abstract：:Glioma ranks first among the aggressive brain tumors all over the world. LncRNA LINC00689 has been confirmed to play key roles in the progression of cancers, and LINC00689 was upregulated in glioma. However, the biological function of LINC00689 in glioma is unclear. qRT-PCR was applied to detect the expressions of LIN...

journal_title：Neuromolecular medicine

authors： Zhan WL,Gao N,Tu GL,Tang H,Gao L,Xia Y

更新日期：2021-01-03 00:00:00

abstract：:Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include stimulations coupled with rowing, cycling, assisted walking and other derivatives. In this review, we studied thirteen clinical rep...

journal_title：Neuromolecular medicine

authors： Luo S,Xu H,Zuo Y,Liu X,All AH

更新日期：2020-12-01 00:00:00

abstract：:Classically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular...

journal_title：Neuromolecular medicine

authors： Easwaran TP,Lancki N,Henriquez M,Vortmeyer AO,Barbaro NM,Scholtens DM,Ahmed AU,Dey M

更新日期：2020-11-18 00:00:00

abstract：:Sphingosine 1-phosphates (S1Ps) are bioactive lipids that mediate a diverse range of effects through the activation of cognate receptors, S1P1-S1P5. Scrutiny of S1P-regulated pathways over the past three decades has identified important and occasionally counteracting functions in the brain and cerebrovascular system. ...

journal_title：Neuromolecular medicine

authors： Chua XY,Ho LTY,Xiang P,Chew WS,Lam BWS,Chen CP,Ong WY,Lai MKP,Herr DR

更新日期：2020-11-12 00:00:00

abstract：:Accumulating studies have suggested the important role of microRNA (miRNA) in ischemic cerebral infarction. However, little is known of the modifying effect of miR-5787, a newly found miRNA, in ischemic cerebral infarction. We aim to elucidate the effect and underlying molecular mechanism of miR-5787 in the pathogenes...

journal_title：Neuromolecular medicine

authors： Bao Z,Zhang S,Li X

更新日期：2020-11-09 00:00:00

abstract：:Reperfusion after cerebral ischemia causes additional ischemic injuries due to sudden recovery of blood supply. It usually produces excessive reactive species, mitochondrial dysfunction, oxidative stress, and cell apoptosis. Our study is designed to examine the role of miR-421 antagomir in cerebral ischemia/reperfusio...

journal_title：Neuromolecular medicine

authors： Yue Y,Zhao H,Yue Y,Zhang Y,Wei W

更新日期：2020-09-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy and related pathways have also been implicated in the etiology of ASD. We aimed to investigate autophagic markers by generating the transge...

journal_title：Neuromolecular medicine

authors： Dana H,Bayramov KK,Delibaşı N,Tahtasakal R,Bayramov R,Hamurcu Z,Sener EF

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Scutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in experimentally induced cerebral ischemia; however, the underlying mechanism for this has not been fully clarified. We sought to elucidate if scutellarin would exert its anti-i...

journal_title：Neuromolecular medicine

authors： Chen HL,Jia WJ,Li HE,Han H,Li F,Zhang XL,Li JJ,Yuan Y,Wu CY

更新日期：2020-06-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. Gary S. Laco should not be listed as an author in the author group. ...

journal_title：Neuromolecular medicine

authors： Emmerich T,Abdullah L,Ojo J,Mouzon B,Nguyen T,Crynen G,Evans JE,Reed J,Mullan M,Crawford F

更新日期：2020-06-01 00:00:00

abstract：:The present study demonstrates the efficacies of synthetic 1,8-cineole and an 1,8-cineole-rich supercritical carbon dioxide (SC-CO2) extract of small cardamom seeds in preventing oligomerization of amyloid beta peptide (Aβ42) and inhibiting iron-dependent oxyradical production in vitro. The oligomerization of Aβ42 was...

journal_title：Neuromolecular medicine

authors： Paul K,Ganguly U,Chakrabarti S,Bhattacharjee P

更新日期：2020-03-01 00:00:00

abstract：:Stroke remains a significant unmet clinical need with limited therapeutic options. The peculiar feature of ischemic stroke is the interruption in brain circulation, resulting in a cascade of detrimental cerebrovasculature alterations. Treatment strategies designed to maintain potency of the cerebrovasculature may prot...

