Abstract：
:The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the clinical and pathological picture of Alzheimer's Disease. An apparent symptom of altered neuronal network activity in Alzheimer's Disease is an increased frequency in epileptic seizures that is observed both in human patients and in mouse models of Alzheimer's Disease. A root cause for altered network activity may be amyloid beta itself by its ability to alter synaptic (glutamatergic) transmission and to impair the induction of long-term potentiation. It is on this aspect of Alzheimer's Disease research that the current issue of NeuroMolecular Medicine will focus. Reviews will discuss the basic research and clinical aspects of the issue such as the effects of amyloid beta on synaptic transmission and neuronal networks, as well as the changes in functional MRI activation patterns observed in early stages of Alzheimer's Disease and the frequency and relevance of epileptic seizures in Alzheimer's Disease patients.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Gleichmann M,Mattson MPdoi
10.1007/s12017-009-8100-3subject
Has Abstractpub_date
2010-03-01 00:00:00pages
44-7issue
1eissn
1535-1084issn
1559-1174journal_volume
12pub_type
杂志文章,评审abstract：:Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism. Elevated plasma Hcy levels (> 15 µM) result in a condition called hyperhomocysteinemia (HHcy), which is an independent risk factor in the development of various neurodegenerative disorders. Reactive oxygen species (ROS) produced b...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-018-8505-y
更新日期：2018-12-01 00:00:00
abstract：:Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cy...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-012-8212-z
更新日期：2013-03-01 00:00:00
abstract：:Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy, regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and regulating cell death. Increasing evidence suggests that mitochondria play a central role in aging and in neurodegenerative diseases...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-008-8044-z
更新日期：2008-01-01 00:00:00
abstract：:Danshensu (DSS) and tetramethylpyrazine (TMP) are active ingredients of Salvia miltiorrhiza Bge. and Ligusticum chuanxiong Hort that are widely used in oriental medicine. Structural combination of compounds with known biological activity may lead to the formation of a molecule with multiple properties or new function ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-016-8399-5
更新日期：2016-12-01 00:00:00
abstract：:Clathrin assembly proteins AP180 and CALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse. Although studies using several invertebrate model systems have indicated a role for AP180 in SV recycl...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-012-8194-x
更新日期：2013-03-01 00:00:00
abstract：:Epileptic seizures have long been recognised as a complication of the clinical syndrome of Alzheimer's disease, particularly in advanced disease, but have hitherto been viewed essentially as epiphenomena of the neurodegenerative process. Progress with animal models of Alzheimer's disease has suggested that this view m...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-009-8076-z
更新日期：2010-03-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects motor neurons and descending motor tracts of the CNS. We have evaluated the CNS of a murine model of familial ALS based on the over-expression of mutant human superoxide dismutase (mSOD; G93A) using magnetic resonance microscopy ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-007-8002-1
更新日期：2007-01-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. Gary S. Laco should not be listed as an author in the author group. ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12017-020-08593-4
更新日期：2020-06-01 00:00:00
abstract：:Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individuals of Ashkenazi Jewish descent. The pathological and clinical manifestations of ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-007-8019-5
更新日期：2008-01-01 00:00:00
abstract：:Aluminum (Al) is an environmental neurotoxin that affects cerebral functions and causes health complications. However, the role of Al in arbitrating glia homeostasis and pathophysiology remains obscure. Astrocyte, microglia activation (reactive gliosis), and associated inflammatory events play a decisive role in neuro...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-012-8210-1
更新日期：2013-03-01 00:00:00
abstract：:More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/nmm:8:1-2:255
更新日期：2006-01-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy and related pathways have also been implicated in the etiology of ASD. We aimed to investigate autophagic markers by generating the transge...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08579-x
更新日期：2020-06-01 00:00:00
abstract：:A major component of green tea, a widely consumed beverage, is (-)-epigallocatechin gallate (EGCG), which has strong antioxidant properties. Our previous study has indicated that free radical production following rat traumatic brain injury (TBI) induces neural degeneration. In this study, we investigated the effects o...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-011-8162-x
更新日期：2011-12-01 00:00:00
abstract：:There is evidence that chronic hyponatremia, even when mild, may cause neurological signs and symptoms. These have been traditionally associated with water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts neg...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-013-8235-0
更新日期：2013-09-01 00:00:00
