Abstract：
:Epileptic seizures have long been recognised as a complication of the clinical syndrome of Alzheimer's disease, particularly in advanced disease, but have hitherto been viewed essentially as epiphenomena of the neurodegenerative process. Progress with animal models of Alzheimer's disease has suggested that this view may be incorrect, and that seizures may be a reflection of pathophysiological processes similar to or overlapping with those responsible for cognitive decline. This overlap between neuropsychological and neurophysiological changes suggests that seizures in Alzheimer's disease may be a valid therapeutic target, over and above symptomatic treatment. This article reviews data on the prevalence of seizures in Alzheimer's disease, seizure types, pathophysiology and treatment. Seizure prevalence increases with disease duration, but early-onset disease is associated with a greater risk of seizures, in part related to the frequency of presenilin-1 gene mutations in early-onset disease. Seizures are mostly of partial origin, with both complex partial and secondary generalised seizures. Seizure pathophysiology may relate to increased amyloid beta-peptide production, structural alterations in neurones related to cytoskeletal dysfunction, cerebrovascular changes, neurotransmitter dysfunction or combinations thereof. Through modification of these pathophysiological pathways, there may be possible roles for anti-epileptic drugs such as sodium valproate and lacosamide in the treatment of Alzheimer's disease. In summary, epileptic seizures are part of the AD phenotype, and merit further investigation.
journal_name
Neuromolecular Medjournal_title
Neuromolecular medicineauthors
Larner AJdoi
10.1007/s12017-009-8076-zsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
71-7issue
1eissn
1535-1084issn
1559-1174journal_volume
12pub_type
杂志文章,评审abstract：:Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore prot...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/NMM:6:2-3:127
更新日期：2004-01-01 00:00:00
abstract：:P-glycoprotein (P-gp), which is coded by the MDR1 gene, in the brain capillary endothelial cell limits the entry of many drugs including antipsychotics into the brain. The aim of this study is to examine whether a functional polymorphism, a C to T substitution at position 3435 in exon 26 of the MDR1 gene, is associate...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-008-8041-2
更新日期：2008-01-01 00:00:00
abstract：:Danshensu (DSS) and tetramethylpyrazine (TMP) are active ingredients of Salvia miltiorrhiza Bge. and Ligusticum chuanxiong Hort that are widely used in oriental medicine. Structural combination of compounds with known biological activity may lead to the formation of a molecule with multiple properties or new function ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-016-8399-5
更新日期：2016-12-01 00:00:00
abstract：:The X-linked form of Charcot-Marie-Tooth disease (CMT1X) is the second most common molecularly designated form of hereditary motor and sensory neuropathy. The clinical phenotype is characterized by progressive distal muscle atrophy and weakness, areflexia, and variable sensory abnormalities. Affected males have modera...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/nmm:8:1-2:107
更新日期：2006-01-01 00:00:00
abstract：:Origins of onset and progression of motor neurodegeneration in amyotrophic lateral sclerosis (ALS) are not clearly known, but may include impairment of mitochondrial bioenergetics. We used quantitative PCR approaches to analyze the mitochondrial oxidative phosphorylation (OXPHOS) transcriptomes of spinal cord tissue a...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-014-8321-y
更新日期：2014-12-01 00:00:00
abstract：:Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism. Elevated plasma Hcy levels (> 15 µM) result in a condition called hyperhomocysteinemia (HHcy), which is an independent risk factor in the development of various neurodegenerative disorders. Reactive oxygen species (ROS) produced b...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-018-8505-y
更新日期：2018-12-01 00:00:00
abstract：:There is increasing evidence implicating apoptosis-mediated cell death in the pathogenesis of neurodegenerative diseases. One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm, activating caspase-9, leading to the subsequent activation of downstream executioner ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/NMM:1:3:183
更新日期：2002-01-01 00:00:00
abstract：:Clinacanthus nutans Lindau (C. nutans), commonly known as Sabah Snake Grass in southeast Asia, is widely used in folk medicine due to its analgesic, antiviral, and anti-inflammatory properties. Our recent study provided evidence for the regulation of cytosolic phospholipase A2 (cPLA2) mRNA expression by epigenetic fac...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-016-8404-z
更新日期：2016-09-01 00:00:00
abstract：:There is evidence that chronic hyponatremia, even when mild, may cause neurological signs and symptoms. These have been traditionally associated with water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts neg...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-013-8235-0
更新日期：2013-09-01 00:00:00
abstract：:The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the clinical and pathological picture of Alzheimer's Disease. An apparent symptom ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-009-8100-3
更新日期：2010-03-01 00:00:00
abstract：:Millions of individuals with active TB do not receive recommended treatments, and instead may use botanicals, or use botanicals concurrently with established treatments. Many botanicals protect against oxidative stress, but this can interfere with redox-dependent activation of isoniazid and other prodrugs used for pro...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8402-1
更新日期：2016-09-01 00:00:00