journal_title：Neuromolecular medicine

authors： Pianta S,Lee JY,Tuazon JP,Castelli V,Mantohac LM,Tajiri N,Borlongan CV

更新日期：2019-12-01 00:00:00

abstract：:Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a genetic and early-onset neurodegenerative disorder characterized by iron accumulation in the basal ganglia. It is due to mutations in Pantothenate Kinase 2 (PANK2), an enzyme that catalyzes the phosphorylation of vitamin B5, first and essential step in coenz...

journal_title：Neuromolecular medicine

authors： Khatri D,Zizioli D,Trivedi A,Borsani G,Monti E,Finazzi D

更新日期：2019-06-01 00:00:00

abstract：:It is an established fact that orexin plays an important role in regulating the reproductive axis and the secretions of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH). However, its precise cellular and molecular mechanisms are not fully recognized. Accordingly, the aim of the present study is to find o...

journal_title：Neuromolecular medicine

authors： Hosseini A,Khazali H

更新日期：2018-12-01 00:00:00

abstract：:Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism. Elevated plasma Hcy levels (> 15 µM) result in a condition called hyperhomocysteinemia (HHcy), which is an independent risk factor in the development of various neurodegenerative disorders. Reactive oxygen species (ROS) produced b...

journal_title：Neuromolecular medicine

authors： Kumar M,Sandhir R

更新日期：2018-12-01 00:00:00

abstract：:GBM is the highest incidence in primary intracranial malignancy, and it remains poor prognosis even though the patient is gave standard treatment. Despite decades of intense research, the complex biology of GBM remains elusive. In view of eight hallmarks of cancer which were proposed in 2011, studies related to the ei...

journal_title：Neuromolecular medicine

authors： Yu W,Liang S,Zhang C

更新日期：2018-12-01 00:00:00

abstract：:Parkinson' disease (PD) is characterized by motor symptoms including bradykinesia, resting tremor, postural instability, and rigidity and non-motor symptoms such as cognitive impairment, sleep disorder, and depression. Neuroinflammation has been recently implicated in pathophysiology of both motor and non-motor sympto...

journal_title：Neuromolecular medicine

authors： Sanjari Moghaddam H,Valitabar Z,Ashraf-Ganjouei A,Mojtahed Zadeh M,Ghazi Sherbaf F,Aarabi MH

更新日期：2018-09-01 00:00:00

abstract：:Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with fir...

journal_title：Neuromolecular medicine

authors： Ye Z,Zhang H,Sun L,Cai H,Hao Y,Xu Z,Zhang Z,Liu X

更新日期：2018-06-01 00:00:00

abstract：:Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder characterized by progressive cerebellar ataxia and epilepsy. The disease is caused by a pentanucleotide ATTCT expansion in intron 9 of the ATXN10 gene on chromosome 22q13.3. SCA10 has shown a geographical distribution throughout...

journal_title：Neuromolecular medicine

authors： Bampi GB,Bisso-Machado R,Hünemeier T,Gheno TC,Furtado GV,Veliz-Otani D,Cornejo-Olivas M,Mazzeti P,Bortolini MC,Jardim LB,Saraiva-Pereira ML,Rede Neurogenetica.

更新日期：2017-12-01 00:00:00

abstract：:Schizophrenia is a complex psychiatric disorder characterized by memory impairments with delusions and hallucinations. Several investigations have focused on determining the association between NOS1 (nitric oxide synthase-1) polymorphisms and risk of schizophrenia (SZ). However, the association of rs2682826, rs3782206...

journal_title：Neuromolecular medicine

authors： Ahmed SSSJ,Akram Husain RS,Suresh Kumar,Ramakrishnan V

更新日期：2017-09-01 00:00:00

abstract：:Vitamin D deficiency is suggested to be associated with Parkinson's disease (PD). Our aim was to investigate the serum 25-hydroxyvitamin D3 (25OHD) levels of PD patients in Turkish cohort, to investigate any association of vitamin D binding protein (GC) genotypes with PD due to the significant role of GC in vitamin D ...

journal_title：Neuromolecular medicine

authors： Gezen-Ak D,Alaylıoğlu M,Genç G,Gündüz A,Candaş E,Bilgiç B,Atasoy İL,Apaydın H,Kızıltan G,Gürvit H,Hanağası H,Ertan S,Yılmazer S,Dursun E

更新日期：2017-03-01 00:00:00

abstract：:Danshensu (DSS) and tetramethylpyrazine (TMP) are active ingredients of Salvia miltiorrhiza Bge. and Ligusticum chuanxiong Hort that are widely used in oriental medicine. Structural combination of compounds with known biological activity may lead to the formation of a molecule with multiple properties or new function ...

