicine

authors： Chen HL,Jia WJ,Li HE,Han H,Li F,Zhang XL,Li JJ,Yuan Y,Wu CY

更新日期：2020-06-01 00:00:00

abstract：:Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore prot...

journal_title：Neuromolecular medicine

authors： Monshausen M,Gehring NH,Kosik KS

更新日期：2004-01-01 00:00:00

abstract：:Sphingosine 1-phosphates (S1Ps) are bioactive lipids that mediate a diverse range of effects through the activation of cognate receptors, S1P1-S1P5. Scrutiny of S1P-regulated pathways over the past three decades has identified important and occasionally counteracting functions in the brain and cerebrovascular system. ...

journal_title：Neuromolecular medicine

authors： Chua XY,Ho LTY,Xiang P,Chew WS,Lam BWS,Chen CP,Ong WY,Lai MKP,Herr DR

更新日期：2020-11-12 00:00:00

abstract：:The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence in the general population is approximately 25%. Central fat accumulation and i...

journal_title：Neuromolecular medicine

authors： Tentolouris N,Argyrakopoulou G,Katsilambros N

更新日期：2008-01-01 00:00:00

abstract：:Epidemiological studies demonstrate that pain frequently occurs comorbid with depression. Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cor...

journal_title：Neuromolecular medicine

authors： Liu SB,Zhao R,Li XS,Guo HJ,Tian Z,Zhang N,Gao GD,Zhao MG

更新日期：2014-06-01 00:00:00

abstract：:Physical exercise has long been recognized as highly beneficial for brain and body health. The molecular mechanisms responsible for translation of exercise stimuli in the brain have claimed attention due to mounting evidence for the neuroprotective actions of the exercise and its positive effects in preventing both ag...

journal_title：Neuromolecular medicine

authors： Llorens-Martín M,Torres-Alemán I,Trejo JL

更新日期：2008-01-01 00:00:00

abstract：:T-cells directed to self-antigens ("autoimmune" T-cells) have traditionally been perceived as tending to attack the body's own tissues, and likely to exert their destructive effects unless they undergo deletion in the thymus during ontogeny. Naturally occurring CD4+CD25+ regulatory T-cells were viewed as thymus-derive...

journal_title：Neuromolecular medicine

authors： Kipnis J,Schwartz M

更新日期：2005-01-01 00:00:00

abstract：:We have previously reported that mild traumatic brain injury (mTBI) induced cognitive deficits as well as apoptotic changes in the brains of mice. Apoptosis may be caused by severe, prolonged accumulation of misfolded proteins, and protein aggregation in the endoplasmic reticulum (ER stress). In an additional study, w...

journal_title：Neuromolecular medicine

authors： Rubovitch V,Barak S,Rachmany L,Goldstein RB,Zilberstein Y,Pick CG

更新日期：2015-03-01 00:00:00

abstract：:Hypothalamic neuropeptide Y (NPY) and superoxide dismutase (SOD) have been reported to participate in the regulation of appetite-suppressing effect of phenylpropanolamine (PPA), a sympathomimetic agent. This study explored whether Y1 receptor (Y1R) and/or Y5 receptor (Y5R) was involved in this regulation. Wistar rats ...

journal_title：Neuromolecular medicine

authors： Hsieh YS,Kuo MH,Chen PN,Kuo DY

更新日期：2013-03-01 00:00:00

abstract：:Substantial evidence indicates bioenergetic dysfunction and mitochondrial impairment contribute either directly and/or indirectly to the pathogenesis of numerous neurodegenerative disorders. Treatment paradigms aimed at ameliorating this cellular energy deficit and/or improving mitochondrial function in these neurodeg...

journal_title：Neuromolecular medicine

authors： Adhihetty PJ,Beal MF

更新日期：2008-01-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy and related pathways have also been implicated in the etiology of ASD. We aimed to investigate autophagic markers by generating the transge...

journal_title：Neuromolecular medicine

authors： Dana H,Bayramov KK,Delibaşı N,Tahtasakal R,Bayramov R,Hamurcu Z,Sener EF

更新日期：2020-06-01 00:00:00

abstract：:Accumulating studies have suggested the important role of microRNA (miRNA) in ischemic cerebral infarction. However, little is known of the modifying effect of miR-5787, a newly found miRNA, in ischemic cerebral infarction. We aim to elucidate the effect and underlying molecular mechanism of miR-5787 in the pathogenes...

journal_title：Neuromolecular medicine

authors： Bao Z,Zhang S,Li X

更新日期：2020-11-09 00:00:00

abstract：:There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner ...

journal_title：Neuromolecular medicine

authors： Kiechle T,Dedeoglu A,Kubilus J,Kowall NW,Beal MF,Friedlander RM,Hersch SM,Ferrante RJ

更新日期：2002-01-01 00:00:00

abstract：:The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the clinical and pathological picture of Alzheimer's Disease. An apparent symptom ...

journal_title：Neuromolecular medicine

authors： Gleichmann M,Mattson MP

更新日期：2010-03-01 00:00:00

abstract：:Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...

journal_title：Neuromolecular medicine

authors： Villar-Menéndez I,Blanch M,Tyebji S,Pereira-Veiga T,Albasanz JL,Martín M,Ferrer I,Pérez-Navarro E,Barrachina M

更新日期：2013-06-01 00:00:00

abstract：:The X-linked form of Charcot-Marie-Tooth disease (CMT1X) is the second most common molecularly designated form of hereditary motor and sensory neuropathy. The clinical phenotype is characterized by progressive distal muscle atrophy and weakness, areflexia, and variable sensory abnormalities. Affected males have modera...

journal_title：Neuromolecular medicine

authors： Kleopa KA,Scherer SS

更新日期：2006-01-01 00:00:00

abstract：:More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT...

journal_title：Neuromolecular medicine

authors： Shy ME

更新日期：2006-01-01 00:00:00

abstract：:Hemorrhagic transformation (HT) of cerebral infarction is a common and serious occurrence following acute ischemic stroke. The expression of survivin, a member of the inhibitor of apoptosis protein family, has been shown to increase after cerebral ischemia. This protein has been mainly located at the microvasculature ...

journal_title：Neuromolecular medicine

authors： Mallolas J,Rodríguez R,Gubern C,Camós S,Serena J,Castellanos M

更新日期：2014-12-01 00:00:00

abstract：:Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...

journal_title：Neuromolecular medicine

authors： Buraczynska M,Zukowski P,Buraczynska K,Mozul S,Ksiazek A

更新日期：2011-12-01 00:00:00