abstract：:Substantial evidence indicates bioenergetic dysfunction and mitochondrial impairment contribute either directly and/or indirectly to the pathogenesis of numerous neurodegenerative disorders. Treatment paradigms aimed at ameliorating this cellular energy deficit and/or improving mitochondrial function in these neurodeg...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-008-8053-y
更新日期：2008-01-01 00:00:00
abstract：:In addition to myelin loss and oligodendrocyte injury, axonal damage is a major cause of irreversible neurological disability in multiple sclerosis (MS). A series of studies have demonstrated that Rho kinase (ROCK) is involved in synaptic plasticity of neurons. Here, we found that ROCK activity in MS serum was elevate...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-015-8374-6
更新日期：2015-12-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08574-2
更新日期：2020-03-01 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-020-08635-x
更新日期：2021-01-03 00:00:00
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journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-020-08600-8
更新日期：2020-09-01 00:00:00
abstract：:Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD), and several pharmacological therapies have shown its implication in this neurodegenerative disorder. The main goal of this study was to gain insight ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-013-8219-0
更新日期：2013-06-01 00:00:00
abstract：:More than 30 genetic causes have been identified for the inherited neuropathies collectively referred to as Charcot-Marie-Tooth (CMT) disease. Previous therapies for CMT were limited to traditional approaches such as rehabilitation medicine, ambulation aids, and pain management. Identification of the genes causing CMT...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1385/nmm:8:1-2:255
更新日期：2006-01-01 00:00:00
abstract：:Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individuals of Ashkenazi Jewish descent. The pathological and clinical manifestations of ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-007-8019-5
更新日期：2008-01-01 00:00:00
abstract：:Hemorrhagic transformation (HT) of cerebral infarction is a common and serious occurrence following acute ischemic stroke. The expression of survivin, a member of the inhibitor of apoptosis protein family, has been shown to increase after cerebral ischemia. This protein has been mainly located at the microvasculature ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-014-8333-7
更新日期：2014-12-01 00:00:00
abstract：:Vitamin D deficiency is suggested to be associated with Parkinson's disease (PD). Our aim was to investigate the serum 25-hydroxyvitamin D3 (25OHD) levels of PD patients in Turkish cohort, to investigate any association of vitamin D binding protein (GC) genotypes with PD due to the significant role of GC in vitamin D ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-016-8415-9
更新日期：2017-03-01 00:00:00
abstract：:The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence in the general population is approximately 25%. Central fat accumulation and i...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-008-8022-5
更新日期：2008-01-01 00:00:00
abstract：:Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cy...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-012-8212-z
更新日期：2013-03-01 00:00:00
abstract：:The wide use of serotonin reuptake inhibitors and serotonin receptor agonists in anxiety disorders has suggested a key role for the modulatory neurotransmitter in anxiety. However, serotonin's specific role is still uncertain. This article reviews the literature concerning how and where serotonergic agents modulate an...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1385/NMM:5:1:027
更新日期：2004-01-01 00:00:00
abstract：:The cerebral ischemia is one of the most common diseases in the central nervous system that causes progressive disability or even death. In this connection, the inflammatory response mediated by the activated microglia is believed to play a central role in this pathogenesis. In the event of brain injury, activated mic...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8394-x
更新日期：2016-09-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy and related pathways have also been implicated in the etiology of ASD. We aimed to investigate autophagic markers by generating the transge...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08579-x
更新日期：2020-06-01 00:00:00
abstract：:A number of studies have investigated the association between tumor necrosis factor (TNF)-α gene polymorphisms and ischemic stroke susceptibility. However, results of different individual studies are often inconsistent. To provide a more robust evaluation of the association between polymorphisms of the TNF-α gene and ...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12017-015-8365-7
更新日期：2015-12-01 00:00:00
abstract：:He spent tens of thousands of hours peering through the oculars of a microscope at stained brain tissue sections from thousands of patients who died with or without a neurodegenerative disorder; most of those patients he had himself cared for and had removed and processed their brain tissues upon their death. His disc...
journal_title：Neuromolecular medicine
pub_type： 传,历史文章,杂志文章
doi：10.1007/s12017-010-8124-8
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Scutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in experimentally induced cerebral ischemia; however, the underlying mechanism for this has not been fully clarified. We sought to elucidate if scutellarin would exert its anti-i...
journal_title：Neuromolecular medicine
pub_type： 杂志文章
doi：10.1007/s12017-019-08582-2
更新日期：2020-06-01 00:00:00
abstract：:Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments...
journal_title：Neuromolecular medicine
pub_type： 杂志文章,评审
doi：10.1007/s12017-016-8403-0
更新日期：2016-09-01 00:00:00