journal_title：Neuromolecular medicine

authors： Hu S,Wang L,Mak S,Zhang Z,Xu D,Li H,Li Y,Hu Y,Lee SM,Wang Y,Han Y

更新日期：2016-12-01 00:00:00

abstract：:Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...

journal_title：Neuromolecular medicine

authors： Kim J,Fann DY,Seet RC,Jo DG,Mattson MP,Arumugam TV

更新日期：2016-09-01 00:00:00

abstract：:Phospholipids are the main constituents of brain membranes. Formation of new membranes requires that uridine, the omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA), and choline, the three circulating precursors of major phospholipids, interact via the Kennedy pathway. Supplementation of laboratory...

journal_title：Neuromolecular medicine

authors： Cansev M

更新日期：2016-09-01 00:00:00

abstract：:The cerebral ischemia is one of the most common diseases in the central nervous system that causes progressive disability or even death. In this connection, the inflammatory response mediated by the activated microglia is believed to play a central role in this pathogenesis. In the event of brain injury, activated mic...

journal_title：Neuromolecular medicine

authors： Yuan Y,Fang M,Wu CY,Ling EA

更新日期：2016-09-01 00:00:00

abstract：:Millions of individuals with active TB do not receive recommended treatments, and instead may use botanicals, or use botanicals concurrently with established treatments. Many botanicals protect against oxidative stress, but this can interfere with redox-dependent activation of isoniazid and other prodrugs used for pro...

journal_title：Neuromolecular medicine

authors： Folk WR,Smith A,Song H,Chuang D,Cheng J,Gu Z,Sun G

更新日期：2016-09-01 00:00:00

abstract：:Clinacanthus nutans Lindau (C. nutans), commonly known as Sabah Snake Grass in southeast Asia, is widely used in folk medicine due to its analgesic, antiviral, and anti-inflammatory properties. Our recent study provided evidence for the regulation of cytosolic phospholipase A2 (cPLA2) mRNA expression by epigenetic fac...

journal_title：Neuromolecular medicine

authors： Tan CS,Ho CF,Heng SS,Wu JS,Tan BK,Ng YK,Sun GY,Lin TN,Ong WY

更新日期：2016-09-01 00:00:00

abstract：:Neuronal diseases, including retinal disorders, stroke, Alzheimer's disease, Parkinson's disease and spinal cord injury, affect a large number of people worldwide and cause heavy social and economic burdens. Although many efforts have been made by scientists and clinicians to develop novel drug and healthcare strategi...

journal_title：Neuromolecular medicine

authors： Xing X,Liu F,Xiao J,So KF

更新日期：2016-09-01 00:00:00

abstract：:Hereditary sensory and autonomic neuropathy 1 (HSAN1) is an autosomal dominant disorder that can be caused by variants in SPTLC1 or SPTLC2, encoding subunits of serine palmitoyl-CoA transferase. Disease variants alter the enzyme's substrate specificity and lead to accumulation of neurotoxic 1-deoxysphingolipids. We de...

journal_title：Neuromolecular medicine

authors： Suriyanarayanan S,Auranen M,Toppila J,Paetau A,Shcherbii M,Palin E,Wei Y,Lohioja T,Schlotter-Weigel B,Schön U,Abicht A,Rautenstrauss B,Tyynismaa H,Walter MC,Hornemann T,Ylikallio E

更新日期：2016-03-01 00:00:00

abstract：:The frequent co-occurrence of autism spectrum disorders (ASD) and epilepsy, or paroxysmal EEG abnormalities, defines a condition termed autism-epilepsy phenotype (AEP). This condition results, in some cases , from dysfunctions of glial inwardly rectifying potassium channels (Kir), which are mainly expressed in astrocy...

journal_title：Neuromolecular medicine

authors： Marchese M,Valvo G,Moro F,Sicca F,Santorelli FM

更新日期：2016-03-01 00:00:00

abstract：:In addition to myelin loss and oligodendrocyte injury, axonal damage is a major cause of irreversible neurological disability in multiple sclerosis (MS). A series of studies have demonstrated that Rho kinase (ROCK) is involved in synaptic plasticity of neurons. Here, we found that ROCK activity in MS serum was elevate...