abstract：:Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder characterized by progressive cerebellar ataxia and epilepsy. The disease is caused by a pentanucleotide ATTCT expansion in intron 9 of the ATXN10 gene on chromosome 22q13.3. SCA10 has shown a geographical distribution throughout...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-017-8464-8
更新日期：2017-12-01 00:00:00
abstract：:Despite the significant amount of experimental data available on trehalose, the molecular mechanism responsible for its intracellular stabilising properties has not emerged yet. The repair of cellular homeostasis in many protein-misfolding diseases by trehalose is credited to the disaccharide being an inducer of autop...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-013-8275-5
更新日期：2014-06-01 00:00:00
abstract：:Neuronal diseases, including retinal disorders, stroke, Alzheimer's disease, Parkinson's disease and spinal cord injury, affect a large number of people worldwide and cause heavy social and economic burdens. Although many efforts have been made by scientists and clinicians to develop novel drug and healthcare strategi...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8393-y
更新日期：2016-09-01 00:00:00
abstract：:Millions of individuals with active TB do not receive recommended treatments, and instead may use botanicals, or use botanicals concurrently with established treatments. Many botanicals protect against oxidative stress, but this can interfere with redox-dependent activation of isoniazid and other prodrugs used for pro...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8402-1
更新日期：2016-09-01 00:00:00
abstract：:Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8403-0
更新日期：2016-09-01 00:00:00
abstract：:Stroke remains a significant unmet clinical need with limited therapeutic options. The peculiar feature of ischemic stroke is the interruption in brain circulation, resulting in a cascade of detrimental cerebrovasculature alterations. Treatment strategies designed to maintain potency of the cerebrovasculature may prot...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08533-x
更新日期：2019-12-01 00:00:00
abstract：:A key neuropathological hallmark of Alzheimer's disease (AD) is the loss of neocortical and hippocampal synapses, which is closely correlated with the degree of memory impairment. Mutations in the genes encoding the amyloid precursorprotein (APP) and presenilins are responsible from some cases of early-onset autosomal...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/NMM:2:2:167
更新日期：2002-01-01 00:00:00
abstract：:The wide use of serotonin reuptake inhibitors and serotonin receptor agonists in anxiety disorders has suggested a key role for the modulatory neurotransmitter in anxiety. However, serotonin's specific role is still uncertain. This article reviews the literature concerning how and where serotonergic agents modulate an...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/NMM:5:1:027
更新日期：2004-01-01 00:00:00
abstract：:It is an established fact that orexin plays an important role in regulating the reproductive axis and the secretions of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH). However, its precise cellular and molecular mechanisms are not fully recognized. Accordingly, the aim of the present study is to find o...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-018-8506-x
更新日期：2018-12-01 00:00:00
abstract：:The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence in the general population is approximately 25%. Central fat accumulation and i...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-008-8022-5
更新日期：2008-01-01 00:00:00
abstract：:We have previously reported that mild traumatic brain injury (mTBI) induced cognitive deficits as well as apoptotic changes in the brains of mice. Apoptosis may be caused by severe, prolonged accumulation of misfolded proteins, and protein aggregation in the endoplasmic reticulum (ER stress). In an additional study, w...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-015-8340-3
更新日期：2015-03-01 00:00:00
abstract：:Cardiovascular diseases including hypertension, myocardial infarction, stroke, and heart failure continue to account for the majority of deaths in the developed world. Whilst the incidence of these clinical disorders does increase with age, outcomes in affected patients tend to be disproportionately adverse with advan...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-008-8034-1
更新日期：2008-01-01 00:00:00
abstract：:Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study w...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-011-8158-6
更新日期：2011-12-01 00:00:00
abstract：:The present study demonstrates the efficacies of synthetic 1,8-cineole and an 1,8-cineole-rich supercritical carbon dioxide (SC-CO2) extract of small cardamom seeds in preventing oligomerization of amyloid beta peptide (Aβ42) and inhibiting iron-dependent oxyradical production in vitro. The oligomerization of Aβ42 was...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08574-2
更新日期：2020-03-01 00:00:00
abstract：:Reperfusion after cerebral ischemia causes additional ischemic injuries due to sudden recovery of blood supply. It usually produces excessive reactive species, mitochondrial dysfunction, oxidative stress, and cell apoptosis. Our study is designed to examine the role of miR-421 antagomir in cerebral ischemia/reperfusio...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-020-08600-8
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Scutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in experimentally induced cerebral ischemia; however, the underlying mechanism for this has not been fully clarified. We sought to elucidate if scutellarin would exert its anti-i...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08582-2
更新日期：2020-06-01 00:00:00