journal_title：Neuromolecular medicine

authors： Chen C,Yu JZ,Zhang Q,Zhao YF,Liu CY,Li YH,Yang WF,Ma CG,Xiao BG

更新日期：2015-12-01 00:00:00

abstract：:A number of studies have investigated the association between tumor necrosis factor (TNF)-α gene polymorphisms and ischemic stroke susceptibility. However, results of different individual studies are often inconsistent. To provide a more robust evaluation of the association between polymorphisms of the TNF-α gene and ...

journal_title：Neuromolecular medicine

authors： Niu YM,Weng H,Zhang C,Yuan RX,Yan JZ,Meng XY,Luo J

更新日期：2015-12-01 00:00:00

abstract：:Neurons and especially their synapses often project long thin processes that can invaginate neighboring neuronal or glial cells. These "invaginating projections" can occur in almost any combination of postsynaptic, presynaptic, and glial processes. Invaginating projections provide a precise mechanism for one neuron to...

journal_title：Neuromolecular medicine

authors： Petralia RS,Wang YX,Mattson MP,Yao PJ

更新日期：2015-09-01 00:00:00

abstract：:We have previously reported that mild traumatic brain injury (mTBI) induced cognitive deficits as well as apoptotic changes in the brains of mice. Apoptosis may be caused by severe, prolonged accumulation of misfolded proteins, and protein aggregation in the endoplasmic reticulum (ER stress). In an additional study, w...

journal_title：Neuromolecular medicine

authors： Rubovitch V,Barak S,Rachmany L,Goldstein RB,Zilberstein Y,Pick CG

更新日期：2015-03-01 00:00:00

abstract：:Origins of onset and progression of motor neurodegeneration in amyotrophic lateral sclerosis (ALS) are not clearly known, but may include impairment of mitochondrial bioenergetics. We used quantitative PCR approaches to analyze the mitochondrial oxidative phosphorylation (OXPHOS) transcriptomes of spinal cord tissue a...

journal_title：Neuromolecular medicine

authors： Ladd AC,Keeney PM,Govind MM,Bennett JP Jr

更新日期：2014-12-01 00:00:00

abstract：:A methylation-based EWAS on carefully phenotyped individuals with Parkinson's disease (PD) was conducted to reveal prioritised genes and pathways with statistically significant and sizable changes in PD and in the anxiety that often accompanies it. This was followed by subsequent replication of top-ranked CpG sites. U...

journal_title：Neuromolecular medicine

authors： Moore K,McKnight AJ,Craig D,O'Neill F

更新日期：2014-12-01 00:00:00

abstract：:Hemorrhagic transformation (HT) of cerebral infarction is a common and serious occurrence following acute ischemic stroke. The expression of survivin, a member of the inhibitor of apoptosis protein family, has been shown to increase after cerebral ischemia. This protein has been mainly located at the microvasculature ...

journal_title：Neuromolecular medicine

authors： Mallolas J,Rodríguez R,Gubern C,Camós S,Serena J,Castellanos M

更新日期：2014-12-01 00:00:00

abstract：:Epidemiological studies demonstrate that pain frequently occurs comorbid with depression. Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cor...

journal_title：Neuromolecular medicine

authors： Liu SB,Zhao R,Li XS,Guo HJ,Tian Z,Zhang N,Gao GD,Zhao MG

更新日期：2014-06-01 00:00:00

abstract：:Despite the significant amount of experimental data available on trehalose, the molecular mechanism responsible for its intracellular stabilising properties has not emerged yet. The repair of cellular homeostasis in many protein-misfolding diseases by trehalose is credited to the disaccharide being an inducer of autop...

journal_title：Neuromolecular medicine

authors： Chaudhary RK,Kardani J,Singh K,Banerjee R,Roy I

更新日期：2014-06-01 00:00:00

abstract：:There is evidence that chronic hyponatremia, even when mild, may cause neurological signs and symptoms. These have been traditionally associated with water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts neg...

journal_title：Neuromolecular medicine

authors： Benvenuti S,Deledda C,Luciani P,Modi G,Bossio A,Giuliani C,Fibbi B,Peri A

更新日期：2013-09-01 00:00:00

abstract：:Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...

journal_title：Neuromolecular medicine

authors： Villar-Menéndez I,Blanch M,Tyebji S,Pereira-Veiga T,Albasanz JL,Martín M,Ferrer I,Pérez-Navarro E,Barrachina M

更新日期：2013-06-01 00:00:00